Grafting from Small Interfering Ribonucleic Acid (siRNA) as an Alternative Synthesis Route to siRNA–Polymer Conjugates

• Published in: Macromolecules Vol. 48; no. 16; pp. 5640 - 5647
• Main Authors: Lin, En-Wei, Maynard, Heather D
• Format: Journal Article
• Language: English
• Published: American Chemical Society 25.08.2015
• Subjects: electron transfer; gel electrophoresis; mass spectrometry; molecular weight; nuclear magnetic resonance spectroscopy; polyethylene glycol; polymerization; small interfering RNA

Small interfering ribonucleic acids (siRNAs) are important therapeutic agents and are challenging to deliver efficiently. To address this, covalent attachment of synthetic polymers to siRNA has become of great interest. In this report, we present a synthetic route to siRNA–polymer conjugates by the...