Ferroptosis, Pyroptosis, and Cuproptosis in Alzheimer’s Disease

Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder characterized by progressive cognitive dysfunction. Epidemiological investigation has demonstrated that, after cardiovascular and cerebrovascular diseases, tumors, and other causes, AD has become a major heal...

Full description

Saved in:
Bibliographic Details
Published inACS chemical neuroscience Vol. 14; no. 19; pp. 3564 - 3587
Main Authors Wang, Qi, Sun, Jingyi, Chen, Tian, Song, Siyu, Hou, Yajun, Feng, Lina, Fan, Cundong, Li, Mingquan
Format Journal Article
LanguageEnglish
Published American Chemical Society 04.10.2023
Subjects
regulated cell death (RCD)
pyroptosis
ferroptosis
Alzheimer’s disease
cuproptosis
mechanism
Online AccessGet full text

Cover

Abstract Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder characterized by progressive cognitive dysfunction. Epidemiological investigation has demonstrated that, after cardiovascular and cerebrovascular diseases, tumors, and other causes, AD has become a major health issue affecting elderly individuals, with its mortality rate acutely increasing each year. Regulatory cell death is the active and orderly death of genetically determined cells, which is ubiquitous in the development of living organisms and is crucial to the regulation of life homeostasis. With extensive research on regulatory cell death in AD, increasing evidence has revealed that ferroptosis, pyroptosis, and cuproptosis are closely related to the occurrence, development, and prognosis of AD. This paper will review the molecular mechanisms of ferroptosis, pyroptosis, and cuproptosis and their regulatory roles in AD to explore potential therapeutic targets for the treatment of AD.
AbstractList Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder characterized by progressive cognitive dysfunction. Epidemiological investigation has demonstrated that, after cardiovascular and cerebrovascular diseases, tumors, and other causes, AD has become a major health issue affecting elderly individuals, with its mortality rate acutely increasing each year. Regulatory cell death is the active and orderly death of genetically determined cells, which is ubiquitous in the development of living organisms and is crucial to the regulation of life homeostasis. With extensive research on regulatory cell death in AD, increasing evidence has revealed that ferroptosis, pyroptosis, and cuproptosis are closely related to the occurrence, development, and prognosis of AD. This paper will review the molecular mechanisms of ferroptosis, pyroptosis, and cuproptosis and their regulatory roles in AD to explore potential therapeutic targets for the treatment of AD.
Author Li, Mingquan
Sun, Jingyi
Song, Siyu
Hou, Yajun
Wang, Qi
Feng, Lina
Chen, Tian
Fan, Cundong
AuthorAffiliation College of Integrated Chinese and Western Medicine
The Third Affiliated Clinical Hospital of the Changchun University of Chinese Medicine
The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences
Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Ministry of Education, Northeast Asia Research Institute of Traditional Chinese Medicine
Department of Neurology
AuthorAffiliation_xml – name: Department of Neurology
– name: The Third Affiliated Clinical Hospital of the Changchun University of Chinese Medicine
– name: The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences
– name: College of Integrated Chinese and Western Medicine
– name: Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Ministry of Education, Northeast Asia Research Institute of Traditional Chinese Medicine
Author_xml – sequence: 1
  givenname: Qi
  surname: Wang
  fullname: Wang, Qi
  organization: College of Integrated Chinese and Western Medicine
– sequence: 2
  givenname: Jingyi
  surname: Sun
  fullname: Sun, Jingyi
  organization: The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences
– sequence: 3
  givenname: Tian
  surname: Chen
  fullname: Chen, Tian
