Alkaline Phosphatase-Controllable and Red Light-Activated RNA Modification Approach for Precise Tumor Suppression

• Published in: Journal of the American Chemical Society Vol. 144; no. 50; pp. 23061 - 23072
• Main Authors: Fang, Jing, Feng, Yali, Zhang, Yuqi, Wang, Anna, Li, Jiachen, Cui, Chaoxiang, Guo, Yirui, Zhu, Jinfeng, Lv, Zhengzhong, Zhao, Zhongsheng, Xu, Chenjie, Shi, Haibin
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 21.12.2022; Amer Chemical Soc
• Subjects: Alkaline Phosphatase; Chemistry; Chemistry, Multidisciplinary; Fluorescent Dyes - chemistry; Humans; Light; Neoplasms; Physical Sciences; RNA; Science & Technology; STRATEGY; MITOCHONDRIA; CROSS-LINKING; RECEPTOR; SELECTIVE DETECTION; DELIVERY; PROBES

RNA interference (RNAi) has proved to be a promising modality for disease treatment. However, the promise of conventional RNA therapeutics for clinical application is severely impeded by low delivery efficiency and susceptibility of RNAs to serum RNases. Therefore, developing advanced RNAi technolog...