The Current State of Critical Limb Ischemia: A Systematic Review

• Published in: JAMA surgery Vol. 151; no. 11; p. 1070
• Main Authors: Farber, Alik, Eberhardt, Robert T
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 01.11.2016
• Subjects: Amputation, Surgical; Chronic Disease; Diabetes Complications - complications; Diabetes Mellitus - drug therapy; Humans; Hyperbaric Oxygenation; Hyperlipidemias - drug therapy; Hypertension - drug therapy; Ischemia - diagnosis; Ischemia - epidemiology; Ischemia - etiology; Ischemia - therapy; Lower Extremity - blood supply; Peripheral Arterial Disease - complications; Peripheral Arterial Disease - surgery; Platelet Aggregation Inhibitors - therapeutic use; Smoking - adverse effects; Smoking Cessation; Upper Extremity - blood supply

IMPORTANCE: Chronic critical limb ischemia, marked by intractable lower extremity ischemic rest pain and tissue loss, is a highly morbid condition that leads to the loss of ambulation and decreased quality of life. It is associated with a high risk of limb loss and mortality and presents a significa...