P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd-Catalyzed C–N, C–O, and C–C Cross-Coupling Reactions

• Published in: Organic letters Vol. 17; no. 13; pp. 3370 - 3373
• Main Authors: Buitrago Santanilla, Alexander, Christensen, Melodie, Campeau, Louis-Charles, Davies, Ian W, Dreher, Spencer D
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 02.07.2015; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; PALLADIUM PRECATALYSTS; AMINATION; PALLADACYCLE PRECATALYSTS; LIGANDS; BUCHWALD-HARTWIG; ARYL HALIDES; HYDROXYLATION; CHLORIDES; SUZUKI-MIYAURA

The non-nucleophilic organic superbase P2Et phosphazene can enable a broad range of palladium-catalyzed cross-coupling reactions, including C–C, C–N, and C–O couplings of aryl chlorides, bromides, and iodides at room temperature. The mildness and substrate compatibility of this chemistry can deliver...