  organization: Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Ministry of Education, Northeast Asia Research Institute of Traditional Chinese Medicine
– sequence: 4
  givenname: Siyu
  surname: Song
  fullname: Song, Siyu
  organization: Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Ministry of Education, Northeast Asia Research Institute of Traditional Chinese Medicine
– sequence: 5
  givenname: Yajun
  surname: Hou
  fullname: Hou, Yajun
  organization: The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences
– sequence: 6
  givenname: Lina
  surname: Feng
  fullname: Feng, Lina
  email: fenglina0001@163.com
  organization: The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences
– sequence: 7
  givenname: Cundong
  orcidid: 0000-0003-4485-1344
  surname: Fan
  fullname: Fan, Cundong
  email: cdfan@sdfmu.edu.cn
  organization: The Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences
– sequence: 8
  givenname: Mingquan
  surname: Li
  fullname: Li, Mingquan
  email: Limingquan0001@126.com
  organization: The Third Affiliated Clinical Hospital of the Changchun University of Chinese Medicine
BookMark eNp9kLFOwzAQhi1UJNrCGzBkZCDFjp3EHqtCAakSDDBbjnNWUyVO8TVDmXgNXo8nIShFdGK6X3f_f7r7JmTkWw-EXDI6YzRhN8aiXUPjoQvtjFtKueAnZMyUkHHOFB8d6TMyQdxQmikqszGZLyGEdrtrscLr6Hn_p40vo0W3_W1ElY_m9fsaqgbC18cnRrcVgkE4J6fO1AgXhzolr8u7l8VDvHq6f1zMV7HhSbqLWeIKmnJqMs5yVjpXZLJIclU6ZViRc3CWK8sdFKXIUjBcgnJlIXLphLOQ8ym5Gvb2J711gDvdVGihro2HtkOdyExIpVJBe6sYrDa0iAGc3oaqMWGvGdU_xPQxMX0g1sfoEOunetN2wff__B_5Btg2d10
CitedBy_id crossref_primary_10_2147_ITT_S455881
crossref_primary_10_1002_adhm_202400652
crossref_primary_10_1038_s41467_023_44465_8
crossref_primary_10_3389_fcell_2023_1307501
crossref_primary_10_1007_s11596_024_2841_y
crossref_primary_10_1016_j_bioorg_2024_107260
Cites_doi 10.1039/C7MT00075H
10.1016/S0891-5849(02)01197-8
10.3760/cma.j.cn421213-20210717-01214
10.1007/s13311-014-0312-z
10.1073/pnas.1603244113
10.1016/S0140-6736(10)61349-9
10.1016/j.cell.2005.02.008
10.3233/JAD-180317
10.1021/acschembio.5b00245
10.1016/j.expneurol.2007.01.003
10.1038/s41422-020-00441-1
10.1523/JNEUROSCI.5543-03.2004
10.1038/s41586-019-1769-z
10.1038/cdd.2011.96
10.1172/JCI90519
10.1093/brain/awx059
10.1038/ncomms7760
10.1111/imr.12295
10.1016/j.coi.2007.09.002
10.1016/j.neulet.2013.04.057
10.1100/2012/756357
10.1016/S0944-7113(97)80021-9
10.1055/s-0028-1109504
10.12114/j.issn.1007-9572.2021.02.031
10.1016/j.jtemb.2014.06.018
10.1111/j.1471-4159.2010.06888.x
10.1186/1742-2094-9-199
10.1002/glia.20467
10.1038/nrneurol.2010.180
10.3389/fneur.2019.00074
10.1155/2020/1675613
10.3390/ijms23095056
10.1016/S1474-4422(14)70117-6
10.1189/jlb.0607402
10.3969/j.issn.1002-0152.2018.12.005
10.1016/S0140-6736(05)67889-0
10.1016/j.cellsig.2020.109633
10.1038/s41582-019-0158-4
10.1016/j.neulet.2012.04.030
10.1074/jbc.R118.003999
10.1186/1742-2094-5-38
10.1016/j.jneuroim.2008.09.012
10.1016/j.cell.2019.04.024
10.3233/JAD-190711
10.1016/j.cub.2011.09.040
10.1093/toxsci/kfw081
10.1155/2013/623241
10.1124/mol.108.046771
10.1016/j.bbagen.2012.11.020
10.1016/j.jtemb.2016.02.006
10.1016/j.cell.2011.10.033
10.1136/jnnp-2012-302883
10.1016/j.tibs.2016.09.002
10.4049/jimmunol.1100620
10.1021/acs.accounts.9b00248
10.1007/s00401-013-1177-7
10.1007/978-3-319-60189-2_10
10.1080/15548627.2020.1810918
10.3389/fcell.2021.653815
10.1038/s41419-020-2298-2
10.1196/annals.1306.012
10.1111/jcpe.13258
10.1126/science.abf0529
10.1016/S0966-842X(00)01936-3
10.1080/15548627.2023.2165323
10.1038/nature18590
10.1001/jama.2009.1913
10.1002/glia.22686
10.1016/S0140-6736(20)32205-4
10.1016/j.bbamcr.2020.118867
10.1371/journal.pone.0031302
10.1038/s41568-022-00459-0
10.1038/onc.2017.11
10.1038/s41467-017-02682-y
10.1016/j.jalz.2010.11.007
10.1038/nature24016
10.1186/2051-5960-2-63
10.1016/j.cell.2015.12.056
10.3233/JAD-2012-121222
10.1002/anie.202108961
10.3389/fncel.2020.00231
10.1016/j.cmet.2020.10.011
10.1016/j.jinorgbio.2016.10.009
10.1038/mp.2017.146
10.3760/cma.j.issn.1671-8925.2017.11.021
