Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems and Implantable Liver Constructs

• Published in: ACS applied materials & interfaces Vol. 10; no. 1; pp. 114 - 126
• Main Authors: Damania, Apeksha, Kumar, Anupam, Teotia, Arun K, Kimura, Haruna, Kamihira, Masamichi, Ijima, Hiroyuki, Sarin, Shiv Kumar, Kumar, Ashok
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 10.01.2018
• Subjects: Cryogels; Extracellular Matrix; Hepatocytes; Humans; Liver; Liver, Artificial; Tissue Engineering; Tissue Scaffolds; implantable liver construct; liver failure; decellularized liver; bioartificial liver; regeneration; cryogel

Recent progress in the use of decellularized organ scaffolds as regenerative matrices for tissue engineering holds great promise in addressing the issue of donor organ shortage. Decellularization preserves the mechanical integrity, composition, and microvasculature critical for zonation of hepatocyt...