BRF110, an Orally Active Nurr1-RXRα-Selective Rexinoid, Enhances BDNF Expression without Elevating Triglycerides - Asvos, Xenophon; El Mubarak, Mohamed A.; Karampelas, Theodoros; Rampias, Theodoros; Tamvakopoulos, Constantin; Sivolapenko, Gregory B.; Papakyriakou, Athanasios; Topouzis, Stavros; Vassilatis, Demetrios K.; Fokas, Demosthenes (Journal of medicinal chemistry, 2025)
Keywords: Administration, Oral; Animals; Brain-Derived Neurotrophic Factor - metabolism; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacokinetics; Neuroprotective Agents - pharmacology; Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism; Pyrimidines - chemical synthesis; Pyrimidines - chemistry; Pyrimidines - pharmacokinetics; Pyrimidines - pharmacology; Retinoid X Receptor alpha - metabolism; Structure-Activity Relationship; Triglycerides - metabolism