An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice
Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was sugg...
Saved in:
| Published in | Journal of the American Chemical Society Vol. 141; no. 45; pp. 17973 - 17977 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
13.11.2019
Amer Chemical Soc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H2S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H2S, profiting from a keto–enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H2S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging. |
|---|---|
| AbstractList | Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H2S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H2S, profiting from a keto-enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H2S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging. Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H2S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H2S, profiting from a keto–enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H2S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging. Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H2S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H2S, profiting from a keto-enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H2S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging.Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H2S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H2S, profiting from a keto-enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H2S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging. Tracking signaling H₂S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H₂S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H₂S, profiting from a keto–enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H₂S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging. |
| Author | Yang, Shiping Mu, Xueling Zhang, Changli Guo, Zijian Chen, Zhongyan Han, Zhong Bai, Yang He, Weijiang |
| AuthorAffiliation | Chemistry and Biomedicine Innovation Center State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering Key Laboratory of Resource Chemistry |
| AuthorAffiliation_xml | – name: Key Laboratory of Resource Chemistry – name: Chemistry and Biomedicine Innovation Center – name: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering |
| Author_xml | – sequence: 1 givenname: Zhongyan surname: Chen fullname: Chen, Zhongyan organization: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering – sequence: 2 givenname: Xueling surname: Mu fullname: Mu, Xueling organization: Key Laboratory of Resource Chemistry – sequence: 3 givenname: Zhong surname: Han fullname: Han, Zhong organization: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering – sequence: 4 givenname: Shiping orcidid: 0000-0001-7527-4581 surname: Yang fullname: Yang, Shiping email: shipingy@shnu.edu.cn organization: Key Laboratory of Resource Chemistry – sequence: 5 givenname: Changli surname: Zhang fullname: Zhang, Changli organization: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering – sequence: 6 givenname: Zijian orcidid: 0000-0003-4986-9308 surname: Guo fullname: Guo, Zijian email: zguo@nju.edu.cn organization: Chemistry and Biomedicine Innovation Center – sequence: 7 givenname: Yang surname: Bai fullname: Bai, Yang organization: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering – sequence: 8 givenname: Weijiang orcidid: 0000-0002-3157-5769 surname: He fullname: He, Weijiang email: heweij69@nju.edu.cn organization: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering |
| BookMark | eNqNUclOwzAUtBAIynLjA3xEQqF-dhaHGypbpSIQ29VyHLu4SuySOCx_jwNIXDm9N9LM05uZXbTpvNMIHQI5AUJhupKqPykrUgKHDTSBjJIkA5pvogkhhCYFz9kO2u37VYQp5bCNdhjkWREFExTOHL5dB6tkM7178cFL5Yc-Ynw-yCa58bVsbPjEd52v9Cm-l8H6VocuEqyb6g_8bN88nrdyad0SG9_hh2DboZFB1_iaPuCndaeXI7beRQm-sUrvoy0jm14f_M499Hh58Ti7Tha3V_PZ2SKRjJKQ1DVkeaUryrmqjSqorKgxOeFpybO0lqysDM8KnYJknEP0TAnNualZVpsC2B46-jm77vzroPsgWtsr3TTS6WhSUMYyYKRM839QgTACKR-v8h_qu6686ZXVTmmx7mwru08xZlzymHJOxnVmw7fzmR9ciNLj_0v_fooFi5UfOhezEkDEWLsYaxe_tbMvXeWdrg |
| Cites_doi | 10.1073/pnas.0509531103 10.1039/c4cs00086b 10.1038/nrd.2015.1 10.1016/j.ccr.2012.04.004 10.1021/acs.chemrev.6b00001 10.1002/anie.201104236 10.1016/j.neuropharm.2015.08.004 10.1039/b914348n 10.1073/pnas.1701976114 10.1021/jacs.5b04196 10.1002/anie.201710688 10.1021/acsami.8b08887 10.1002/adfm.201704689 10.1039/c5cs00005j 10.1039/c5sc04986e 10.1073/pnas.1206646109 10.1039/c6sc05646f 10.1126/science.1216210 10.1016/j.saa.2018.03.052 10.1039/c4cs00298a 10.1039/c6sc02500e 10.1038/nchembio.1913 10.1111/1440-1681.12238 10.1021/jacs.5b03248 10.1039/c7cs00612h 10.1126/science.1162667 10.1002/anie.201207701 10.1007/s10571-018-0632-3 10.1038/nrd2425 10.1002/adma.201606857 10.1039/c4cs00280f 10.1002/chem.201604473 |
| ContentType | Journal Article |
| DBID | 17B 1KM AAWJD BLEPL DTL EGQ 7X8 7S9 L.6 |
| DOI | 10.1021/jacs.9b09181 |
| DatabaseName | Web of Knowledge Index Chemicus Web of Science - Science Citation Index Expanded - 2019 Web of Science Core Collection Science Citation Index Expanded Web of Science Primary (SCIE, SSCI & AHCI) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | Web of Science MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | Web of Science MEDLINE - Academic AGRICOLA |
| Database_xml | – sequence: 1 dbid: 1KM name: Index Chemicus url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC sourceTypes: Enrichment Source Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1520-5126 |
| EndPage | 17977 |
| ExternalDocumentID | 000498281600004 b041209192 |
| GrantInformation_xml | – fundername: National Basic Research Program of China grantid: 2015CB856300 – fundername: National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) grantid: 21571099; 21977044; 21731004 |
| GroupedDBID | - .K2 02 53G 55A 5GY 5RE 5VS 7~N 85S AABXI ABFLS ABMVS ABPPZ ABPTK ABUCX ABUFD ACGFS ACJ ACNCT ACS AEESW AENEX AETEA AFEFF ALMA_UNASSIGNED_HOLDINGS AQSVZ BAANH BKOMP CS3 DU5 DZ EBS ED ED~ ET F5P GNL IH9 JG JG~ K2 LG6 P2P ROL RXW TAE TN5 UHB UI2 UKR UPT VF5 VG9 VQA W1F WH7 X XFK YZZ ZHY --- -DZ -ET -~X .DC 17B 1KM 4.4 AAHBH AAYWT ABBLG ABJNI ABLBI ABQRX ACBEA ACGFO ADHLV AGXLV AHDLI AHGAQ BLEPL CUPRZ DTL GGK GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED GROUPED_WOS_WEB_OF_SCIENCE IH2 XSW YQT ZCA ~02 7X8 7S9 EJD L.6 |
| ID | FETCH-LOGICAL-a320t-dd156beb288cdfc72ab2ff60849854da39bf857e41a388112620268fd35df713 |
| IEDL.DBID | ACS |
| ISICitedReferencesCount | 178 |
| ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000498281600004 |
| ISSN | 0002-7863 1520-5126 |
| IngestDate | Fri Jul 11 06:43:35 EDT 2025 Thu Jul 10 18:37:45 EDT 2025 Tue Jul 22 04:50:05 EDT 2025 Fri Aug 29 15:59:23 EDT 2025 Thu Aug 27 13:44:03 EDT 2020 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 45 |
| Keywords | DYE SIGNALING PATHWAYS NANOPROBE STRATEGY HYDROGEN-SULFIDE LEVEL CANCER FLUORESCENCE PROBES |
| Language | English |
| LinkModel | DirectLink |
| LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
