Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform
Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, in which the kin...
Saved in:
| Published in | Journal of the American Chemical Society Vol. 132; no. 48; pp. 17227 - 17235 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
08.12.2010
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, in which the kinetics of guest molecule release can be fine-tuned by control over cross-linking density. The polymer nanogel precursor is based on a random copolymer that contains oligoethyleneglycol (OEG) and pyridyldisulfide (PDS) units as side-chain functionalities. By introducing variations into the precursor polymer, such as molecular weight and the relative percentages of hydrophilic OEG units and hydrophobic PDS functionalities, we have achieved significant control over nanogel size. We show that the noncovalently encapsulated guest molecules can be released in response to a redox trigger, glutathione (GSH). Stability of dye encapsulation inside the nanogels and tunability in the release of guest molecules have been demonstrated through in vitro fluorescence resonance energy transfer (FRET) experiments. We show in vitro doxorubicin delivery into breast cancer cells (MCF-7) with nanogels of different cross-linking density to demonstrate that it plays a key role in the stable encapsulation of hydrophobic drug molecules and the cell-uptake efficiencies. |
|---|---|
| AbstractList | Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, in which the kinetics of guest molecule release can be fine-tuned by control over cross-linking density. The polymer nanogel precursor is based on a random copolymer that contains oligoethyleneglycol (OEG) and pyridyldisulfide (PDS) units as side-chain functionalities. By introducing variations into the precursor polymer, such as molecular weight and the relative percentages of hydrophilic OEG units and hydrophobic PDS functionalities, we have achieved significant control over nanogel size. We show that the noncovalently encapsulated guest molecules can be released in response to a redox trigger, glutathione (GSH). Stability of dye encapsulation inside the nanogels and tunability in the release of guest molecules have been demonstrated through in vitro fluorescence resonance energy transfer (FRET) experiments. We show in vitro doxorubicin delivery into breast cancer cells (MCF-7) with nanogels of different cross-linking density to demonstrate that it plays a key role in the stable encapsulation of hydrophobic drug molecules and the cell-uptake efficiencies.Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, in which the kinetics of guest molecule release can be fine-tuned by control over cross-linking density. The polymer nanogel precursor is based on a random copolymer that contains oligoethyleneglycol (OEG) and pyridyldisulfide (PDS) units as side-chain functionalities. By introducing variations into the precursor polymer, such as molecular weight and the relative percentages of hydrophilic OEG units and hydrophobic PDS functionalities, we have achieved significant control over nanogel size. We show that the noncovalently encapsulated guest molecules can be released in response to a redox trigger, glutathione (GSH). Stability of dye encapsulation inside the nanogels and tunability in the release of guest molecules have been demonstrated through in vitro fluorescence resonance energy transfer (FRET) experiments. We show in vitro doxorubicin delivery into breast cancer cells (MCF-7) with nanogels of different cross-linking density to demonstrate that it plays a key role in the stable encapsulation of hydrophobic drug molecules and the cell-uptake efficiencies. Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, in which the kinetics of guest molecule release can be fine-tuned by control over cross-linking density. The polymer nanogel precursor is based on a random copolymer that contains oligoethyleneglycol (OEG) and pyridyldisulfide (PDS) units as side-chain functionalities. By introducing variations into the precursor polymer, such as molecular weight and the relative percentages of hydrophilic OEG units and hydrophobic PDS functionalities, we have achieved significant control over nanogel size. We show that the noncovalently encapsulated guest molecules can be released in response to a redox trigger, glutathione (GSH). Stability of dye encapsulation inside the nanogels and tunability in the release of guest molecules have been demonstrated through in vitro fluorescence resonance energy transfer (FRET) experiments. We show in vitro doxorubicin delivery into breast cancer cells (MCF-7) with nanogels of different cross-linking density to demonstrate that it plays a key role in the stable encapsulation of hydrophobic drug molecules and the cell-uptake efficiencies. |
| Author | Chacko, Reuben T Jiwpanich, Siriporn Thayumanavan, S Ryu, Ja-Hyoung Babu, R. Prakash Bickerton, Sean |
| Author_xml | – sequence: 1 givenname: Ja-Hyoung surname: Ryu fullname: Ryu, Ja-Hyoung – sequence: 2 givenname: Reuben T surname: Chacko fullname: Chacko, Reuben T – sequence: 3 givenname: Siriporn surname: Jiwpanich fullname: Jiwpanich, Siriporn – sequence: 4 givenname: Sean surname: Bickerton fullname: Bickerton, Sean – sequence: 5 givenname: R. Prakash surname: Babu fullname: Babu, R. Prakash – sequence: 6 givenname: S surname: Thayumanavan fullname: Thayumanavan, S email: thai@chem.umass.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21077674$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkMtOwzAQRS1URFtgwQ-gbJBgEWrHie2wq1peUgVFPLaW60yqFCcudoLUvyelLQvU1eiOzoxmTh91KlsBQmcEXxMckcFCEczSlEYHqEeSCIcJiVgH9TDGUcgFo13U937RxjgS5Ah1I4I5ZzzuoZdXMHk4ctb7cFJUn5AFU2tWJbjgSVV2DsbfBMPgA5xXdWHgt-u1XRY6GLtmHozBFN_gVsHUqDq3rjxBh7kyHk639Ri9392-jR7CyfP942g4CRUlSR3mAgjXion2FJ1ASiHLRKxzxRjPEk4V5ZQxkc0UJxyI0Eks0jbETBEQeUqP0eVm79LZrwZ8LcvCazBGVWAbLwklKYsSnKzR8y3azErI5NIVpXIrudPQAoMNoNciHORSF3X7r61qpwojCZZr0fJPdDtx9W9it3Qfe7FhlfZyYRtXtV72cD9GRIeI |
| CitedBy_id | crossref_primary_10_1021_acs_analchem_2c00409 crossref_primary_10_1002_marc_201100127 crossref_primary_10_1021_acsami_6b05567 crossref_primary_10_1002_marc_201300818 crossref_primary_10_1002_pola_26335 crossref_primary_10_1021_acs_analchem_2c00648 crossref_primary_10_1021_acs_macromol_4c01086 crossref_primary_10_1021_bc500074a crossref_primary_10_1038_s41428_018_0042_x crossref_primary_10_1021_acs_molpharmaceut_7b01011 crossref_primary_10_1021_ma302499a crossref_primary_10_1021_ma400213j crossref_primary_10_1039_D3PY00641G crossref_primary_10_1021_acs_macromol_9b02595 crossref_primary_10_1039_c1sm05537b crossref_primary_10_1039_C4RA05661B crossref_primary_10_1039_C8PY01577E crossref_primary_10_1039_D3BM00491K crossref_primary_10_2174_2468187311666210301112644 crossref_primary_10_1021_acs_biomac_0c00442 crossref_primary_10_1016_j_colsurfb_2016_01_051 crossref_primary_10_1088_0957_4484_26_39_395602 crossref_primary_10_1002_pol_20240163 crossref_primary_10_1002_pola_28882 crossref_primary_10_1016_j_jconrel_2018_06_010 crossref_primary_10_1002_marc_201500388 crossref_primary_10_1016_S1872_2067_23_64481_X crossref_primary_10_1021_acs_molpharmaceut_7b00284 crossref_primary_10_1002_pola_28766 crossref_primary_10_1021_acs_macromol_3c02633 crossref_primary_10_3390_ph13030044 crossref_primary_10_1039_C2PY20727C crossref_primary_10_1039_C2PY20606D crossref_primary_10_1021_acs_jpcb_7b06165 crossref_primary_10_1021_ma400129e crossref_primary_10_1016_j_biomaterials_2016_06_005 crossref_primary_10_1038_srep46540 crossref_primary_10_1039_C8RA08903E crossref_primary_10_1039_C3PY00852E crossref_primary_10_1002_slct_202300859 