Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation: A Randomized Clinical Trial

• Published in: JAMA : the journal of the American Medical Association Vol. 325; no. 11; pp. 1061 - 1073
• Main Authors: Albert, Christine M, Cook, Nancy R, Pester, Julie, Moorthy, M. Vinayaga, Ridge, Claire, Danik, Jacqueline S, Gencer, Baris, Siddiqi, Hasan K, Ng, Chee, Gibson, Heike, Mora, Samia, Buring, Julie E, Manson, JoAnn E
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 16.03.2021
• Subjects: Aged; Atrial Fibrillation - drug therapy; Cholecalciferol - therapeutic use; Dietary Supplements; Docosahexaenoic Acids - therapeutic use; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Eicosapentaenoic Acid - therapeutic use; Female; Humans; Male; Middle Aged; Original Investigation; Treatment Failure; Vitamin D Deficiency - drug therapy; Vitamins - therapeutic use

IMPORTANCE: Atrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and vitamin D have been reported to ha...