| MergedId | FETCHMERGED-LOGICAL-a320t-dd156beb288cdfc72ab2ff60849854da39bf857e41a388112620268fd35df713 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-4986-9308 0000-0002-3157-5769 0000-0001-7527-4581 |
| PMID | 31657918 |
| PQID | 2310301481 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_2335130946 proquest_miscellaneous_2310301481 webofscience_primary_000498281600004 acs_journals_10_1021_jacs_9b09181 webofscience_primary_000498281600004CitationCount |
| ProviderPackageCode | JG~ 55A AABXI GNL VF5 7~N ACJ VG9 W1F ACS AEESW AFEFF .K2 ABMVS ABUCX IH9 BAANH AQSVZ ED~ UI2 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-11-13 |
| PublicationDateYYYYMMDD | 2019-11-13 |
| PublicationDate_xml | – month: 11 year: 2019 text: 2019-11-13 day: 13 |
| PublicationDecade | 2010 |
| PublicationPlace | WASHINGTON |
| PublicationPlace_xml | – name: WASHINGTON |
| PublicationTitle | Journal of the American Chemical Society |
| PublicationTitleAbbrev | J AM CHEM SOC |
| PublicationTitleAlternate | J. Am. Chem. Soc |
| PublicationYear | 2019 |
| Publisher | American Chemical Society Amer Chemical Soc |
| Publisher_xml | – name: American Chemical Society – name: Amer Chemical Soc |
| References | Harrison, IP (WOS:000340546400001) 2014; 41 Que, EL (WOS:000272711300005) 2010; 39 Klein, MO (WOS:000455226200003) 2019; 39 Wang, LHV (WOS:000301837000036) 2012; 335 Pablos, P (WOS:000366066800040) 2015; 99 Leal, SS (WOS:000308837100013) 2012; 256 Yang, GD (WOS:000260299100043) 2008; 322 Wang, R (WOS:000304991100016) 2012; 109 Weissleder, R (WOS:000167940700017) 2001; 19 Chen, YC (WOS:000357691200005) 2015; 44 Anees, P (WOS:000378715000019) 2016; 7 Chen, Q (WOS:000401797800033) 2017; 114 Zhang, XA (WOS:000247641900008) 2007; 104 Peng, HJ (WOS:000296205000031) 2011; 50 Zhao, BY (WOS:000432767100015) 2018; 199 Szabo, C (WOS:000250536300017) 2007; 6 Szabo, C (WOS:000371741300019) 2016; 15 Lin, VS (WOS:000357691200008) 2015; 44 Chang, CJ (WOS:000361536500001) 2015; 11 Chen, W (WOS:000418359400035) 2017; 56 Chen, FM (WOS:000442460400017) 2018; 10 Li, X (WOS:000403280600014) 2017; 29 Zhou, J (WOS:000384311700002) 2016; 7 Huang, XL (WOS:000430708600012) 2018; 47 Zhao, CC (WOS:000357964400034) 2015; 137 Sun, W (WOS:000380730100002) 2016; 116 Chen, M (WOS:000424152900006) 2018; 28 Al-Karmi, S (WOS:000393618700006) 2017; 23 Hammers, MD (WOS:000359962000041) 2015; 137 Lee, MH (WOS:000356610100003) 2015; 44 Zhang, K (WOS:000397560500034) 2017; 8 Chen, YC (WOS:000314650600011) 2013; 52 Prudova, A (WOS:000237151000015) 2006; 103 Nie, LM (WOS:000342880000012) 2014; 43 |
| References_xml | – volume: 103 start-page: 6489 year: 2006 ident: WOS:000237151000015 article-title: S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA doi: 10.1073/pnas.0509531103 – volume: 43 start-page: 7132 year: 2014 ident: WOS:000342880000012 article-title: Structural and functional photoacoustic molecular tomography aided by emerging contrast agents publication-title: CHEMICAL SOCIETY REVIEWS doi: 10.1039/c4cs00086b – volume: 15 start-page: 185 year: 2016 ident: WOS:000371741300019 article-title: Gasotransmitters in cancer: from pathophysiology to experimental therapy publication-title: NATURE REVIEWS DRUG DISCOVERY doi: 10.1038/nrd.2015.1 – volume: 256 start-page: 2253 year: 2012 ident: WOS:000308837100013 article-title: Metal ions as modulators of protein conformation and misfolding in neurodegeneration publication-title: COORDINATION CHEMISTRY REVIEWS doi: 10.1016/j.ccr.2012.04.004 – volume: 