Molecular pharming : applications, challenges and emerging areas
A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections lo...
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| Main Authors | , |
|---|---|
| Format | eBook Book |
| Language | English |
| Published |
Hoboken, NJ
Wiley Blackwell
2018
John Wiley & Sons, Incorporated Wiley-Blackwell |
| Edition | 1 |
| Subjects | |
| Online Access | Get full text |
| ISBN | 9781118801284 1118801288 |
| DOI | 10.1002/9781118801512 |
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| Abstract | A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities. |
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| AbstractList | A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities. |
| Author | Kermode, Allison R. Jiang, Liwen |
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| Publisher | Wiley Blackwell John Wiley & Sons, Incorporated Wiley-Blackwell |
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| Snippet | A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the... |
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| SubjectTerms | Materia medica, Vegetable Molecular pharmacology Plant biotechnology |
| TableOfContents | 4.2 N-Glycan engineering -- 4.3 O-glycan engineering -- 4.4 Outlook: The emerging field of Genome Editing -- Acknowledgements -- References -- Part Three Plant Platforms, Subcellular Targeting, Recovery, and Downstream Processing -- Chapter 5 Seeds as Bioreactors -- Abbreviations -- 5.1 Introduction -- 5.2 Plant Bioreactor Systems -- 5.3 Seeds are Native Protein Bioreactors -- 5.4 Seed Protein Storage Vacuole as bioreactors -- 5.5 Seed Oil Bodies as bioreactors -- 5.6 Examples of seed-derived Recombinant Proteins -- 5.7 Considerations for the use of seeds as bioreactors: Factors and approaches -- 5.8 Conclusions and Future Prospects -- Acknowledgements -- References -- Chapter 6 Strategies to Increase Expression and Accumulation of Recombinant Proteins -- Abbreviations -- 6.1 Introduction -- 6.2 Strategies for enhancing the expression and accumulation of Recombinant Proteins -- 6.3 Summary and conclusions -- References -- Chapter 7 The Impact of Six Critical Impurities on Recombinant Protein Recovery and Purification from Plant Hosts -- Abbreviations -- 7.1 Introduction -- 7.2 Plant Expression Platforms and Implications on Downstream Processing -- 7.3 The 6Ps -- 7.4 Summary and Conclusion -- References -- Chapter 8 Plant Recombinant Lysosomal Enzymes as Replacement Therapeutics for Lysosomal Storage Diseases: Unique Processing for Lysosomal Delivery and Efficacy -- Abbreviations -- 8.1 Introduction -- 8.2 Human Lysosomal Storage Diseases and the Development of Enzyme Replacement Therapies -- 8.3 General Challenges Associated with Conventional mammalian‐cell‐based Production Platforms -- 8.4 Plant-based Production Systems - General Advantages and challenges for generating LSD Replacement Therapeutics -- 8.5 Biochemistry Underlying the Mammalian Cellular machinery for M6P elaboration in More Detail Chapter 13 Biosafety, Risk Assessment, and Regulation of Molecular Farming -- Abbreviations -- 13.1 Introduction -- 13.2 The need for a Regulatory System -- 13.3 International regulation of GM crops -- 13.4 Regulation of the Intended Use of the product -- 13.5 Molecular Farming Platforms - Key Regulatory Aspects -- 13.6 Molecular Farming Products - Key Regulatory Aspects -- 13.7 Case studies -- 13.8 Conclusions and Future Perspectives -- Acknowledgements -- References -- Part Six Emerging Areas: Plant Specialized Metabolites and Small Molecule Drugs -- Chapter 14 Harnessing Plant Trichome Biochemistry for the Production of Useful Compounds -- Abbreviations -- 14.1 Introduction -- 14.2 Diversity of Compounds Produced by Glandular Trichomes -- 14.3 Glandular Trichomes as a Source of Enzymes and Genes for Metabolic Engineering -- 14.4 Can Other Organisms Compete for the Production of Trichome‐Based Compounds? -- 14.5 Engineering Trichomes for the Production of Novel Compounds -- 14.6 Conclusions -- References -- Chapter 15 Reconstitution of Medicinally Important Plant Natural Products in Microorganisms -- Abbreviations -- 15.1 Introduction -- 15.2 Heterologous Production of Medicinally Important Plant Natural Products -- 15.3 Conclusions -- Acknowledgements -- References -- Chapter 16 Screening of Epidermal Growth Factor Receptor Inhibitors in Natural Products Derived From Extracts of Traditional Chinese Medicines -- Abbreviations -- 16.1 Introduction -- 16.2 Strategies for Screening Bioactive Compounds From Natural Product Resources -- 16.3 New Technologies Used for Natural Product Dereplication -- 16.4 Development of an EGFR Inhibition Assay Method with Capillary Electrophoresis -- 16.5 Screening of Natural Product Extracts and Identification of the Active Components -- 16.6 Conclusions -- Acknowledgments -- References Chapter 17 Target-Directed Evolution of Mutant Transgenic Plant Cells as a Novel Source of Drugs -- Abbreviations -- 17.1 Introduction -- 17.2 Development of the Technology - the Mutagenic Strategy -- 17.3 Development of the Technology‐Selection of Mutants -- 17.4 Target-Directed Evolution -- 17.5 Proof of Concept