crossref_primary_10_1021_acsami_1c04081 crossref_primary_10_1016_j_jcis_2018_04_084 crossref_primary_10_1016_j_polymer_2015_01_024 crossref_primary_10_1007_s40843_024_3048_0 crossref_primary_10_1016_j_progpolymsci_2016_09_003 crossref_primary_10_1016_j_eurpolymj_2015_01_043 crossref_primary_10_1021_bm4004805 crossref_primary_10_1002_cbic_202300149 crossref_primary_10_1016_j_ijpharm_2018_07_060 crossref_primary_10_1039_D4NR01423E crossref_primary_10_1002_marc_201700737 crossref_primary_10_1002_ange_201803847 crossref_primary_10_1016_j_msec_2014_05_050 crossref_primary_10_1021_ma502242v crossref_primary_10_1016_j_actbio_2015_10_037 crossref_primary_10_1021_acs_biomac_6b01576 crossref_primary_10_1016_j_ccr_2021_214368 crossref_primary_10_3390_molecules18033339 crossref_primary_10_1039_C1PY00384D crossref_primary_10_1002_anie_202209227 crossref_primary_10_1002_pola_27216 crossref_primary_10_1021_acs_langmuir_6b01549 crossref_primary_10_1002_chem_201103584 crossref_primary_10_1007_s11706_015_0283_y crossref_primary_10_1007_s13530_014_0211_z crossref_primary_10_1039_C7RA07568E crossref_primary_10_1021_acs_biomac_8b00589 crossref_primary_10_1002_ange_202210623 crossref_primary_10_1039_C8CP02026D crossref_primary_10_1002_anie_201803847 crossref_primary_10_1021_acs_chemrev_0c01282 crossref_primary_10_1016_j_bioactmat_2020_06_002 crossref_primary_10_1021_bm300201x crossref_primary_10_1039_C7RA06357A crossref_primary_10_1016_j_jddst_2023_105289 crossref_primary_10_1021_acs_biomac_8b01321 crossref_primary_10_1002_marc_201400730 crossref_primary_10_1039_D2RA04123E crossref_primary_10_1002_adfm_201806693 crossref_primary_10_1016_j_polymer_2012_12_029 crossref_primary_10_1021_mz300063g crossref_primary_10_1016_j_talanta_2019_120677 crossref_primary_10_1021_acs_macromol_6b01210 crossref_primary_10_1021_acsapm_0c00622 crossref_primary_10_1088_2057_1976_aa79b6 crossref_primary_10_1021_acs_bioconjchem_7b00078 crossref_primary_10_1016_j_ijpharm_2019_118637 crossref_primary_10_3390_ma17215170 crossref_primary_10_1021_ma201085z crossref_primary_10_1021_mp300213g crossref_primary_10_3390_pharmaceutics15020552 crossref_primary_10_1002_mabi_201200122 crossref_primary_10_3390_pharmaceutics14122839 crossref_primary_10_1016_j_jconrel_2018_07_041 crossref_primary_10_3390_pharmaceutics10040173 crossref_primary_10_1016_j_eurpolymj_2021_110387 crossref_primary_10_1021_ma3022376 crossref_primary_10_1039_c3sc50899d crossref_primary_10_1039_C6CC03336A crossref_primary_10_1039_c3ra43320j crossref_primary_10_1002_anie_201310249 crossref_primary_10_1039_c3tb21359e crossref_primary_10_1021_jacs_5b04285 crossref_primary_10_1021_mp500499x crossref_primary_10_1039_D1PY00396H crossref_primary_10_1039_C4CC08000A crossref_primary_10_1021_ja500285p crossref_primary_10_1016_j_eurpolymj_2022_111645 crossref_primary_10_1002_nadc_201178182 crossref_primary_10_1016_j_matchemphys_2020_123579 crossref_primary_10_1016_j_actbio_2019_01_060 crossref_primary_10_1039_c2jm30663h crossref_primary_10_1021_bm400846h crossref_primary_10_1021_acs_biomac_1c01295 crossref_primary_10_1039_C3SC52347K crossref_primary_10_1016_j_jconrel_2016_10_032 crossref_primary_10_1021_acs_biomac_4c00605 crossref_primary_10_1021_acsami_3c00166 crossref_primary_10_1016_j_colsurfb_2016_06_021 crossref_primary_10_1021_jp303260f crossref_primary_10_1016_j_polymdegradstab_2014_05_003 crossref_primary_10_1246_cl_121289 crossref_primary_10_1021_bm401749t crossref_primary_10_1016_j_ejpb_2020_10_009 crossref_primary_10_1039_C5PY00995B crossref_primary_10_1039_D0GC00555J crossref_primary_10_1039_C6RA15165E crossref_primary_10_1039_D0PY01215G crossref_primary_10_1016_j_jcis_2013_03_010 crossref_primary_10_1002_slct_201900976 crossref_primary_10_1021_acs_iecr_9b00666 crossref_primary_10_1039_C3PY01277H crossref_primary_10_1002_ijch_201900160 crossref_primary_10_1002_marc_201500421 