10.3233/JAD-132477
10.1038/s41467-021-22301-1
10.1038/nri3452
10.1046/j.1471-4159.2002.t01-1-01061.x
10.1016/j.jtemb.2014.05.003
10.1021/bi0620961
10.1038/srep35514
10.1007/s00775-009-0600-y
10.1016/j.chembiol.2020.03.012
10.1016/j.neuron.2021.01.005
10.1016/j.neurobiolaging.2007.06.006
10.1016/j.biopha.2019.109595
10.1016/j.peptides.2007.08.022
10.7150/thno.59776
10.1007/s12031-016-0839-z
10.16476/j.pibb.2019.0057
10.3760/cma.j.issn.0254-9026.2021.04.004
10.1016/j.tox.2011.03.001
10.1016/j.brainres.2014.08.040
10.1016/j.redox.2017.11.001
10.1038/s41590-021-00886-5
10.1016/bs.pmbts.2016.12.016
10.2174/1389450043345272
10.1038/s41392-020-0145-7
10.1016/j.cell.2013.12.010
10.1523/JNEUROSCI.3238-09.2009
10.1038/s41568-021-00417-2
10.1016/j.cell.2012.03.042
10.3760/cma.j.issn.0254-9026.2021.03.001
10.1016/j.biopsych.2013.04.011
10.1016/S1474-4422(16)00062-4
10.3233/JAD-170543
10.1038/s41380-022-01568-w
10.1038/s41598-020-64521-3
10.1007/s13311-019-00755-y
10.1038/nature15632
10.1016/j.freeradbiomed.2018.09.033
10.3233/JAD-179944
10.1016/j.jalz.2012.11.006
10.1016/j.mam.2005.07.010
10.1186/s12974-020-01976-1
10.1016/j.atherosclerosis.2022.03.005
10.1002/bip.20335
10.1016/j.cell.2017.11.048
10.1001/jama.2010.1553
10.3390/foods10040869
10.1007/s12035-014-9070-5
10.1016/S1535-6108(03)00050-3
10.3760/cma.j.cn113694-20211004-00679
10.1016/S1097-2765(02)00599-3
10.3390/medsci6020045
10.3389/fphys.2019.00139
10.1016/j.nut.2006.10.006
10.3760/cma.j.issn.0376-2491.2018.13.004
10.1073/pnas.1302212110
10.3233/JAD-180514
10.1001/jamaneurol.2016.4406
10.1038/embor.2013.15
10.1146/annurev-immunol-032712-095944
10.1016/j.jalz.2012.11.007
10.2174/156720511794604543
10.1007/s10534-018-0126-2
10.1038/nature18629
10.1038/s41392-020-00428-9
10.1016/j.bbi.2016.12.014
10.1016/j.tiv.2007.07.011
10.1016/j.neulet.2009.12.035
10.1038/358167a0
10.1016/j.jtemb.2012.04.012
10.1128/MCB.24.2.865-874.2004
10.1038/nature11729
10.1016/j.pneurobio.2020.101904
10.14348/molcells.2014.0104
10.1046/j.1471-4159.2000.0741749.x
10.1016/j.jalz.2007.04.381
10.1016/j.peptides.2005.09.002
10.1111/joim.12959
10.1186/s13045-020-00946-7
10.1074/jbc.R117.000176
10.1016/j.cell.2020.10.029
10.1007/s00401-012-0987-3
10.3389/fimmu.2021.770744
10.1038/ni.1636
10.1016/j.jchemneu.2005.07.003
10.1056/NEJMoa2212948
10.1038/s41589-019-0462-8
10.1016/j.freeradbiomed.2013.01.026
10.1186/s13195-016-0188-8
10.12114/j.issn.1007-9572.2021.00.121
10.3389/fnins.2019.01443
10.1186/s40035-022-00313-1
10.1038/nature06616
10.55782/ane-2015-2044
10.1016/j.arr.2020.101192
10.1038/s41580-020-0270-8
10.4049/jimmunol.0901363
10.1016/j.bbalip.2013.10.018
10.1016/j.cell.2013.03.030
10.1586/ern.11.170
10.1038/s41392-020-0180-4
10.1016/j.redox.2013.07.004
10.1523/JNEUROSCI.5245-10.2011
10.1093/cercor/bhx045
10.1038/cdd.2015.158
10.3760/cma.j.issn.1673-4394.2022.06.015
10.1038/nchembio.2239
10.1107/S1744309107041139
10.1097/WCO.0000000000000911
10.3233/JAD-143108
10.1038/npp.2013.208
10.1155/2018/2850341
10.1002/eji.200940185
10.1038/ncomms3909
10.1038/nri3705
10.1016/j.bbrc.2007.04.191
10.1016/j.redox.2017.01.021
10.1093/ajcn/63.5.797
10.3389/fnbeh.2020.00152
10.1073/pnas.0712245105
10.3389/fphys.2013.00111
10.15252/emmm.201606210
10.1074/jbc.M111.237974
10.1038/cddis.2016.208
10.1016/S1474-4422(14)70017-1
10.15252/embj.2018101064
10.1038/s41418-017-0012-4
ContentType Journal Article
Copyright 2023 American Chemical Society
Copyright_xml – notice: 2023 American Chemical Society
DBID AAYXX
CITATION
7X8
DOI 10.1021/acschemneuro.3c00343
DatabaseName CrossRef
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1948-7193
EndPage 3587
ExternalDocumentID 10_1021_acschemneuro_3c00343
d172261308
GroupedDBID ---
53G
55A
5VS
6J9
7~N
AABXI
AAKDD
ABFRP
ABMVS
ABQRX
ABUCX
ACGFO
ACGFS
ACS
ADBBV
ADHLV
AEESW
AENEX
AFEFF
AHGAQ
ALMA_UNASSIGNED_HOLDINGS
AQSVZ
BAWUL
EBS
ED~
F5P
GGK
GNL
GX1
IH9
JG~
OK1
RNS
ROL
RPM
UI2
VF5
VG9
W1F
AAYXX
ABJNI
BAANH
CITATION
CUPRZ
7X8
ID FETCH-LOGICAL-a325t-12fb0530a63171dffb68b279df9a1b73efc39c3febd465ea38e9fdb478f4fce73