116 start-page: 7768 year: 2016 ident: WOS:000380730100002 article-title: Recent Development of Chemosensors Based on Cyanine Platforms publication-title: CHEMICAL REVIEWS doi: 10.1021/acs.chemrev.6b00001 – volume: 50 start-page: 9672 year: 2011 ident: WOS:000296205000031 article-title: A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION doi: 10.1002/anie.201104236 – volume: 99 start-page: 422 year: 2015 ident: WOS:000366066800040 article-title: Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of mu-opioid receptors in the rat locus coeruleus publication-title: NEUROPHARMACOLOGY doi: 10.1016/j.neuropharm.2015.08.004 – volume: 39 start-page: 51 year: 2010 ident: WOS:000272711300005 article-title: Responsive magnetic resonance imaging contrast agents as chemical sensors for metals in biology and medicine publication-title: CHEMICAL SOCIETY REVIEWS doi: 10.1039/b914348n – volume: 114 start-page: 5343 year: 2017 ident: WOS:000401797800033 article-title: H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA doi: 10.1073/pnas.1701976114 – volume: 104 start-page: 10780 year: 2007 ident: WOS:000247641900008 article-title: Water-soluble porphyrins imaging platform for MM zinc sensing publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA – volume: 137 start-page: 10216 year: 2015 ident: WOS:000359962000041 article-title: A Bright Fluorescent Probe for H2S Enables Analyte-Responsive, 3D Imaging in Live Zebrafish Using Light Sheet Fluorescence Microscopy publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/jacs.5b04196 – volume: 56 start-page: 16611 year: 2017 ident: WOS:000418359400035 article-title: A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION doi: 10.1002/anie.201710688 – volume: 10 start-page: 26964 year: 2018 ident: WOS:000442460400017 article-title: Highly Stable and NIR Luminescent Ru-LPMSN Hybrid Materials for Sensitive Detection of Cu2+ in Vivo publication-title: ACS APPLIED MATERIALS & INTERFACES doi: 10.1021/acsami.8b08887 – volume: 28 start-page: ARTN 1704689 year: 2018 ident: WOS:000424152900006 article-title: Malonitrile-Functionalized Tetraphenylpyrazine: Aggregation-Induced Emission, Ratiometric Detection of Hydrogen Sulfide, and Mechanochromism publication-title: ADVANCED FUNCTIONAL MATERIALS doi: 10.1002/adfm.201704689 – volume: 44 start-page: 4517 year: 2015 ident: WOS:000357691200005 article-title: Photoluminescence imaging of Zn2+ in living systems publication-title: CHEMICAL SOCIETY REVIEWS doi: 10.1039/c5cs00005j – volume: 7 start-page: 4110 year: 2016 ident: WOS:000378715000019 article-title: Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imaging publication-title: CHEMICAL SCIENCE doi: 10.1039/c5sc04986e – volume: 109 start-page: 8801 year: 2012 ident: WOS:000304991100016 article-title: Shared signaling pathways among gasotransmitters publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA doi: 10.1073/pnas.1206646109 – volume: 8 start-page: 2776 year: 2017 ident: WOS:000397560500034 article-title: A new H2S-specific near-infrared fluorescence-enhanced probe that can visualize the H2S level in colorectal cancer cells in mice publication-title: CHEMICAL SCIENCE doi: 10.1039/c6sc05646f – volume: 335 start-page: 1458 year: 2012 ident: WOS:000301837000036 article-title: Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs publication-title: SCIENCE doi: 10.1126/science.1216210 – volume: 199 start-page: 117 year: 2018 ident: WOS:000432767100015 article-title: Two colorimetric and ratiometric fluorescence probes for