crossref_primary_10_1002_smll_201907256 crossref_primary_10_1039_D1BM01127H crossref_primary_10_1039_D4CC03515A crossref_primary_10_1016_j_biomaterials_2013_03_035 crossref_primary_10_1002_polb_24754 crossref_primary_10_1016_j_eurpolymj_2019_109391 crossref_primary_10_1039_C8PY01808A crossref_primary_10_3390_molecules24101873 crossref_primary_10_1016_j_apcatb_2022_122019 crossref_primary_10_1016_j_ijpharm_2019_118716 crossref_primary_10_1021_bm401087n crossref_primary_10_1016_j_compositesb_2023_110726 crossref_primary_10_1039_C9PY01675A crossref_primary_10_1080_09205063_2016_1207588 crossref_primary_10_1007_s12272_017_0995_x crossref_primary_10_1021_mz300179r crossref_primary_10_1021_jacs_6b11181 crossref_primary_10_1039_C4PY01750A crossref_primary_10_1016_j_cis_2021_102566 crossref_primary_10_1002_adtp_201900206 crossref_primary_10_2174_0929867326666181224143734 crossref_primary_10_4155_fmc_11_134 crossref_primary_10_1039_C6TB01285J crossref_primary_10_1016_j_polymdegradstab_2024_110791 crossref_primary_10_1002_pola_28260 crossref_primary_10_1016_j_polymer_2015_12_023 crossref_primary_10_1016_j_polymer_2015_03_004 crossref_primary_10_1021_jacsau_1c00261 crossref_primary_10_1039_C2PY20789C crossref_primary_10_1039_c1py00102g crossref_primary_10_1039_C4PY01217H crossref_primary_10_1021_acsami_8b04394 crossref_primary_10_1016_j_chempr_2019_09_001 crossref_primary_10_1016_j_jconrel_2015_11_009 crossref_primary_10_1021_acsbiomaterials_4c00239 crossref_primary_10_1021_bm300646q crossref_primary_10_1039_C7PY01706E crossref_primary_10_1002_anie_202004017 crossref_primary_10_1016_j_drudis_2018_09_019 crossref_primary_10_1021_acs_macromol_5b00559 crossref_primary_10_1002_ange_202209227 crossref_primary_10_1021_mp300144y crossref_primary_10_1002_mabi_201900071 crossref_primary_10_1016_j_progpolymsci_2016_05_005 crossref_primary_10_1021_acsami_8b07450 crossref_primary_10_1002_smtd_201700307 crossref_primary_10_2217_nnm_2018_0007 crossref_primary_10_1080_17415993_2022_2083914 crossref_primary_10_1016_j_biomaterials_2014_04_025 crossref_primary_10_1016_j_nwnano_2025_100094 crossref_primary_10_1039_C9NJ03773J crossref_primary_10_1080_10601325_2022_2132168 crossref_primary_10_1021_bm400206m crossref_primary_10_1002_adfm_201705475 crossref_primary_10_1039_C5NR02672E crossref_primary_10_1039_C8TB02464B crossref_primary_10_1039_C3PY01269G crossref_primary_10_1007_s40242_020_0007_4 crossref_primary_10_1007_s11095_019_2687_3 crossref_primary_10_1021_bm5008508 crossref_primary_10_1007_s11051_017_3897_4 crossref_primary_10_1088_0957_4484_26_2_025103 crossref_primary_10_1016_j_ijbiomac_2019_02_072 crossref_primary_10_1016_j_progpolymsci_2018_09_006 crossref_primary_10_1002_chem_201405040 crossref_primary_10_1039_C4RA06578F crossref_primary_10_1016_j_jcis_2021_09_163 crossref_primary_10_3390_ijms23041943 crossref_primary_10_1016_j_apcatb_2025_125118 crossref_primary_10_1039_C6CP04978H crossref_primary_10_1016_j_apmt_2020_100646 crossref_primary_10_1021_ma400181z crossref_primary_10_1039_C9SM02499A crossref_primary_10_1021_bm501091p crossref_primary_10_1016_j_snb_2018_07_067 crossref_primary_10_1021_acsmacrolett_2c00763 crossref_primary_10_1021_bm4003078 crossref_primary_10_1021_mz200123f crossref_primary_10_1002_pola_29035 crossref_primary_10_1002_smll_201907671 crossref_primary_10_1016_j_carbpol_2018_08_102 crossref_primary_10_1021_acs_biomac_4c00690 crossref_primary_10_1021_ja4108676 crossref_primary_10_1039_C4NR04563G crossref_primary_10_1021_acs_jpcb_8b09441 crossref_primary_10_1016_j_jcis_2012_02_004 crossref_primary_10_1039_c3cs60094g crossref_primary_10_1039_C5PY01557J crossref_primary_10_1002_anie_201505242 crossref_primary_10_1021_acsanm_8b01686 crossref_primary_10_1016_j_addr_2016_06_011 crossref_primary_10_1016_j_biomaterials_2015_10_056 crossref_primary_10_1021_acsmacrolett_6b00898 