IEDL.DBID ACS
ISSN 1948-7193
IngestDate Fri Aug 16 03:52:24 EDT 2024
Fri Aug 23 03:15:11 EDT 2024
Thu Oct 05 03:32:58 EDT 2023
IsPeerReviewed true
IsScholarly true
Issue 19
Keywords regulated cell death (RCD)
pyroptosis
ferroptosis
Alzheimer’s disease
cuproptosis
mechanism
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a325t-12fb0530a63171dffb68b279df9a1b73efc39c3febd465ea38e9fdb478f4fce73
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0003-4485-1344
PQID 2864899540
PQPubID 23479
PageCount 24
ParticipantIDs proquest_miscellaneous_2864899540
crossref_primary_10_1021_acschemneuro_3c00343
acs_journals_10_1021_acschemneuro_3c00343
PublicationCentury 2000
PublicationDate 2023-10-04
PublicationDateYYYYMMDD 2023-10-04
PublicationDate_xml – month: 10
  year: 2023
  text: 2023-10-04
  day: 04
PublicationDecade 2020
PublicationTitle ACS chemical neuroscience
PublicationTitleAlternate ACS Chem. Neurosci
PublicationYear 2023
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References ref99/cit99
ref3/cit3
ref81/cit81
ref16/cit16
ref185/cit185
ref23/cit23
ref115/cit115
ref187/cit187
ref181/cit181
ref111/cit111
ref113/cit113
ref183/cit183
ref117/cit117
ref48/cit48
ref74/cit74
ref189/cit189
ref119/cit119
ref10/cit10
ref35/cit35
ref93/cit93
ref42/cit42
ref120/cit120
ref178/cit178
ref122/cit122
ref61/cit61
ref176/cit176
ref67/cit67
ref128/cit128
ref124/cit124
ref126/cit126
ref54/cit54
ref137/cit137
ref11/cit11
ref102/cit102
ref29/cit29
ref174/cit174
Kwiatek-Majkusiak J. (ref105/cit105) 2015; 75
ref86/cit86
ref170/cit170
ref5/cit5
ref43/cit43
ref80/cit80
ref133/cit133
ref207/cit207
ref28/cit28
ref203/cit203
ref148/cit148
ref55/cit55
ref144/cit144
ref167/cit167
ref163/cit163
ref66/cit66
ref22/cit22
ref87/cit87
ref106/cit106
ref190/cit190
ref140/cit140
ref198/cit198
ref214/cit214
ref194/cit194
ref98/cit98
ref210/cit210
ref153/cit153
ref150/cit150
ref63/cit63
ref56/cit56
ref155/cit155
ref156/cit156
ref158/cit158
ref8/cit8
ref59/cit59
ref85/cit85
ref34/cit34
ref37/cit37
ref60/cit60
ref17/cit17
ref82/cit82
ref147/cit147
ref145/cit145
ref21/cit21
ref166/cit166
ref164/cit164
ref213/cit213
ref78/cit78
ref211/cit211
ref36/cit36
ref83/cit83
ref79/cit79
ref139/cit139
ref172/cit172
ref200/cit200
ref14/cit14
ref57/cit57
ref169/cit169
ref134/cit134
ref208/cit208
ref40/cit40
ref131/cit131
ref205/cit205
ref161/cit161
ref142/cit142
ref15/cit15
ref180/cit180
ref62/cit62
ref41/cit41
ref58/cit58
ref104/cit104
ref177/cit177
ref84/cit84
ref1/cit1
ref123/cit123
ref196/cit196
ref7/cit7
ref45/cit45
ref52/cit52
ref184/cit184
ref114/cit114
ref186/cit186
ref116/cit116
ref110/cit110
ref182/cit182
ref2/cit2
ref112/cit112
ref77/cit77
ref71/cit71
ref188/cit188
ref20/cit20
ref118/cit118
ref89/cit89
ref19/cit19
ref96/cit96
ref107/cit107
ref191/cit191
ref109/cit109
ref13/cit13
ref193/cit193
ref197/cit197
ref38/cit38
ref199/cit199
ref90/cit90
ref195/cit195
ref64/cit64
ref6/cit6
ref18/cit18
ref136/cit136
ref65/cit65
ref171/cit171
ref97/cit97
ref101/cit101
ref76/cit76
ref32/cit32
ref39/cit39
ref202/cit202
ref168/cit168
ref206/cit206
ref132/cit132
ref91/cit91
ref12/cit12
ref179/cit179
ref121/cit121
ref175/cit175
ref33/cit33
ref129/cit129
ref44/cit44
ref70/cit70
ref125/cit125
ref9/cit9
ref152/cit152
ref154/cit154
ref27/cit27
ref151/cit151
ref159/cit159
ref92/cit92
ref157/cit157
ref31/cit31
ref88/cit88
ref160/cit160
ref143/cit143
ref53/cit53
ref149/cit149
ref162/cit162
ref46/cit46
ref49/cit49
ref75/cit75
ref24/cit24
ref141/cit141
ref50/cit50
ref209/cit209
ref138/cit138
ref100/cit100
ref25/cit25
ref173/cit173
ref103/cit103
ref72/cit72
ref201/cit201
ref51/cit51
ref135/cit135
ref68/cit68
ref94/cit94
ref130/cit130
ref204/cit204
ref146/cit146
ref26/cit26
ref73/cit73
ref69/cit69
ref165/cit165
ref95/cit95
ref108/cit108
ref192/cit192
ref4/cit4
ref30/cit30
ref212/cit212
ref47/cit47
ref127/cit127
References_xml – ident: ref69/cit69
  doi: 10.1039/C7MT00075H
– ident: ref100/cit100
  doi: 10.1016/S0891-5849(02)01197-8
– ident: ref79/cit79
  doi: 10.3760/cma.j.cn421213-20210717-01214
