Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease

• Published in: JAMA neurology Vol. 70; no. 7; p. 903
• Main Authors: Doré, Vincent, Villemagne, Victor L, Bourgeat, Pierrick, Fripp, Jurgen, Acosta, Oscar, Chetélat, Gael, Zhou, Luping, Martins, Ralph, Ellis, Kathryn A, Masters, Colin L, Ames, David, Salvado, Oliver, Rowe, Christopher C
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Aged; Aged, 80 and over; Aging - metabolism; Aging - pathology; Aging - physiology; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - metabolism; Atrophy; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Male; Memory Disorders - metabolism; Memory Disorders - pathology; Memory Disorders - physiopathology; Memory, Episodic; Positron-Emission Tomography; Prodromal Symptoms

β-amyloid (Aβ) deposition is one of the hallmarks of Alzheimer disease. Aβ deposition accelerates gray matter atrophy at early stages of the disease even before objective cognitive impairment is manifested. Identification of at-risk individuals at the presymptomatic stage has become a major research...