Mild Hyperthermia-Assisted ROS Scavenging Hydrogels Achieve Diabetic Wound Healing
Excessive reactive oxygen species (ROS) production induces oxidative damage to biomolecules, which can lead to the development of chronic diseases. Biocompatible hydrogel antioxidants composed of natural materials, such as polysaccharides and polyphenols, are of significant option for ROS scavenging...
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| Published in | ACS macro letters Vol. 11; no. 7; pp. 861 - 867 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
American Chemical Society
19.07.2022
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| Online Access | Get full text |
| ISSN | 2161-1653 2161-1653 |
| DOI | 10.1021/acsmacrolett.2c00290 |
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| Abstract | Excessive reactive oxygen species (ROS) production induces oxidative damage to biomolecules, which can lead to the development of chronic diseases. Biocompatible hydrogel antioxidants composed of natural materials, such as polysaccharides and polyphenols, are of significant option for ROS scavenging. However, rapidly achieving hydrogel antioxidants with convenient, economical, safe, and efficient features remains challenging. Herein, facile synthesis of a physically cross-linked polyphenol/polysaccharide hydrogel by introducing tannic acid microsize particles (TAMP) into a cationic guar gum (CG) matrix is reported. Combining antioxidant/photothermal properties of TAMP and mechanical support from injectable CG, the formulated TAMP/CG is explored for treating diabetic wounds. Both in vitro and in vivo assays verify that TAMP/CG can protect the cells from ROS-induced oxidative damage, which can also be strengthened by the local photothermal heating (42 °C) triggered by near-infrared light. Overall, this study establishes the paradigm of enhanced diabetic wound healing by mild hyperthermia-assisted ROS scavenging hydrogels. |
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| AbstractList | Excessive reactive oxygen species (ROS) production induces oxidative damage to biomolecules, which can lead to the development of chronic diseases. Biocompatible hydrogel antioxidants composed of natural materials, such as polysaccharides and polyphenols, are of significant option for ROS scavenging. However, rapidly achieving hydrogel antioxidants with convenient, economical, safe, and efficient features remains challenging. Herein, facile synthesis of a physically cross-linked polyphenol/polysaccharide hydrogel by introducing tannic acid microsize particles (TAMP) into a cationic guar gum (CG) matrix is reported. Combining antioxidant/photothermal properties of TAMP and mechanical support from injectable CG, the formulated TAMP/CG is explored for treating diabetic wounds. Both in vitro and in vivo assays verify that TAMP/CG can protect the cells from ROS-induced oxidative damage, which can also be strengthened by the local photothermal heating (42 °C) triggered by near-infrared light. Overall, this study establishes the paradigm of enhanced diabetic wound healing by mild hyperthermia-assisted ROS scavenging hydrogels.Excessive reactive oxygen species (ROS) production induces oxidative damage to biomolecules, which can lead to the development of chronic diseases. Biocompatible hydrogel antioxidants composed of natural materials, such as polysaccharides and polyphenols, are of significant option for ROS scavenging. However, rapidly achieving hydrogel antioxidants with convenient, economical, safe, and efficient features remains challenging. Herein, facile synthesis of a physically cross-linked polyphenol/polysaccharide hydrogel by introducing tannic acid microsize particles (TAMP) into a cationic guar gum (CG) matrix is reported. Combining antioxidant/photothermal properties of TAMP and mechanical support from injectable CG, the formulated TAMP/CG is explored for treating diabetic wounds. Both in vitro and in vivo assays verify that TAMP/CG can protect the cells from ROS-induced oxidative damage, which can also be strengthened by the local photothermal heating (42 °C) triggered by near-infrared light. Overall, this study establishes the paradigm of enhanced diabetic wound healing by mild hyperthermia-assisted ROS scavenging hydrogels. Excessive reactive oxygen species (ROS) production induces oxidative damage to biomolecules, which can lead to the development of chronic diseases. Biocompatible hydrogel antioxidants composed of natural materials, such as polysaccharides and polyphenols, are of significant option for ROS scavenging. However, rapidly achieving hydrogel antioxidants with convenient, economical, safe, and efficient features remains challenging. Herein, facile synthesis of a physically cross-linked polyphenol/polysaccharide hydrogel by introducing tannic acid microsize particles (TAMP) into a cationic guar gum (CG) matrix is reported. Combining antioxidant/photothermal properties of TAMP and mechanical support from injectable CG, the formulated TAMP/CG is explored for treating diabetic wounds. Both in vitro and in vivo assays verify that TAMP/CG can protect the cells from ROS-induced oxidative damage, which can also be strengthened by the local photothermal heating (42 °C) triggered by near-infrared light. Overall, this study establishes the paradigm of enhanced diabetic wound healing by mild hyperthermia-assisted ROS scavenging hydrogels. |
| Author | Pan, Wenhao Hu, Rongdang Zhang, Chenhao Cai, Erya You, Shengye Shen, Jianliang Tong, Xianqin Qi, Xiaoliang Mao, Ruiting |
| AuthorAffiliation | State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health) School and Hospital of Stomatology Wenzhou Institute University of Chinese Academy of Sciences |
| AuthorAffiliation_xml | – name: University of Chinese Academy of Sciences – name: Wenzhou Institute – name: Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health) – name: School and Hospital of Stomatology – name: State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering |
| Author_xml | – sequence: 1 givenname: Xiaoliang orcidid: 0000-0002-2480-7242 surname: Qi fullname: Qi, Xiaoliang organization: State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering – sequence: 2 givenname: Xianqin surname: Tong fullname: Tong, Xianqin organization: School and Hospital of Stomatology – sequence: 3 givenname: Shengye surname: You fullname: You, Shengye organization: School and Hospital of Stomatology – sequence: 4 givenname: Ruiting surname: Mao fullname: Mao, Ruiting organization: School and Hospital of Stomatology – sequence: 5 givenname: Erya surname: Cai fullname: Cai, Erya organization: School and Hospital of Stomatology – sequence: 6 givenname: Wenhao surname: Pan fullname: Pan, Wenhao organization: School and Hospital of Stomatology – sequence: 7 givenname: Chenhao surname: Zhang fullname: Zhang, Chenhao organization: School and Hospital of Stomatology – sequence: 8 givenname: Rongdang surname: Hu fullname: Hu, Rongdang email: hurongdang@hotmail.com organization: School and Hospital of Stomatology – sequence: 9 givenname: Jianliang orcidid: 0000-0003-4351-4872 surname: Shen fullname: Shen, Jianliang email: shenjl@wibe.ac.cn organization: Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health) |
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