– ident: ref52/cit52
  doi: 10.1007/s13311-014-0312-z
– ident: ref93/cit93
  doi: 10.1073/pnas.1603244113
– ident: ref10/cit10
  doi: 10.1016/S0140-6736(10)61349-9
– ident: ref16/cit16
  doi: 10.1016/j.cell.2005.02.008
– ident: ref104/cit104
  doi: 10.3233/JAD-180317
– ident: ref91/cit91
  doi: 10.1021/acschembio.5b00245
– ident: ref192/cit192
  doi: 10.1016/j.expneurol.2007.01.003
– ident: ref80/cit80
  doi: 10.1038/s41422-020-00441-1
– ident: ref135/cit135
  doi: 10.1523/JNEUROSCI.5543-03.2004
– ident: ref190/cit190
  doi: 10.1038/s41586-019-1769-z
– ident: ref161/cit161
  doi: 10.1038/cdd.2011.96
– ident: ref87/cit87
  doi: 10.1172/JCI90519
– ident: ref26/cit26
  doi: 10.1093/brain/awx059
– ident: ref151/cit151
  doi: 10.1038/ncomms7760
– ident: ref184/cit184
  doi: 10.1111/imr.12295
– ident: ref162/cit162
  doi: 10.1016/j.coi.2007.09.002
– ident: ref48/cit48
  doi: 10.1016/j.neulet.2013.04.057
– ident: ref179/cit179
  doi: 10.1100/2012/756357
– ident: ref21/cit21
  doi: 10.1016/S0944-7113(97)80021-9
– ident: ref22/cit22
  doi: 10.1055/s-0028-1109504
– ident: ref114/cit114
  doi: 10.12114/j.issn.1007-9572.2021.02.031
– ident: ref44/cit44
  doi: 10.1016/j.jtemb.2014.06.018
– ident: ref46/cit46
  doi: 10.1111/j.1471-4159.2010.06888.x
– ident: ref208/cit208
  doi: 10.1186/1742-2094-9-199
– ident: ref194/cit194
  doi: 10.1002/glia.20467
– ident: ref38/cit38
  doi: 10.1038/nrneurol.2010.180
– ident: ref103/cit103
  doi: 10.3389/fneur.2019.00074
– ident: ref110/cit110
  doi: 10.1155/2020/1675613
– ident: ref188/cit188
  doi: 10.3390/ijms23095056
– ident: ref123/cit123
  doi: 10.1016/S1474-4422(14)70117-6
– ident: ref168/cit168
  doi: 10.1189/jlb.0607402
– ident: ref111/cit111
  doi: 10.3969/j.issn.1002-0152.2018.12.005
– ident: ref7/cit7
  doi: 10.1016/S0140-6736(05)67889-0
– ident: ref88/cit88
  doi: 10.1016/j.cellsig.2020.109633
– ident: ref15/cit15
  doi: 10.1038/s41582-019-0158-4
– ident: ref42/cit42
  doi: 10.1016/j.neulet.2012.04.030
– ident: ref118/cit118
  doi: 10.1074/jbc.R118.003999
– ident: ref195/cit195
  doi: 10.1186/1742-2094-5-38
– ident: ref207/cit207
  doi: 10.1016/j.jneuroim.2008.09.012
– ident: ref3/cit3
  doi: 10.1016/j.cell.2019.04.024
– ident: ref149/cit149
  doi: 10.3233/JAD-190711
– ident: ref32/cit32
  doi: 10.1016/j.cub.2011.09.040
– ident: ref55/cit55
  doi: 10.1093/toxsci/kfw081
– ident: ref47/cit47
  doi: 10.1155/2013/623241
– ident: ref60/cit60
  doi: 10.1124/mol.108.046771
– ident: ref99/cit99
  doi: 10.1016/j.bbagen.2012.11.020
– ident: ref33/cit33
  doi: 10.1016/j.jtemb.2016.02.006
– ident: ref1/cit1
  doi: 10.1016/j.cell.2011.10.033
– ident: ref196/cit196
  doi: 10.1136/jnnp-2012-302883
– ident: ref169/cit169
  doi: 10.1016/j.tibs.2016.09.002
– ident: ref204/cit204
  doi: 10.4049/jimmunol.1100620
– ident: ref83/cit83
  doi: 10.1021/acs.accounts.9b00248
– ident: ref29/cit29
  doi: 10.1007/s00401-013-1177-7
– ident: ref59/cit59
  doi: 10.1007/978-3-319-60189-2_10
– ident: ref85/cit85
  doi: 10.1080/15548627.2020.1810918
– ident: ref134/cit134
  doi: 10.3389/fcell.2021.653815
– ident: ref81/cit81
  doi: 10.1038/s41419-020-2298-2
– ident: ref120/cit120
  doi: 10.1196/annals.1306.012
– ident: ref212/cit212
  doi: 10.1111/jcpe.13258
– ident: ref4/cit4
  doi: 10.1126/science.abf0529
– ident: ref160/cit160
  doi: 10.1016/S0966-842X(00)01936-3
– ident: ref74/cit74
  doi: 10.1080/15548627.2023.2165323
– ident: ref178/cit178
  doi: 10.1038/nature18590
– ident: ref23/cit23
  doi: 10.1001/jama.2009.1913
– ident: ref198/cit198
  doi: 10.1002/glia.22686
– ident: ref18/cit18
  doi: 10.1016/S0140-6736(20)32205-4
– ident: ref37/cit37
  doi: 10.1016/j.bbamcr.2020.118867
– ident: ref56/cit56
  doi: 10.1371/journal.pone.0031302
– ident: ref89/cit89
  doi: 10.1038/s41568-022-00459-0
– ident: ref142/cit142
  doi: 10.1038/onc.2017.11
– ident: ref176/cit176
  doi: 10.1038/s41467-017-02682-y
– ident: ref6/cit6
  doi: 10.1016/j.jalz.2010.11.007
– ident: ref147/cit147
  doi: 10.1038/nature24016
– ident: ref130/cit130