hydrogen sulfide based on AIE strategy of alpha-cyanostilbenes publication-title: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY doi: 10.1016/j.saa.2018.03.052 – volume: 44 start-page: 4596 year: 2015 ident: WOS:000357691200008 article-title: Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems publication-title: CHEMICAL SOCIETY REVIEWS doi: 10.1039/c4cs00298a – volume: 7 start-page: 6309 year: 2016 ident: WOS:000384311700002 article-title: Design principles of spectroscopic probes for biological applications publication-title: CHEMICAL SCIENCE doi: 10.1039/c6sc02500e – volume: 11 start-page: 744 year: 2015 ident: WOS:000361536500001 article-title: Searching for harmony in transition-metal signaling publication-title: NATURE CHEMICAL BIOLOGY doi: 10.1038/nchembio.1913 – volume: 41 start-page: 533 year: 2014 ident: WOS:000340546400001 article-title: Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets publication-title: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY doi: 10.1111/1440-1681.12238 – volume: 137 start-page: 8490 year: 2015 ident: WOS:000357964400034 article-title: Forster Resonance Energy Transfer Switchable Self-Assembled Micellar Nanoprobe: Ratiometric Fluorescent Trapping of Endogenous H2S Generation via Fluvastatin-Stimulated Upregulation publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/jacs.5b03248 – volume: 47 start-page: 2873 year: 2018 ident: WOS:000430708600012 article-title: Ratiometric optical nanoprobes enable accurate molecular detection and imaging publication-title: CHEMICAL SOCIETY REVIEWS doi: 10.1039/c7cs00612h – volume: 322 start-page: 587 year: 2008 ident: WOS:000260299100043 article-title: H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase publication-title: SCIENCE doi: 10.1126/science.1162667 – volume: 52 start-page: 1688 year: 2013 ident: WOS:000314650600011 article-title: A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION doi: 10.1002/anie.201207701 – volume: 19 start-page: 316 year: 2001 ident: WOS:000167940700017 article-title: A clearer vision for in vivo imaging publication-title: NATURE BIOTECHNOLOGY – volume: 39 start-page: 31 year: 2019 ident: WOS:000455226200003 article-title: Dopamine: Functions, Signaling, and Association with Neurological Diseases publication-title: CELLULAR AND MOLECULAR NEUROBIOLOGY doi: 10.1007/s10571-018-0632-3 – volume: 6 start-page: 917 year: 2007 ident: WOS:000250536300017 article-title: Hydrogen sulphide and its therapeutic potential publication-title: NATURE REVIEWS DRUG DISCOVERY doi: 10.1038/nrd2425 – volume: 29 start-page: ARTN 1606857 year: 2017 ident: WOS:000403280600014 article-title: Cancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodality Imaging and Therapy publication-title: ADVANCED MATERIALS doi: 10.1002/adma.201606857 – volume: 44 start-page: 4185 year: 2015 ident: WOS:000356610100003 article-title: Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules publication-title: CHEMICAL SOCIETY REVIEWS doi: 10.1039/c4cs00280f – volume: 23 start-page: 254 year: 2017 ident: WOS:000393618700006 article-title: Preparation of an F-18-Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species publication-title: CHEMISTRY-A EUROPEAN JOURNAL doi: 10.1002/chem.201604473 |
| SSID | ssj0004281 |
| Score | 2.6405334 |
| Snippet | Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and... Tracking signaling H₂S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and... |
| Source | Web of Science |
