Development of Responsive Chitosan–Genipin Hydrogels for the Treatment of Wounds

• Published in: ACS applied bio materials Vol. 2; no. 7; pp. 2879 - 2888
• Main Authors: Heimbuck, Abitha M, Priddy-Arrington, Tyler R, Padgett, Madison L, Llamas, Claire B, Barnett, Haley H, Bunnell, Bruce A, Caldorera-Moore, Mary E
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.07.2019
• Subjects: fibroblast cytocompatibility and attachment; chitosan; chronic wound healing; wound dressing; responsive hydrogels; genipin
• ISSN: 2576-6422; 2576-6422
• DOI: 10.1021/acsabm.9b00266

Chronic wounds are characterized by an increased bacterial presence, alkaline pH, and excessive wound drainage. Hydrogel biomaterials composed of the carbohydrate polymer chitosan are advantageous for wound healing applications because of their innate antimicrobial and hemostatic properties. Here, g...