Hydrogel Mechanics Influence the Growth and Development of Embedded Brain Organoids

• Published in: ACS applied bio materials Vol. 5; no. 1; pp. 214 - 224
• Main Authors: Cassel de Camps, Camille, Aslani, Saba, Stylianesis, Nicholas, Nami, Harris, Mohamed, Nguyen-Vi, Durcan, Thomas M, Moraes, Christopher
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.01.2022
• Subjects: Brain; Growth and Development; Hydrogels - chemistry; Organoids; Tissue Engineering - methods; alginate; matrix stiffness; hydrogels; brain organoids; neural rosettes; Matrigel

Brain organoids are three-dimensional, tissue-engineered neural models derived from induced pluripotent stem cells that enable studies of neurodevelopmental and disease processes. Mechanical properties of the microenvironment are known to be critical parameters in tissue engineering, but the mechani...