Visible-Light-Enabled Lanthanum-Mediated Intramolecular Epoxy-Ring Opening/Dehydrogenative Lactonization

• Published in: Organic letters Vol. 25; no. 39; pp. 7126 - 7131
• Main Authors: Cai, Lina, Lai, Qihong, Zhang, Lele, Xue, Guotao, Zhang, Yirui, He, Na, Huang, Mingqiang, Hu, Shirong, Cai, Shunyou
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 06.10.2023; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; CATALYSIS; ACTIVATION; ALKYNES; ALKYLATION; C-H BONDS; PHOTOCATALYSIS

Catalytic C­(sp3)–H functionalization has afforded great opportunities to prepare organic substances, facilitating the derivatization of complex drugs and natural molecules. This letter describes an efficient and practical protocol for lanthanum-catalyzed continuous epoxy-ring opening and oxidative...