  doi: 10.1186/2051-5960-2-63
– ident: ref28/cit28
  doi: 10.1016/j.cell.2015.12.056
– ident: ref202/cit202
  doi: 10.3233/JAD-2012-121222
– ident: ref36/cit36
  doi: 10.1002/anie.202108961
– ident: ref106/cit106
  doi: 10.3389/fncel.2020.00231
– ident: ref86/cit86
  doi: 10.1016/j.cmet.2020.10.011
– ident: ref68/cit68
  doi: 10.1016/j.jinorgbio.2016.10.009
– ident: ref154/cit154
  doi: 10.1038/mp.2017.146
– ident: ref167/cit167
  doi: 10.3760/cma.j.issn.1671-8925.2017.11.021
– ident: ref133/cit133
  doi: 10.3233/JAD-132477
– ident: ref211/cit211
  doi: 10.1038/s41467-021-22301-1
– ident: ref171/cit171
  doi: 10.1038/nri3452
– ident: ref137/cit137
  doi: 10.1046/j.1471-4159.2002.t01-1-01061.x
– ident: ref70/cit70
  doi: 10.1016/j.jtemb.2014.05.003
– ident: ref54/cit54
  doi: 10.1021/bi0620961
– ident: ref150/cit150
  doi: 10.1038/srep35514
– ident: ref51/cit51
  doi: 10.1007/s00775-009-0600-y
– ident: ref97/cit97
  doi: 10.1016/j.chembiol.2020.03.012
– ident: ref146/cit146
  doi: 10.1016/j.neuron.2021.01.005
– ident: ref206/cit206
  doi: 10.1016/j.neurobiolaging.2007.06.006
– ident: ref174/cit174
  doi: 10.1016/j.biopha.2019.109595
– ident: ref65/cit65
  doi: 10.1016/j.peptides.2007.08.022
– ident: ref126/cit126
  doi: 10.7150/thno.59776
– ident: ref155/cit155
  doi: 10.1007/s12031-016-0839-z
– ident: ref113/cit113
  doi: 10.16476/j.pibb.2019.0057
– ident: ref145/cit145
  doi: 10.3760/cma.j.issn.0254-9026.2021.04.004
– ident: ref72/cit72
  doi: 10.1016/j.tox.2011.03.001
– ident: ref203/cit203
  doi: 10.1016/j.brainres.2014.08.040
– ident: ref140/cit140
  doi: 10.1016/j.redox.2017.11.001
– ident: ref164/cit164
  doi: 10.1038/s41590-021-00886-5
– ident: ref43/cit43
  doi: 10.1155/2013/623241
– ident: ref27/cit27
  doi: 10.1016/bs.pmbts.2016.12.016
– ident: ref109/cit109
  doi: 10.2174/1389450043345272
– ident: ref182/cit182
  doi: 10.1038/s41392-020-0145-7
– ident: ref101/cit101
  doi: 10.1016/j.cell.2013.12.010
– ident: ref193/cit193
  doi: 10.1523/JNEUROSCI.3238-09.2009
– ident: ref41/cit41
  doi: 10.1038/s41568-021-00417-2
– ident: ref76/cit76
  doi: 10.1016/j.cell.2012.03.042
– ident: ref19/cit19
  doi: 10.3760/cma.j.issn.0254-9026.2021.03.001
– ident: ref30/cit30
  doi: 10.1016/j.biopsych.2013.04.011
– ident: ref8/cit8
  doi: 10.1016/S1474-4422(16)00062-4
– ident: ref125/cit125
  doi: 10.3233/JAD-170543
– ident: ref156/cit156
  doi: 10.1038/s41380-022-01568-w
– ident: ref39/cit39
  doi: 10.1038/s41598-020-64521-3
– ident: ref112/cit112
  doi: 10.1007/s13311-019-00755-y
– ident: ref175/cit175
  doi: 10.1038/nature15632
– ident: ref139/cit139
  doi: 10.1016/j.freeradbiomed.2018.09.033
– ident: ref115/cit115
  doi: 10.3233/JAD-179944
– ident: ref14/cit14
  doi: 10.1016/j.jalz.2012.11.006
– ident: ref34/cit34
  doi: 10.1016/j.mam.2005.07.010
– ident: ref127/cit127
  doi: 10.1186/s12974-020-01976-1
– ident: ref213/cit213
  doi: 10.1016/j.atherosclerosis.2022.03.005
– ident: ref63/cit63
  doi: 10.1002/bip.20335
– ident: ref96/cit96
  doi: 10.1016/j.cell.2017.11.048
– ident: ref197/cit197
  doi: 10.1001/jama.2010.1553
– ident: ref67/cit67
  doi: 10.3390/foods10040869
– ident: ref209/cit209
  doi: 10.1007/s12035-014-9070-5
– ident: ref75/cit75
  doi: 10.1016/S1535-6108(03)00050-3
– ident: ref9/cit9
  doi: 10.3760/cma.j.cn113694-20211004-00679
– ident: ref163/cit163
  doi: 10.1016/S1097-2765(02)00599-3
– ident: ref117/cit117
  doi: 10.3390/medsci6020045
– ident: ref82/cit82
  doi: 10.3389/fphys.2019.00139
– ident: ref98/cit98
  doi: 10.1016/j.nut.2006.10.006
– ident: ref20/cit20
  doi: 10.3760/cma.j.issn.0376-2491.2018.13.004
– ident: ref73/cit73
  doi: 10.1073/pnas.1302212110
– ident: ref148/cit148
  doi: 10.3233/JAD-180514
– ident: ref152/cit152
  doi: 10.1001/jamaneurol.2016.4406
– ident: ref57/cit57
  doi: 10.1038/embor.2013.15
– ident: ref165/cit165
  doi: 10.1146/annurev-immunol-032712-095944
– ident: ref12/cit12
  doi: 10.1016/j.jalz.2012.11.007
– ident: ref205/cit205
  doi: 10.2174/156720511794604543
– ident: ref121/cit121