for Target‐Directed Evolution in Lobelia cardinalis -- 17.6 Generation and Selection of Transgenic (hDAT) Cell Cultures -- 17.7 Pharmacological Analysis of Culture Extracts -- 17.8 Development of Traditional Medicinal Plant Extracts -- 17.9 Chemical analysis of Culture Extracts for Lobinaline Content -- 17.10 Biosynthetic Production Systems -- 17.11 Other Metabolites with Inhibitory Activity on the DAT? -- 17.12 Chemical and Biosynthetic Compound Libraries -- 17.13 A Bonus! Neuroprotective Metabolites -- 17.14 Another Bonus! Cytoprotective Gene Targets -- 17.15 Using the Technology in Reverse -- 17.16 Conclusions -- References -- Chapter 18 Plant Thermotolerance Proteins, Misfolded Proteins, and Neurodegenerative Diseases -- Abbreviations -- 18.1 Introduction -- 18.2 Human Neurodegenerative Diseases -- 18.3 Conservation of the Plant and Human Genomes Provides a Tool to Further Understand Human Diseases -- 18.4 Numerous Neuronal Proteins are Conserved in Plants -- 18.5 Conservation of Kinases and Ubiquitin Ligase Functions -- 18.6 Thermotolerance and Proteases - the Clearance of Misfolded Proteins -- 18.7 Conservation of Oxidative Stress Related Proteins and the Link to Neurodegeneration -- 18.8 The Value of Plants in Understanding the Mechanisms of Non‐plant Proteins Associated with Neurodegeneration -- 18.9 Concluding Remarks and Future Directions -- References -- Index -- Supplemental Images -- EULA 8.6 Approaches to effect the M6P tagging of plant-Produced Recombinant Lysosomal Enzymes Under Development for ERT -- 8.7 Alternative strategies for Lysosomal Delivery and Improved Biodistribution of ERTs -- 8.8 Future directions -- Acknowledgements -- References -- Part Four Plant-Derived Protein Pharmaceuticals and Case Studies -- Chapter 9 Plant-Produced Antibodies and Post-Translational Modification -- Abbreviations -- 9.1 Introduction -- 9.2 IgGs and Post‐Translational Engineering -- 9.3 Production and Engineering of IgA and IgM mAbs -- 9.4 Conclusions -- Acknowledgements -- References -- Chapter 10 Molecular Pharming: Plant-Made Vaccines -- Abbreviations -- 10.1 Introduction -- 10.2 Overview of Mammalian Immune System and Vaccines -- 10.3 Plant Expression Systems -- 10.4 Plant-made vaccines -- 10.5 Prospects for future Development of plant-made Vaccines -- Acknowledgments -- References -- Chapter 11 Transgenic Rice for the Production of Recombinant Pharmaceutical Proteins: A Case Study of Human Serum Albumin -- Abbreviations -- 11.1 Introduction: Challenges of Generating Recombinant Human Serum Albumin -- 11.2 Strategies to overcome the challenges of Generating Recombinant HSA -- 11.3 Characterization of OsrHSA -- 11.4 Processing and manufacturing OsrHSA from Rice Grain -- 11.5 Safety assessment of OsrHSA -- 11.6 OsrHSA and pHSA Exhibit Similar Pharmacokinetic Features -- 11.7 OsrHSA Exhibits Similar Therapeutic Efficacy to pHSA -- 11.8 Conclusions and perspectives -- References -- Chapter 12 Enzymes for Industrial and Pharmaceutical Applications - From Individual to Population Level Impact -- Abbreviations -- 12.1 Introduction -- 12.2 Industrial enzymes -- 12.3 Pharmaceutical enzymes -- 12.4 Future directions -- Acknowledgements -- References -- Part Five Regulatory Issues Intro -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- Part One The Molecular Farming/Pharming Landscape -- Chapter 1 Current Status and Perspectives of the Molecular Farming Landscape -- Abbreviations -- 1.1 Introduction -- 1.2 Brief history of Molecular Farming -- 1.3 Recent developments in R& -- D and commercialization -- 1.4 Commercial products and platforms -- 1.5 Downstream processing and infrastructure -- 1.6 Plant matrix encapsulation as an alternative to purification -- 1.7 Perspectives and opportunities for the future -- 1.8 Conclusions -- Acknowledgements -- References -- Part Two Molecular Biology of Plant Expression Systems and Manipulation of Glycosylation Processes in Plants -- Chapter 2 Synthetic Transcription Activator-Like Effector-Activated Promoters for Coordinated Orthogonal Gene Expression in Plants: Applications for Regulatory Circuit and Metabolic Engineering -- Abbreviations -- 2.1 Introduction -- 2.2 Synthetic TALE-activated Promoters: Design, Construction, and Testing -- 2.3 Designing Regulatory Circuits -- 2.4 Modeling the networks -- 2.5 Input signals -- 2.6 Output -- 2.7 Conclusions -- References -- Chapter 3 Contemporary and Emerging Technologies for Precise N-glycan Analyses -- Abbreviations -- 3.1 Introduction -- 3.2 Common and Disparate Features During Biosynthesis -- 3.3 Basic Considerations for Glycomics -- 3.4 N-glycan release -- 3.5 N-glycan purification -- 3.6 N-glycan derivatization -- 3.7 N-glycan HPLC and CE -- 3.8 N-glycan Mass Spectrometry -- 3.9 Exoglycosidase and Chemical Digestion of glycans -- 3.10 N-glycan arrays -- 3.11 Glycomic databases -- 3.12 N-glycans from plants and algae -- 3.13 Conclusions -- References -- Chapter 4 Production of Functionally Active Recombinant Proteins in Plants: Manipulating N- and O-glycosylation -- Abbreviations -- 4.1 Introduction |
| Title | Molecular pharming : applications, challenges and emerging areas |
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