Sprayable Hydrogel for pH-Responsive Nanozyme-Derived Bacteria-Infected Wound Healing

• Published in: ACS applied materials & interfaces Vol. 17; no. 4; pp. 5921 - 5932
• Main Authors: Chao, Furong, Cao, Chengliang, Xu, Yin, Gu, Yunjie, Qu, Xinyu, Wang, Qian, Qu, Lu−Lu, Guo, Yuxin, Dong, Xiaochen
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 29.01.2025
• Subjects: adsorption; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; bacterial infections; Biological and Medical Applications of Materials and Interfaces; catalytic activity; chitosan; Chitosan - analogs & derivatives; Chitosan - chemistry; Chitosan - pharmacology; collagen; drug resistance; fibroblasts; glucose; Gold - chemistry; Humans; hyaluronic acid; Hyaluronic Acid - chemistry; hydrogels; Hydrogels - chemistry; Hydrogels - pharmacology; Hydrogen-Ion Concentration; inflammation; Metal Nanoparticles - chemistry; methicillin-resistant Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus - drug effects; Mice; nitrides; Staphylococcal Infections - drug therapy; Staphylococcus aureus - drug effects; Wound Healing - drug effects; wound healing; antibacterial; nanozyme; sprayable hydrogel; cascade reaction

Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads to bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative to antimicrobial material...