  doi: 10.1007/s10534-018-0126-2
– ident: ref177/cit177
  doi: 10.1038/nature18629
– ident: ref92/cit92
  doi: 10.1038/s41392-020-00428-9
– ident: ref187/cit187
  doi: 10.1016/j.bbi.2016.12.014
– ident: ref71/cit71
  doi: 10.1016/j.tiv.2007.07.011
– ident: ref124/cit124
  doi: 10.1016/j.neulet.2009.12.035
– ident: ref159/cit159
  doi: 10.1038/358167a0
– ident: ref50/cit50
  doi: 10.1016/j.jtemb.2012.04.012
– ident: ref61/cit61
  doi: 10.1128/MCB.24.2.865-874.2004
– ident: ref186/cit186
  doi: 10.1038/nature11729
– ident: ref153/cit153
  doi: 10.1016/j.pneurobio.2020.101904
– ident: ref172/cit172
  doi: 10.14348/molcells.2014.0104
– ident: ref136/cit136
  doi: 10.1046/j.1471-4159.2000.0741749.x
– ident: ref31/cit31
  doi: 10.12114/j.issn.1007-9572.2021.02.031
– ident: ref5/cit5
  doi: 10.1016/j.jalz.2007.04.381
– ident: ref64/cit64
  doi: 10.1016/j.peptides.2005.09.002
– ident: ref11/cit11
  doi: 10.1111/joim.12959
– ident: ref157/cit157
  doi: 10.1186/s13045-020-00946-7
– ident: ref40/cit40
  doi: 10.1074/jbc.R117.000176
– ident: ref62/cit62
  doi: 10.1016/j.cell.2020.10.029
– ident: ref129/cit129
  doi: 10.1007/s00401-012-0987-3
– ident: ref214/cit214
  doi: 10.3389/fimmu.2021.770744
– ident: ref185/cit185
  doi: 10.1038/ni.1636
– ident: ref191/cit191
  doi: 10.1016/j.jchemneu.2005.07.003
– ident: ref25/cit25
  doi: 10.1056/NEJMoa2212948
– ident: ref128/cit128
  doi: 10.1038/s41589-019-0462-8
– ident: ref144/cit144
  doi: 10.1016/j.freeradbiomed.2013.01.026
– ident: ref13/cit13
  doi: 10.1186/s13195-016-0188-8
– ident: ref24/cit24
  doi: 10.12114/j.issn.1007-9572.2021.00.121
– ident: ref102/cit102
  doi: 10.3389/fnins.2019.01443
– ident: ref119/cit119
  doi: 10.1186/s40035-022-00313-1
– ident: ref180/cit180
  doi: 10.1038/nature06616
– volume: 75
  start-page: 391
  issue: 4
  year: 2015
  ident: ref105/cit105
  publication-title: Acta. Neurobiol. Exp. (Wars)
  doi: 10.55782/ane-2015-2044
  contributor:
    fullname: Kwiatek-Majkusiak J.
– ident: ref173/cit173
  doi: 10.1016/j.arr.2020.101192
– ident: ref2/cit2
  doi: 10.1038/s41580-020-0270-8
– ident: ref170/cit170
  doi: 10.4049/jimmunol.0901363
– ident: ref95/cit95
  doi: 10.1016/j.bbalip.2013.10.018
– ident: ref181/cit181
  doi: 10.1016/j.cell.2013.03.030
– ident: ref45/cit45
  doi: 10.1586/ern.11.170
– ident: ref158/cit158
  doi: 10.1038/s41392-020-0180-4
– ident: ref138/cit138
  doi: 10.1016/j.redox.2013.07.004
– ident: ref132/cit132
  doi: 10.1523/JNEUROSCI.5245-10.2011
– ident: ref84/cit84
  doi: 10.1093/cercor/bhx045
– ident: ref78/cit78
  doi: 10.1038/cdd.2015.158
– ident: ref210/cit210
  doi: 10.3760/cma.j.issn.1673-4394.2022.06.015
– ident: ref90/cit90
  doi: 10.1038/nchembio.2239
– ident: ref53/cit53
  doi: 10.1107/S1744309107041139
– ident: ref17/cit17
  doi: 10.1097/WCO.0000000000000911
– ident: ref49/cit49
  doi: 10.3233/JAD-143108
– ident: ref201/cit201
  doi: 10.1038/npp.2013.208
– ident: ref122/cit122
  doi: 10.1155/2018/2850341
– ident: ref166/cit166
  doi: 10.1002/eji.200940185
– ident: ref189/cit189
  doi: 10.1038/ncomms3909
– ident: ref183/cit183
  doi: 10.1038/nri3705
– ident: ref66/cit66
  doi: 10.1016/j.bbrc.2007.04.191
– ident: ref108/cit108
  doi: 10.1016/j.redox.2017.01.021
– ident: ref35/cit35
  doi: 10.1093/ajcn/63.5.797
– ident: ref143/cit143
  doi: 10.1016/j.redox.2017.01.021
– ident: ref107/cit107
  doi: 10.3389/fnbeh.2020.00152
– ident: ref94/cit94
  doi: 10.1073/pnas.0712245105
– ident: ref58/cit58
  doi: 10.3389/fphys.2013.00111
– ident: ref116/cit116
  doi: 10.15252/emmm.201606210
– ident: ref131/cit131
  doi: 10.1074/jbc.M111.237974
– ident: ref141/cit141
  doi: 10.1038/cddis.2016.208
– ident: ref199/cit199
  doi: 10.1016/S1474-4422(14)70017-1
– ident: ref200/cit200
  doi: 10.15252/embj.2018101064
– ident: ref77/cit77
  doi: 10.1038/s41418-017-0012-4
SSID ssj0069086
Score 2.425885
SecondaryResourceType review_article
Snippet Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder characterized by progressive cognitive dysfunction. Epidemiological...
