Design, Synthesis, and Biological Evaluation of Boron-Containing β‑Lactamase Inhibitors: Closed-Loop Education Experiences in an Undergraduate Medicinal Chemistry Course

• Published in: Journal of chemical education Vol. 100; no. 2; pp. 803 - 810
• Main Authors: Liang, Guo-Qing, Deng, Ji, Wu, Cheng-Xu, Li, Wen-Jing, Hu, Yu-Fei, Song, Yu-Qian, Yin, Xiao-Chen, He, Qin, Xiao, You-Cai, Li, Guo-Bo
• Format: Journal Article
• Language: English
• Published: Easton American Chemical Society and Division of Chemical Education, Inc 14.02.2023; American Chemical Society
• Subjects: Academic achievement; Academic Language; Academic writing; Antibiotics; Biological activity; Boron; Chemical synthesis; Chemistry; Closed loops; Design; Design analysis; Education; Educational Experience; Evaluation; Inhibitors; Organic Chemistry; Pharmaceutical sciences; Process management; Scientific Research; Self evaluation; Self Evaluation (Individuals); Skills; Teaching methods; Undergraduate Students; Writing tests; Medicinal Chemistry; Senior Undergraduates; β-Lactamase Inhibitors; Education Mode; Discovery Learning

Medicinal chemistry is an integrated discipline that primarily concerns the design, discovery, synthesis, identification, and interpretation of biologically active compounds at the molecular level. To assist undergraduates in understanding the core subjects of medicinal chemistry, we introduced a cl...