crossref_primary_10_1016_j_ijpharm_2016_07_037 crossref_primary_10_1039_C6CC00369A crossref_primary_10_1021_acsomega_3c08528 crossref_primary_10_1016_j_nantod_2025_102645 crossref_primary_10_1021_acs_biomac_2c01269 crossref_primary_10_1016_j_microc_2021_106035 crossref_primary_10_1021_acs_jpcb_7b01377 crossref_primary_10_1039_C5CS00209E crossref_primary_10_1021_bm201855m crossref_primary_10_1021_acs_macromol_5b01456 crossref_primary_10_1080_17425247_2021_1828339 crossref_primary_10_1039_c1sm05264k crossref_primary_10_1016_j_progpolymsci_2024_101818 crossref_primary_10_1002_cbic_202000303 crossref_primary_10_1016_j_eurpolymj_2015_04_033 crossref_primary_10_1039_C5NR07348K crossref_primary_10_1016_j_pmatsci_2020_100738 crossref_primary_10_1039_C4TB01231C crossref_primary_10_1002_adhm_201300308 crossref_primary_10_1021_acsami_7b02252 crossref_primary_10_1134_S1061933X13030149 crossref_primary_10_1021_acs_bioconjchem_2c00024 crossref_primary_10_1016_S1872_2067_24_60025_2 crossref_primary_10_1021_acs_molpharmaceut_6b01146 crossref_primary_10_1039_c1sm06149f crossref_primary_10_1021_mz400515s crossref_primary_10_1002_adfm_201402755 crossref_primary_10_1039_C6RA04335F crossref_primary_10_1039_D2PY01291J crossref_primary_10_1002_anie_201611479 crossref_primary_10_1002_adma_201501558 crossref_primary_10_1016_j_jconrel_2015_05_273 crossref_primary_10_1016_j_jpowsour_2017_06_073 crossref_primary_10_1016_j_radphyschem_2017_04_019 crossref_primary_10_1016_j_polymer_2012_08_053 crossref_primary_10_1021_acsabm_9b00941 crossref_primary_10_1002_asia_201403115 crossref_primary_10_1039_C7CC00963A crossref_primary_10_1002_mabi_201700356 crossref_primary_10_1039_C5PY01295C crossref_primary_10_1039_C9PY00057G crossref_primary_10_1039_c1py00360g crossref_primary_10_1002_cctc_202301553 crossref_primary_10_1016_j_cis_2019_01_005 crossref_primary_10_1021_acsami_4c11091 crossref_primary_10_1039_c2cc32408c crossref_primary_10_3390_nano7040077 crossref_primary_10_1039_C7PY01424D crossref_primary_10_1016_j_jconrel_2018_10_033 crossref_primary_10_1021_acs_chemmater_8b03741 crossref_primary_10_1039_c2jm34136k crossref_primary_10_1021_mz300489n crossref_primary_10_1021_la300590t crossref_primary_10_1016_j_jiec_2012_11_025 crossref_primary_10_1002_pola_26922 crossref_primary_10_3390_gels3020016 crossref_primary_10_1039_C6SM02713J crossref_primary_10_1021_acs_bioconjchem_8b00085 crossref_primary_10_1021_mp500329z crossref_primary_10_1016_j_progpolymsci_2023_101765 crossref_primary_10_1021_am301600u crossref_primary_10_1002_macp_201900419 crossref_primary_10_1039_C7TB02239E crossref_primary_10_1039_c2sm25280e crossref_primary_10_1039_C4CS00133H crossref_primary_10_1016_j_eurpolymj_2015_03_033 crossref_primary_10_1021_mz3002287 crossref_primary_10_1002_asia_201301030 crossref_primary_10_1039_c1cc13955j crossref_primary_10_1039_C3PY01652H crossref_primary_10_1021_acs_biomac_4c01368 crossref_primary_10_1016_j_colsurfb_2018_02_052 crossref_primary_10_1039_C5RA05138J crossref_primary_10_1021_ma200691s crossref_primary_10_1039_C8RA06589F crossref_primary_10_1039_C7CP05084D crossref_primary_10_1039_D4NR02494J crossref_primary_10_1002_smll_202401926 crossref_primary_10_1016_j_addr_2012_02_002 crossref_primary_10_1039_C5BM00002E crossref_primary_10_1016_j_ijpharm_2020_119481 crossref_primary_10_1021_jacs_1c08574 crossref_primary_10_1021_acs_biomac_7b01220 crossref_primary_10_1039_c1py00261a crossref_primary_10_1039_C5RA05430C crossref_primary_10_1002_marc_201300072 crossref_primary_10_1021_cr500131f crossref_primary_10_1039_C7NJ02484C crossref_primary_10_1002_polb_24555 crossref_primary_10_1016_j_colsurfb_2024_113790 crossref_primary_10_1039_C3CS60324E crossref_primary_10_1021_acs_macromol_8b01100 crossref_primary_10_1039_C6PY01423B crossref_primary_10_1039_C7RA03579A crossref_primary_10_1021_ma500774g crossref_primary_10_1039_C4CS00341A