The Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes

• Published in: Journal of the American Chemical Society Vol. 141; no. 36; pp. 14168 - 14179
• Main Authors: Levine, Zachary A, Teranishi, Kazuki, Okada, Alan K, Langen, Ralf, Shea, Joan-Emma
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.09.2019

Mitochondrially derived peptides (MDPs) such as humanin (HN) have shown a remarkable ability to modulate neurological amyloids and apoptosis-associated proteins in cells and animal models. Recently, we found that humanin-like peptides also inhibit amyloid formation outside of neural environments in...