Integrating genome-scale metabolic models into the prediction of microbial kinetics in natural environments

• Published in: Geochimica et cosmochimica acta Vol. 242; pp. 102 - 122
• Main Authors: Shapiro, Benjamin, Hoehler, Tori M., Jin, Qusheng
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2018
• Subjects: Biogeochemical reaction modeling; Flux balance analysis; Genome-scale metabolic model; Methanogenesis; Microbial kinetics; Nutrient limitation; Biogeochemical reaction modeling; Flux balance analysis; Genome-scale metabolic model; Nutrient limitation; Microbial kinetics; Methanogenesis

We propose a new method to predict microbial metabolic rates in natural environments using genome-scale metabolic models. This method is a hybrid of existing approaches, i.e., rate laws and flux balance analysis (FBA). It accounts for the availabilities of chemical energy and growth nutrients in the...