An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice

• Published in: Journal of the American Chemical Society Vol. 141; no. 45; pp. 17973 - 17977
• Main Authors: Chen, Zhongyan, Mu, Xueling, Han, Zhong, Yang, Shiping, Zhang, Changli, Guo, Zijian, Bai, Yang, He, Weijiang
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 13.11.2019; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Multidisciplinary; fluorescence; hydrogen sulfide; image analysis; intravenous injection; liver; mice; Physical Sciences; S-adenosylmethionine; Science & Technology; DYE; SIGNALING PATHWAYS; NANOPROBE; STRATEGY; HYDROGEN-SULFIDE; LEVEL; CANCER; FLUORESCENCE PROBES

Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was sugg...