Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform

• Published in: Journal of the American Chemical Society Vol. 132; no. 48; pp. 17227 - 17235
• Main Authors: Ryu, Ja-Hyoung, Chacko, Reuben T, Jiwpanich, Siriporn, Bickerton, Sean, Babu, R. Prakash, Thayumanavan, S
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.12.2010
• Subjects: Capsules; Disulfides - chemistry; Doxorubicin - metabolism; Drug Carriers - chemistry; Drug Design; Humans; Hydrophobic and Hydrophilic Interactions; Intracellular Space - metabolism; Kinetics; MCF-7 Cells; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Polyethyleneimine - chemical synthesis; Polyethyleneimine - chemistry

Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, in which the kin...