Necrotizing fasciitis: report of 39 pediatric cases
Necrotizing fasciitis (NF) is a severe, life-threatening soft tissue infection. General features and risk factors for fatal outcome in children are not well known. To characterize the features of NF in children and the risk factors for fatal outcome. Retrospective, comparative, observational, and lo...
Saved in:
Published in | Archives of dermatology (1960) Vol. 138; no. 7; p. 893 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.07.2002
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Necrotizing fasciitis (NF) is a severe, life-threatening soft tissue infection. General features and risk factors for fatal outcome in children are not well known.
To characterize the features of NF in children and the risk factors for fatal outcome.
Retrospective, comparative, observational, and longitudinal trial.
Dermatology department of a tertiary care pediatric hospital.
All patients with clinical and/or histopathological diagnosis of NF seen from January 1, 1971, through December 31, 2000.
Incidence, age, sex, number and location of lesions, preexisting conditions, initiating factors, clinical and laboratory features, diagnosis at admission, treatment, evolution, sequelae, and risk factors for fatal outcome.
We examined 39 patients with NF (0.018% of all hospitalized patients). Twenty-one patients (54%) were boys. Mean age was 4.4 years. Single lesions were seen in 30 (77%) of patients, with 21(54%) in extremities. The most frequent preexisting condition was malnutrition in 14 patients (36%). The most frequent initiating factor was varicella in 13 patients (33%). Diagnosis of NF at admission was made in 11 patients (28%). Bacterial isolations in 24 patients (62%) were polymicrobial in 17 (71%). Pseudomonas aeruginosa was the most frequently isolated bacteria; gram-negative isolates, the most frequently associated bacteria. Complications were present in 33 patients (85%), mortality in 7 (18%), and sequelae in 29 (91%) of 32 surviving patients. The significant risk factor related to a fatal outcome was immunosuppression.
Necrotizing fasciitis in children is frequently misdiagnosed, and several features differ from those of NF in adults. Immunosuppression was the main factor related to death. Early surgical debridement and antibiotics were the most important therapeutic measures. |
---|---|
AbstractList | Necrotizing fasciitis (NF) is a severe, life-threatening soft tissue infection. General features and risk factors for fatal outcome in children are not well known.
To characterize the features of NF in children and the risk factors for fatal outcome.
Retrospective, comparative, observational, and longitudinal trial.
Dermatology department of a tertiary care pediatric hospital.
All patients with clinical and/or histopathological diagnosis of NF seen from January 1, 1971, through December 31, 2000.
Incidence, age, sex, number and location of lesions, preexisting conditions, initiating factors, clinical and laboratory features, diagnosis at admission, treatment, evolution, sequelae, and risk factors for fatal outcome.
We examined 39 patients with NF (0.018% of all hospitalized patients). Twenty-one patients (54%) were boys. Mean age was 4.4 years. Single lesions were seen in 30 (77%) of patients, with 21(54%) in extremities. The most frequent preexisting condition was malnutrition in 14 patients (36%). The most frequent initiating factor was varicella in 13 patients (33%). Diagnosis of NF at admission was made in 11 patients (28%). Bacterial isolations in 24 patients (62%) were polymicrobial in 17 (71%). Pseudomonas aeruginosa was the most frequently isolated bacteria; gram-negative isolates, the most frequently associated bacteria. Complications were present in 33 patients (85%), mortality in 7 (18%), and sequelae in 29 (91%) of 32 surviving patients. The significant risk factor related to a fatal outcome was immunosuppression.
Necrotizing fasciitis in children is frequently misdiagnosed, and several features differ from those of NF in adults. Immunosuppression was the main factor related to death. Early surgical debridement and antibiotics were the most important therapeutic measures. |
Author | Duran-Mckinster, Carola Fustes-Morales, Antonio Gutierrez-Castrellon, Pedro Tamayo-Sanchez, Lourdes Ruiz-Maldonado, Ramon Orozco-Covarrubias, Luz |
