Activated Platelet-Homing Nanoplatform for Targeting Magnetic Resonance Imaging of Aneurysm-Related Thrombus in Rabbits

• Published in: ACS applied materials & interfaces Vol. 13; no. 43; pp. 50705 - 50715
• Main Authors: Zhang, Yang, Cheng, Sijie, He, Yu, Tang, Chaojie, Liu, Feng, Sun, Yun, Zhao, Shuo, Mok, Greta S. P, Yang, Hong, Zhou, Zhiguo, Wang, Wu
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.11.2021
• Subjects: Aneurysm - diagnostic imaging; Aneurysm - drug therapy; Animals; Biological and Medical Applications of Materials and Interfaces; Cell Survival - drug effects; Magnetic Resonance Imaging; Metal-Organic Frameworks - chemical synthesis; Metal-Organic Frameworks - chemistry; Metal-Organic Frameworks - pharmacology; Molecular Structure; Nanoparticles - chemistry; Platelet Activation - drug effects; Rabbits; Thrombosis - diagnostic imaging; Thrombosis - drug therapy; magnetic resonance imaging; thrombus; Zn(II)-bis(dipicolylamine); rabbits; aneurysms

Thrombosis is closely related to the instability of intracranial aneurysm (IA), whose rupture is associated with high morbidity and mortality. It is difficult to detect an IA-related thrombus because traditional magnetic resonance imaging (MRI) and even contrast-enhanced MRI cannot clearly distingui...