Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor - McKinzie, David L; Winneroski, Leonard L; Green, Steven J; Hembre, Erik J; Erickson, Jon A; Willis, Brian A; Monk, Scott A; Aluise, Christopher D; Baker, Thomas K; Lopez, Jose E; Hendle, Jörg; Beck, James P; et al. (Journal of medicinal chemistry, 2021)
Keywords: Chemistry, Medicinal; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; BETA-SECRETASE; IN-VITRO; ALZHEIMERS-DISEASE; MUTATION; LYSOSOMAL STORAGE; OPTIMIZATION; MICE; AMYLOID PRECURSOR PROTEIN; CLEAVAGE; CATHEPSIN-D DEFICIENCY