| SourceID | proquest webofscience acs |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 17973 |
| SubjectTerms | Chemistry Chemistry, Multidisciplinary fluorescence hydrogen sulfide image analysis intravenous injection liver mice Physical Sciences S-adenosylmethionine Science & Technology |
| Title | An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice |
| URI | http://dx.doi.org/10.1021/jacs.9b09181 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000498281600004 https://www.proquest.com/docview/2310301481 https://www.proquest.com/docview/2335130946 |
| Volume | 141 |
| WOS | 000498281600004 |
| WOSCitedRecordID | wos000498281600004 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1dT8IwFG2MPuiL30b8Sk14HbJ2H51vZIpoghIBw9vSrW0kykZgGOOv97aMoGiU16VLtnu73nPWnnsQKtuMM6iS1FKkmlhQ8VyLK-lZlCaO1HNKGPlY895rdJ27ntubH5Bd3MEnuj9QMq4EMdQ1rbBeIx7zNcmqhe25_pEwewZzfebR4oD74t26ACXjb1Dyl2JjCkt9C93M5DnT8yQvlUkeV5KPn90a_3nmbbRZYEtcm06GHbQi0120Hs4s3fZQXkvxw9D8vb5oPWd5BsuhcfPCVxP-ajUzYVA5bmmN0CV-1FkbaMutBAN_lu_4qf-W4duBcTbCAHdxO-8PtAGYFLhB2rg7HE297SHbcAtuwjK0jzr1607YsArbBYtTUs0tIYDTxcC4GUuESnzCY6KUV2VOwFxHcBrEirm-dGxOGdMSJAJEjilBXaGA8x6g1TRL5SHCQJWUBxABYJCCBTkI_Jj7yg-4LSmLBS-hcwhUVHw148hsiBMgJPpqET4YM0tXBNHS2xk8lRCciBiLNKBzf46hLlTpwPFKqPw119Fw2swjMhwJaKftGbpUQvYyw8KigbpuHJAfLfEax2gDoFagVYw2PUGr-WgiTwHO5PGZmcuf8aLtrA |
| linkProvider | American Chemical Society |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3JTsMwELVQOcCFHVFWI3FNaewsDreqUIUlBdEW9RY5sS0QNKloihBfz9hNKSCEerXsyJlxPO_FnnkIndiMM4iS1FKknloQ8VyLK-lZlKaO1GtKmPSxqO2FPeeq7_bLZHWdCwOTGMGTRuYQf1ZdQJcJgsYggfCmE60XAYcQzbUazc4sDZIwe4p2febR8p7779E6DqWjH4jyj5hj4ktrFbW_ZmaulTzXxkVSSz9-FW2ce-praKVEmrgxWRrraEFmG2ipORV420RFI8O3Q_Mv-_TuMS9y2ByNthc-H_MXK8qFwej4TmcMneF77cOBFuBKMbBp-Y4fnt5yfDkwOkcYwC_uFE8DLQcmBQ5JB_eGrxOle_A9DMERbEpbqNu66DZDqxRhsDgl9cISAhheAvybsVSo1Cc8IUp5deYEzHUEp0GimOtLx-aUMZ2QRIDWMSWoKxQw4G1UyfJM7iAMxEl5ABgAFCnYnoPAT7iv_IDbkrJE8Co6BkPF5Tc0is3xOAF6oltL80GfqddisJY-3OCZBOPExAimAbn7tw91IWYHjldFJ99dHg8npT1iw5iAhNqeIU9VZM_TrVmWU9dlBIrdOV7jCC2F3egmvrlsX--hZQBhgc5vtOk-qhSvY3kAQKdIDs3y_gQFxPYN |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3JTsMwEB0hkIALO6KsRuIaaOwsDreqUJWlUFFA3CIntkUFTSqaIsTXM3ZTNiEE18SOHHvieS_jmQew53LB0UsyR9Nq6qDH8x2hVeAwlnrK2JS06WOti6B5453e-XcT4I5zYXAQA3zSwAbxzVfdl7qsMGBKBeGNKEEXZ5Ktp0zEzvCtWr3zkQpJuTtGvCEPWHnW_Xtv44vSwRdU-YPfsT6mMQ9X76OzR0se9odFsp--fivc-K_hL8BciThJbWQiizChsiWYqY-F3pahqGXksm__aR-07_Mix03SanyRo6F4dFq5tFidtE3m0CG5MmvZM0JcKUFWrV7Ibfc5Jyc9q3dEEASTTtHtGVkwJUmTdshN_2mkeI82gF1ICzenFbhuHF_Xm04pxuAIRquFIyUyvQR5OOep1GlIRUK1Dqrci7jvScGiRHM_VJ4rGOcmMYkiveNaMl9qZMKrMJnlmVoDggRKBwgcEBxp3KajKExEqMNIuIrxRIoK7OJExeW3NIhtmJwiTTFXy-nDNuOVi3G2TJBDZAonJ6ZWOA1J3q9tmI--O_KCCux9Xva4PyrxEVvmhGTUDSyJqoD7l2b1sqy6KSdQrP_hNXZgun3UiM9PLs42YBaxWGTSHF22CZPF01BtId4pkm1r4W8XKviQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+Optical%2FPhotoacoustic+Dual-Modality+Probe%3A+Ratiometric+in%2Fex+Vivo+Imaging+for+Stimulated+H2S+Upregulation+in+Mice&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.au=Chen%2C+Zhongyan&rft.au=Mu%2C+Xueling&rft.au=Han%2C+Zhong&rft.au=Yang%2C+Shiping&rft.date=2019-11-13&rft.pub=Amer+Chemical+Soc&rft.issn=0002-7863&rft.eissn=1520-5126&rft.volume=141&rft.issue=45&rft.spage=17973&rft.epage=17977&rft_id=info:doi/10.1021%2Fjacs.9b09181&rft_id=info%3Apmid%2F31657918&rft.externalDBID=n%2Fa&rft.externalDocID=000498281600004 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-7863&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-7863&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-7863&client=summon |