SourceID proquest
crossref
acs
SourceType Aggregation Database
Publisher
StartPage 3564
Title Ferroptosis, Pyroptosis, and Cuproptosis in Alzheimer’s Disease
URI http://dx.doi.org/10.1021/acschemneuro.3c00343
https://search.proquest.com/docview/2864899540
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bS8MwFA46X3zxNsV5I4IIgp1tk94ex-aYihfQgW8lSRMcunas3cP25N_w7_lLPGlX5hRRX0opoS0nOTnfl3ND6Mi2uEMFEYZyImZQzkDnXFMZkedqQOBGJtfZyNc3bqdLLx-dxxlR_OrBt60zJoDmyX5e3rFOhC6oQhbRkq2DCDUUat6XOy8QvbyzI_By3_AAmZSpcj-8RRskkc4bpPn9ODcy7VV0W6bqFLElz_VRxuti8r1y4x__fw2tTPEmbhQLZB0tyHgDVRsxcO3-GB_jPAI0P1qvokZbDofJIEvSXnqK78azexZHuDkalA9wL8aNl8mT7PXl8P31LcWtws-zibrt84dmx5i2WDAYsZ3MsGzFQQ1N5gKOsCKluOtz2wsiFTCLe0QqQQJBlOQRdR3JiC8DFXHq-YoqIT2yhSpxEstthGUgALwAegCSQgPAXZ6SPgwWltLOOllDJyCKcKoiaZh7v20r_CyfcCqfGjLKOQkHRdWNX8YflhMXgnponweLZTJKQ9t3qa9r3pk7__j-LlrWbeXzoD26hyrZcCT3AXxk_CBfcXBtXVx9APCC2kU
link.rule.ids 315,786,790,2782,27109,27957,27958,57093,57143
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LSwMxEB60HvTiW6zPCCIIbu1usq9jqZb6RLAVb8smm2DRbkt3e6gn_4Z_z1_iJO36AhFvSwjZZJLJfJN5Aew7NneZoMJSbhJbjMfIc15VWYnvaUDgJVWuo5Gvrr1mm53fu_dT4BaxMDiJDEfKjBH_M7uAfYxtuIquyfJYoULnVaHTMOP6qJJrRFS_LS5g1PdMgUdUzwPLR4BSRMz9MoqWSyL7Lpe-X8tG1jQW4O5jlsbF5LEyzHlFPP9I4PjvZSzC_AR9ktr4uCzBlEyXYaWWoubdHZEDYvxBzUP7CtQacjDo9fNe1smOyM3o8ztOE1If9osG0klJ7en5QXa6cvD28pqRk7HVZxXajdNWvWlNCi5YMXXc3LIdxZEpq7GHqMJOlOJewB0_TFQY29ynUgkaCqokT5jnypgGMlQJZ36gmBLSp2tQSnupXAciQ4FQBrEEqiwsRBTmKxlgZ2ErbbqTZThEUkQThskiYwt37OgrfaIJfcpgFVsT9cc5OP7ov1fsX4TMoi0gcSp7wyxyAo8FOgNedeMf_9-F2Wbr6jK6PLu-2IQ5XXDeuPOxLSjlg6HcRliS8x1zCN8BXNbhtw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ZSwMxEA4eIL54VbGeEUQQ3NrdZK_H0lrqiaCF4suyubBot6W7fbBP_g3_nr_ESbrrBSL6toSQTSaZ5JvM5BuE9h2buZQTbilXxBZlMeicV1WW8D0NCDxRZfo18uWV12rTs47b-ZTqCzqRQkupceJrrR4IlTMM2MdQDiPpGabHCuGaW4VMo1lX5_DWqKh-U2zCYPOZJI9gogeWDyCleDX3Qyv6bOLp17Pp69ZszpvmIrp776kJM3mojDJW4eNvJI7_GsoSWshRKK5Nls0ympLJCirVErDAe0_4AJu4UHPhXkK1phwO-4Osn3bTI3z99PEdJwLXR4OiAHcTXHsc38tuTw5fn19S3Jh4f1ZRu3lyW29ZeeIFKyaOm1m2oxgoZzX2AF3YQinmBczxQ6HC2GY-kYqTkBMlmaCeK2MSyFAJRv1AUcWlT9bQTNJP5DrCMuQAaQBTgOlCQ0BjvpIBVOa20i48WUaHIIooV5w0Mj5xx44-yyfK5VNGVjE90WDCxfFL_b1iDiNQGu0JiRPZH6WRE3g00Ex41Y0__H8XzV03mtHF6dX5JprXeedNVB_dQjPZcCS3AZ1kbMeswzeJaOQx
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Ferroptosis%2C+Pyroptosis%2C+and+Cuproptosis+in+Alzheimer%27s+Disease&rft.jtitle=ACS+chemical+neuroscience&rft.au=Wang%2C+Qi&rft.au=Sun%2C+Jingyi&rft.au=Chen%2C+Tian&rft.au=Song%2C+Siyu&rft.date=2023-10-04&rft.eissn=1948-7193&rft.volume=14&rft.issue=19&rft.spage=3564&rft.epage=3587&rft_id=info:doi/10.1021%2Facschemneuro.3c00343&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1948-7193&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1948-7193&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1948-7193&client=summon