Intrinsic Kinetics Resolution of an Enantioselective Transesterification Catalyzed with the Immobilized Enzyme Novozym435

• Published in: ACS Engineering Au Vol. 4; no. 6; pp. 545 - 561
• Main Authors: Chaussard, Nicolas, Nikitine, Clémence, Fongarland, Pascal
• Format: Journal Article
• Language: English
• Published: American Chemical Society 18.12.2024
• Subjects: Chemical and Process Engineering; Engineering Sciences; enantioselective enzymatic transesterification; orthogonal collocations; Michaelis–Menten kinetics; effectiveness factor; Novozym435; kinetic modeling

This work investigates the kinetics of the enantioselective transesterification of ethyl butyrate and (R)-2-pentanol in a solventless medium biocatalyzed by Novozym435, an immobilized Candida antarctica Lipase B. A reaction-diffusion reversible Ping-Pong bi-bi model was developed to represent the re...