crossref_primary_10_1016_j_trac_2012_09_018 crossref_primary_10_1021_acs_bioconjchem_2c00094 crossref_primary_10_1039_C8PY01160E crossref_primary_10_1021_ja311374b crossref_primary_10_1021_acs_macromol_5b01110 crossref_primary_10_1007_s13346_024_01684_w crossref_primary_10_1021_acsbiomaterials_6b00310 crossref_primary_10_1038_srep40011 crossref_primary_10_1039_c3py00085k crossref_primary_10_1016_j_colsurfb_2012_05_007 crossref_primary_10_1016_j_polymer_2017_01_019 crossref_primary_10_1016_j_ijpharm_2020_119268 crossref_primary_10_1021_acs_biomac_5b01020 crossref_primary_10_1002_ange_201310249 crossref_primary_10_1039_c1jm10391a crossref_primary_10_1039_C9PY01492F crossref_primary_10_1016_j_colsurfb_2014_08_002 crossref_primary_10_3390_app7111175 crossref_primary_10_1021_acs_nanolett_6b02915 crossref_primary_10_1021_la3020817 crossref_primary_10_1039_C9TB02868D crossref_primary_10_1021_ja501632r crossref_primary_10_1016_j_apsb_2018_01_004 crossref_primary_10_1016_j_snb_2019_04_103 crossref_primary_10_1021_acsomega_0c05535 crossref_primary_10_1016_j_jconrel_2014_08_028 crossref_primary_10_1039_C5RA22679A crossref_primary_10_1002_app_39453 crossref_primary_10_1016_j_ccr_2023_215260 crossref_primary_10_1021_acs_chemrev_0c01088 crossref_primary_10_1021_la3033463 crossref_primary_10_1039_C6QM00135A crossref_primary_10_1021_acs_langmuir_9b00676 crossref_primary_10_1007_s40242_018_8147_5 crossref_primary_10_1002_anie_202210623 crossref_primary_10_1039_C2PY20582C crossref_primary_10_1002_pc_23604 crossref_primary_10_1021_acs_chemrev_1c00197 crossref_primary_10_1021_ma201531w crossref_primary_10_1038_nmat3776 crossref_primary_10_1093_pnasnexus_pgad252 crossref_primary_10_1080_13543776_2016_1178720 crossref_primary_10_1007_s13205_019_1720_x crossref_primary_10_1021_acsami_7b17926 crossref_primary_10_1002_macp_202200058 crossref_primary_10_3390_jfb13040188 crossref_primary_10_1002_smll_201601997 crossref_primary_10_1088_1361_6528_abf300 crossref_primary_10_1039_D0TB01260B crossref_primary_10_1039_D3PY00210A crossref_primary_10_1007_s11051_017_3913_8 crossref_primary_10_1016_j_radphyschem_2013_02_005 crossref_primary_10_1039_D2BM02110B crossref_primary_10_1016_j_jconrel_2019_11_028 crossref_primary_10_1021_ja500634u crossref_primary_10_1021_acs_langmuir_5b01949 crossref_primary_10_1002_marc_201200029 crossref_primary_10_1039_c3sm50374g crossref_primary_10_1039_C9PY01910C crossref_primary_10_1021_la503971q crossref_primary_10_1039_c3cc44200d crossref_primary_10_1039_C3SC52233D crossref_primary_10_1039_c2cc30908d crossref_primary_10_1039_C4CC03688C crossref_primary_10_1021_am500976w crossref_primary_10_1002_marc_201600808 crossref_primary_10_1002_marc_201700478 crossref_primary_10_1002_mabi_201800057 crossref_primary_10_1002_mabi_202300256 crossref_primary_10_1016_j_colsurfb_2017_04_047 crossref_primary_10_1021_acs_macromol_6b01397 crossref_primary_10_1016_j_mattod_2015_11_025 crossref_primary_10_1021_mp3004226 crossref_primary_10_1039_c2py00600f crossref_primary_10_1021_acsami_8b15837 crossref_primary_10_1038_pj_2016_122 crossref_primary_10_1016_j_jcis_2012_09_055 crossref_primary_10_1002_marc_202200421 crossref_primary_10_1002_cbdv_202301009 crossref_primary_10_1039_c2sc20098h crossref_primary_10_1021_acs_biomac_5b01578 crossref_primary_10_1021_acs_langmuir_4c02374 crossref_primary_10_1021_acsmacrolett_7b00709 crossref_primary_10_1002_adtp_201900062 crossref_primary_10_1039_c3cc38761e crossref_primary_10_1039_C6RA21427D crossref_primary_10_1039_C5CS00798D crossref_primary_10_1016_j_jcis_2019_01_049 crossref_primary_10_1021_acsbiomaterials_6b00256 crossref_primary_10_1016_j_biomaterials_2017_04_020 crossref_primary_10_1021_ma202721s crossref_primary_10_1039_C6RA05808F crossref_primary_10_1016_j_lwt_2014_07_054 crossref_primary_10_1039_C3PY01192E crossref_primary_10_1002_ange_201505242 