Mechanism for Enhanced Absorption of a Solid Dispersion Formulation of LY2300559 Using the Artificial Stomach Duodenum Model - Polster, Christopher S; Wu, Sy-Juen; Gueorguieva, Ivelina; Sperry, David C (Molecular pharmaceutics, 2015)
Keywords: Acetophenones - chemistry; Acetophenones - pharmacokinetics; Animals; Area Under Curve; Benzoates - chemistry; Benzoates - pharmacokinetics; Biological Availability; Chemistry, Pharmaceutical - methods; Crystallization; Dogs; Drug Design; Duodenum - drug effects; Humans; Hydrogen-Ion Concentration; Intestinal Absorption - drug effects; Madin Darby Canine Kidney Cells; Meglumine - chemistry; Models, Biological; Molecular Structure; Sodium Bicarbonate - chemistry; Solubility; Stomach - drug effects; Tissue Distribution; meglumine; high-shear wet granulation; artificial stomach duodenum; ASD; high-energy solid; amorphous; solid dispersion; bioavailability; pharmacokinetics; supersaturation