Rhodium-Catalyzed Carbonylative Synthesis of Aryl Salicylates from Unactivated Phenols

• Published in: Organic letters Vol. 22; no. 15; pp. 6050 - 6054
• Main Authors: Ai, Han-Jun, Zhang, Youcan, Zhao, Fengqian, Wu, Xiao-Feng
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 07.08.2020; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; OXIDATIVE CARBONYLATION; MIGRATION; PHOSGENE; DIMETHYL CARBONATE; FRIES REARRANGEMENT; SMILES REARRANGEMENT; DIPHENYL CARBONATE; C-C; INTERNAL ALKYNES; CLEAVAGE

A rhodium-catalyzed carbonylative transformation of unactivated phenols to aryl salicylates is described. This protocol is characterized by utilizing 1,3-rhodium migration as the key step to provide direct access to synthesize o-hydroxyaryl esters. Various desired aryl o-hydroxybenzoates were produc...