Multicomponent Cascade Reaction of 3‑Formylchromones: Highly Selective Synthesis of Functionalized 9‑Azabicyclo[3.3.1]nonane Derivatives

• Published in: Organic letters Vol. 23; no. 17; pp. 6866 - 6871
• Main Authors: Duan, Ying-Gang, Hu, Xing-Mei, Cao, Xin-Ling, Lv, Kai-Hong, Yan, Sheng-Jiao
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 03.09.2021; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; CHROMONE; 1,1-ENEDIAMINES SYNTHESIS; ISATINS; SITES; RECEPTOR; COCAINE; ENAMINES; CYCLIZATION; DISCOVERY

A novel protocol for the preparation of functionalized 9-azabicyclo[3.3.1]­nonane (ABCN) derivatives from 3-formylchromones, enaminones, and heterocyclic ketene aminals (HKAs) through an unprecedented cascade reaction has been developed by simply refluxing the mixture of the substrates 1–3. As a res...