Photocatalytic Umpolung Strategy for the Synthesis of α‑Amino Phosphine Oxides and Deuterated Derivatives

• Published in: Organic letters Vol. 25; no. 44; pp. 8016 - 8021
• Main Authors: Ma, Chunhua, Li, Xiaofeng, Chen, Xiya, He, Xing, Zhang, Shu-Ting, Jiang, Yu-Qin, Yu, Bing
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 10.11.2023; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; 2-ISOCYANOBIPHENYLS; KABACHNIK-FIELDS REACTION; PHOSPHONATES; RADICAL C-P; ISOCYANIDES; GENERATION; EFFICIENT; CYCLIZATION; AMINOPHOSPHONATES; SOLVENT

Direct, economical, and green synthesis of deuterated α-amino phosphine oxides remains an elusive challenge in synthetic chemistry. Herein, we report a visible-light-driven umpolung strategy for synthesizing deuterated α-amino phosphine oxides from isocyanide using 1,2,3,5-tetrakis­(carbazol-9-yl)-4...