Nickel-Catalyzed C–S Reductive Cross-Coupling of Alkyl Halides with Arylthiosilanes toward Alkyl Aryl Thioethers

• Published in: Organic letters Vol. 24; no. 28; pp. 5115 - 5119
• Main Authors: Yang, Yu-Zhong, Li, Yang, Lv, Gui-Fen, He, De-Liang, Li, Jin-Heng
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 22.07.2022; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; SYSTEM; THIOLS; DESIGN; SULFIDES; ARYLATION; CHLORIDES; BOND FORMATION; FACILE; EFFICIENT; DISULFIDES

A nickel-catalyzed C–S reductive cross-coupling of alkyl halides with arylthiosilanes for producing alkyl aryl thioethers is developed. This reaction is initiated by umpolung transformations of arylthiosilanes followed by C–S reductive cross-coupling with alkyl halides to manage an electrophilic alk...