Enantioselective Synthesis of Acenaphthene-Type Monohydrosilanes

• Published in: Organic letters Vol. 27; no. 14; pp. 3622 - 3630
• Main Authors: Mu, Delong, Zhu, Xinrui, Chen, Jiean
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 11.04.2025; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; enantioselective synthesis; enantioselectivity; heterocyclic compounds; insecticidal properties; materials science; Physical Sciences; Science & Technology; silicon; silylation; RHODIUM; SILICON; HYDROSILYLATION; BONDS; SULFUR; C-H SILYLATION; DESYMMETRIZATION

Acenaphthene and its analogues are privileged frameworks in medicinal chemistry and material science. However, the properties of silicon-substituted acenaphthene-type scaffolds are poorly understood. Here, we report a rhodium-catalyzed intramolecular C­(sp3)–H silylation for enantioselective synthes...