Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area

• Published in: Inorganic chemistry Vol. 61; no. 37; pp. 14705 - 14717
• Main Authors: Spector, Daniil V., Erofeev, Alexander S., Gorelkin, Petr V., Vaneev, Alexander N., Akasov, Roman A., Ul’yanovskiy, Nikolay V., Nikitina, Vita N., Semkina, Alevtina S., Vlasova, Kseniya Yu, Soldatov, Mikhail A., Trigub, Alexander L., Skvortsov, Dmitry A., Finko, Alexander V., Zyk, Nikolay V., Sakharov, Dmitry A., Majouga, Alexander G., Beloglazkina, Elena K., Krasnovskaya, Olga O.
• Format: Journal Article
• Language: English
• Published: American Chemical Society 19.09.2022

We report herein a Pt­(IV) prodrug with metronidazole in axial positions Pt-Mnz. The nitroaromatic axial ligand was conjugated with a cisplatin scaffold to irreversibly reduce under hypoxic conditions, thereby retaining the Pt­(IV) prodrug in the area of hypoxia. X-ray near-edge adsorption spectrosc...