crossref_primary_10_1016_j_eurpolymj_2022_111224 crossref_primary_10_1021_acs_langmuir_5b02865 crossref_primary_10_1002_ange_201611479 crossref_primary_10_1021_ja510147n crossref_primary_10_1002_macp_201400578 crossref_primary_10_1039_C6PY00914J crossref_primary_10_1016_j_jsamd_2019_04_004 crossref_primary_10_1021_ja3019143 crossref_primary_10_1039_C4TB01902D crossref_primary_10_1186_s12951_018_0398_2 crossref_primary_10_1002_adfm_201200780 crossref_primary_10_1021_la4034468 crossref_primary_10_1021_bm301583s crossref_primary_10_1016_j_msec_2017_04_098 crossref_primary_10_1039_C4TB01141D crossref_primary_10_1039_C5SC01225B crossref_primary_10_1021_acs_bioconjchem_2c00493 crossref_primary_10_1021_acs_biomac_5b00589 crossref_primary_10_1002_chem_201705217 crossref_primary_10_1016_j_pmatsci_2023_101167 crossref_primary_10_1039_D3TB01677C crossref_primary_10_1002_ange_202004017 crossref_primary_10_1039_D4TB01429D crossref_primary_10_1021_ma501104s crossref_primary_10_4155_tde_13_105 crossref_primary_10_1007_s10118_018_2080_4 crossref_primary_10_1021_acs_biomac_7b01659 crossref_primary_10_1039_C9SM01960J crossref_primary_10_1002_adma_202109701 crossref_primary_10_1039_C5PY00969C crossref_primary_10_2217_nnm_14_170 crossref_primary_10_1007_s10965_013_0206_5 crossref_primary_10_1039_C9PY00404A crossref_primary_10_1063_1674_0068_cjcp2006090 crossref_primary_10_1021_acsami_8b01114 crossref_primary_10_1021_acsami_3c18140 crossref_primary_10_1021_acs_nanolett_0c02319 crossref_primary_10_1021_acsmacrolett_5b00870 crossref_primary_10_1016_j_pharmthera_2019_02_010 crossref_primary_10_1039_C8BM01093E crossref_primary_10_1002_cpch_85 crossref_primary_10_1021_acs_chemmater_5b00187 crossref_primary_10_1021_acs_chemmater_6b03440 crossref_primary_10_1021_bm200483t crossref_primary_10_1016_j_carbpol_2013_05_009 crossref_primary_10_1002_hlca_201600370 crossref_primary_10_3390_ijms24043307 crossref_primary_10_1002_app_46154 crossref_primary_10_1002_pola_25001 crossref_primary_10_1039_C3PY01502E crossref_primary_10_1039_C7RA10499E crossref_primary_10_1002_biot_201900408 crossref_primary_10_1021_cr300358b crossref_primary_10_1039_C4PY00867G |
| Cites_doi | 10.1038/nrd1088 10.1021/bm070381+ 10.1073/pnas.0607705103 10.1021/ja105059g 10.1016/j.nano.2005.06.004 10.1039/b927215c 10.1021/bm800657e 10.1016/S1359-6446(04)03276-3 10.1002/anie.200301694 10.1002/smll.200900906 10.1021/ja803947s 10.1021/ja065324n 10.1038/nbt1141 10.1016/S0169-409X(02)00015-7 10.1016/S0169-409X(98)00003-9 10.1021/nl902789s 10.2174/1570163054866882 10.1021/ja069150l 10.1016/S0021-9258(18)61118-4 10.1002/anie.200900441 10.1016/0032-3861(76)90208-1 10.1038/nrd2614 10.1021/ja074301l 10.1021/ja900591t 10.1016/j.addr.2005.09.014 10.1002/anie.200904260 10.1002/anie.200805133 10.1517/17425240903289928 10.1021/mp800137z 10.1021/ja026925r 10.1021/ma0604035 10.1038/nrd1632 10.1016/j.jconrel.2008.06.015 10.1016/S0169-409X(00)00124-1 10.1021/ma062493j 10.1016/j.addr.2005.07.002 10.1016/j.jconrel.2005.09.028 10.1002/adma.200802453 10.1016/j.plipres.2004.12.001 10.1016/j.jconrel.2004.02.003 10.1038/nnano.2007.387 10.1021/ja102316a 10.1038/nbt1171 10.1016/S0168-3659(99)00248-5 10.1039/b9nr00112c 10.1002/anie.200901583 10.1016/j.progpolymsci.2008.01.002 10.1016/j.jconrel.2005.09.034 10.1021/bc010102u 10.1021/ma062925q 10.1021/ja809475a 10.1039/B811923F 10.1021/la703570m 10.1073/pnas.0601455103 10.1007/s003960100559 10.1016/j.biomaterials.2008.04.035 10.1021/la900734d 10.1021/ma801782q 10.1242/jcs.115.4.849 10.1038/42218 10.1038/nmat999 10.1002/adma.200802475 10.1016/j.addr.2009.05.006 10.1126/science.1095833 10.1073/pnas.0707046105 10.1021/ma0507286 10.1021/bm800043n 10.1021/ja054542y 10.1021/bc900553n 10.1038/nmat2569 10.1158/0008-5472.CAN-03-0654 10.1021/mp9001206 10.1021/ma021628s 10.1126/science.1078192 10.1038/nrc1958 10.1021/bm800867n 10.1021/ma900288t |