Author_xml | – sequence: 1 givenname: Antonio surname: Fustes-Morales fullname: Fustes-Morales, Antonio organization: Department of Pediatric Dermatology, National Institute of Pediatrics, Mexico City, Mexico – sequence: 2 givenname: Pedro surname: Gutierrez-Castrellon fullname: Gutierrez-Castrellon, Pedro – sequence: 3 givenname: Carola surname: Duran-Mckinster fullname: Duran-Mckinster, Carola – sequence: 4 givenname: Luz surname: Orozco-Covarrubias fullname: Orozco-Covarrubias, Luz – sequence: 5 givenname: Lourdes surname: Tamayo-Sanchez fullname: Tamayo-Sanchez, Lourdes – sequence: 6 givenname: Ramon surname: Ruiz-Maldonado fullname: Ruiz-Maldonado, Ramon |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12071816$$D View this record in MEDLINE/PubMed |
BookMark | eNo1jrtKBDEUQFOsuA_9AQvJD8yYe5OZ5NrJoquwaKNgtySZRCPOg2Qs9OsV1Oo0h8NZs8UwDoGxMxA1CAEXNvvXLuS-BmlqXRuSC7YSQsiKjH5esnUpbz8eGoPHbAkoNBhoV0zeB5_HOX2l4YVHW3xKcyqXPIdpzDMfI5fEp9AlO-fkubcllBN2FO17Cad_3LCnm-vH7W21f9jdba_2lZXYzJUGQYRRUhPQKtU4IVuSSjdNVAqACAIpUI4ixrYjAAfOOQLdtYhkWtyw89_u9OH60B2mnHqbPw__9_gNCatGCw |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1001/archderm.138.7.893 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
ExternalDocumentID | 12071816 |
Genre | Journal Article |
GroupedDBID | --- -QF .55 .GJ .XZ 1CY 23M 2CT 2WC 354 39C 3O- 4.4 41~ 53G 5GY 6J9 AAWTL AAYEP ABCQX ABJNI ABOCM ACGFO ACGFS ADBBV AFFNX AI. ALMA_UNASSIGNED_HOLDINGS AMJDE ARBJA BAWUL BCGUY BRYMA C1A C45 CGR CS3 CUY CVF E3Z EAM EBS ECM EIF EJD EMOBN EX3 F3I F5P IH2 J5H L7B MJL N4W N9A NPM OB3 OBH OGROG OHH OVD P2P RAJ SJN SV3 TEORI TR2 VH1 VVN WH7 WOW X7M XHN YOC ZGI ZXP ZY1 |
ID | FETCH-LOGICAL-a325t-710992f395e2a445b036934755f4411991e9414b9f2f6d911b1bbb917d6229862 |
ISSN | 0003-987X |
IngestDate | Sat Sep 28 08:40:03 EDT 2024 |
IsPeerReviewed | false |
IsScholarly | false |
Issue | 7 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-a325t-710992f395e2a445b036934755f4411991e9414b9f2f6d911b1bbb917d6229862 |
PMID | 12071816 |
ParticipantIDs | pubmed_primary_12071816 |
PublicationCentury | 2000 |
PublicationDate | 2002-07-01 |
PublicationDateYYYYMMDD | 2002-07-01 |
PublicationDate_xml | – month: 07 year: 2002 text: 2002-07-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Archives of dermatology (1960) |
PublicationTitleAlternate | Arch Dermatol |
PublicationYear | 2002 |
SSID | ssj0012882 |
Score | 1.741973 |
Snippet | Necrotizing fasciitis (NF) is a severe, life-threatening soft tissue infection. General features and risk factors for fatal outcome in children are not well... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 893 |
SubjectTerms | Age Factors Bacterial Infections - diagnosis Bacterial Infections - etiology Bacterial Infections - mortality Bacteriological Techniques Cause of Death Child Child, Preschool Cross-Sectional Studies Fasciitis, Necrotizing - diagnosis Fasciitis, Necrotizing - etiology Fasciitis, Necrotizing - mortality Female Humans Incidence Infant Infant, Newborn Male Pseudomonas aeruginosa - pathogenicity Risk Factors Sex Factors Survival Rate |
Title | Necrotizing fasciitis: report of 39 pediatric cases |
URI | https://www.ncbi.nlm.nih.gov/pubmed/12071816 |
Volume | 138 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NTtwwELaWVqq4VLS0tAWqHHpDXim2k9i9oS0IVey2B5D2hmzHkZBgswpJD3kInpmZOMmGBSrgYkWxZcWeyfzY38wQ8sPFoIUT6aiIhaZCcEtNGFlqZaS1lQ6UFDqK01l8ci5-z6P5aHQ7QC1VpRnb-tG4ktdQFd4BXTFK9gWU7SeFF_AM9IUWKAzts2g8A5svLy_rBg2pQZlhgiL08f1NABqCXB0su2ocBxZU1s3QHB3mnU1RRpc-JRNmbwKnY3BMcFwBO9zQKQb0e8lyiNWHPYqrAfDAOl1RuJpONAagdPf5f11a9IN-VaAa6dQiMKfsQhCL_KrXDX-KvLY5neT_dFFU5tKHm51W9b3TiRWSdSVxOVUymd-TuFwOWCsZyE_pyyU-kOu-nkADnIXNGMME42S8Nhi2d3ndUDpkYDhJH8P5_961XNtd1wbZSCTKyxme_bR3UkxK1tVfxBW1IViYw-rhh2Ey2nayNYelMVzOtsj71uMIDj37fCAjt_hI3k1bTMU24QMuCnou-hl4HgryLOAq6HkoaHjoEzk_PjqbnNC2lAbVnEVlg7hVLOMqckwLERkwXBQXSRRlYA8j_M0pEQqjMpbFKShAExpjwJVPY8YUeL2fyZtFvnBfSGAdiPFMCmUTJ1SstRM2TBMhTZpqadRXsuOXe7H0-VIuuo349mTPLtlcMc8eeZvBD-r2wdorzfeGCHdrs1F0 |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Necrotizing+fasciitis%3A+report+of+39+pediatric+cases&rft.jtitle=Archives+of+dermatology+%281960%29&rft.au=Fustes-Morales%2C+Antonio&rft.au=Gutierrez-Castrellon%2C+Pedro&rft.au=Duran-Mckinster%2C+Carola&rft.au=Orozco-Covarrubias%2C+Luz&rft.date=2002-07-01&rft.issn=0003-987X&rft.volume=138&rft.issue=7&rft.spage=893&rft_id=info:doi/10.1001%2Farchderm.138.7.893&rft_id=info%3Apmid%2F12071816&rft_id=info%3Apmid%2F12071816&rft.externalDocID=12071816 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-987X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-987X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-987X&client=summon |