| ContentType | Journal Article |
| Copyright | Copyright © 2010 American Chemical Society |
| Copyright_xml | – notice: Copyright © 2010 American Chemical Society |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1021/ja1069932 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| DocumentTitleAlternate | Self-Cross-Linked Polymer Nanogels |
| EISSN | 1520-5126 |
| EndPage | 17235 |
| ExternalDocumentID | 21077674 10_1021_ja1069932 a387857063 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Journal Article |
| GroupedDBID | - .K2 02 4.4 53G 55A 5GY 5RE 5VS 7~N 85S AABXI ABFLS ABMVS ABPPZ ABPTK ABUCX ABUFD ACGFS ACJ ACNCT ACS AEESW AENEX AETEA AFEFF AFFNX ALMA_UNASSIGNED_HOLDINGS AQSVZ BAANH BKOMP CS3 DU5 DZ EBS ED ED~ EJD ET F5P GNL IH9 JG JG~ K2 LG6 P2P ROL RXW TAE TAF TN5 UHB UI2 UKR UPT VF5 VG9 VQA W1F WH7 X XFK YZZ ZHY --- -DZ -ET -~X .DC AAHBH AAYOK AAYXX ABBLG ABJNI ABLBI ABQRX ACBEA ACGFO ADHLV AGXLV AHDLI AHGAQ CITATION CUPRZ GGK IH2 XSW YQT ZCA ~02 AAYWT CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-a315t-f8e17ca68107c5e93edd84cfa667d573a373668dba717e18c5489ba746a1e8f93 |
| IEDL.DBID | ACS |
| ISSN | 0002-7863 1520-5126 |
| IngestDate | Tue Aug 05 09:52:03 EDT 2025 Mon Jul 21 05:54:38 EDT 2025 Tue Jul 01 04:15:06 EDT 2025 Thu Apr 24 22:50:50 EDT 2025 Thu Aug 27 13:43:02 EDT 2020 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 48 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a315t-f8e17ca68107c5e93edd84cfa667d573a373668dba717e18c5489ba746a1e8f93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 21077674 |
| PQID | 1319625059 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1319625059 pubmed_primary_21077674 crossref_citationtrail_10_1021_ja1069932 crossref_primary_10_1021_ja1069932 acs_journals_10_1021_ja1069932 |
| ProviderPackageCode | JG~ 55A AABXI GNL VF5 7~N ACJ VG9 W1F ACS AEESW AFEFF .K2 ABMVS ABUCX IH9 BAANH AQSVZ ED~ UI2 CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20101208 2010-12-08 2010-Dec-08 |
| PublicationDateYYYYMMDD | 2010-12-08 |
| PublicationDate_xml | – month: 12 year: 2010 text: 20101208 day: 08 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of the American Chemical Society |
| PublicationTitleAlternate | J. Am. Chem. Soc |
| PublicationYear | 2010 |
| Publisher | American Chemical Society |
| Publisher_xml | – name: American Chemical Society |
| References | Oh J. K. (ref1/cit1f) 2008; 33 Eliaz R. E. (ref6/cit6b) 2004; 64 Patri A. K. (ref4/cit4b) 2005; 57 Lutz J.-F. (ref16/cit16b) 2006; 128 Savić R. (ref7/cit7d) 2003; 300 Murthy N. (ref20/cit20a) 2002; 124 Jiang J. (ref20/cit20e) 2007; 40 Wu A. M. (ref22/cit22d) 2005; 23 Moskaug J. O. (ref23/cit23) 1987; 262 Chen H. (ref10/cit10a) 2008; 105 Vo C. D. (ref17/cit17) 2002; 280 MacKay J. A. (ref3/cit3c) 2009; 8 Li Y.-L. (ref22/cit22f) 2009; 48 Bae Y. H. (ref9/cit9) 2008; 131 Andresen T. L. (ref6/cit6c) 2005; 44 Baban D. F. (ref2/cit2b) 1998; 34 Chan Y. (ref20/cit20b) 2008; 9 Duncan R. (ref2/cit2c) 2003; 2 Klaikherd A. (ref18/cit18) 2009; 131 Kim C. K. (ref5/cit5a) 2009; 1 Jeong B. (ref1/cit1j) 1997; 388 Kale T. S. (ref1/cit1d) 2009; 25 You J.-O. (ref24/cit24a) 2009; 9 Beningo K. A. (ref24/cit24b) 2002; 115 Oh J. K. (ref14/cit14b) 2007; 129 Bauhuber S. (ref22/cit22c) 2009; 21 Fox M. E. (ref4/cit4a) 2009; 6 Choi S. K. (ref4/cit4d) 2010 Jiang J. (ref15/cit15b) 2005; 38 Kataoka K. (ref7/cit7c) 2001; 47 Cherian A. E. (ref15/cit15d) 2007; 129 Wang Y.-C. (ref19/cit19) 2009; 42 Xu P. (ref10/cit10c) 2009; 6 Peer D. (ref1/cit1a) 2007; 2 Bachelder E. M. (ref1/cit1h) 2008; 130 Yoo H. S. (ref7/cit7e) 2004; 96 Yang J. (ref21/cit21c) 2006; 103 Agasti S. S. (ref5/cit5b) 2009; 131 Davis M. E. (ref7/cit7b) 2008; 7 Saeki S. (ref16/cit16a) 1976; 17 Sisson A. L. (ref14/cit14a) 2009; 48 West K. R. (ref1/cit1g) 2005; 2 Duncan R. (ref3/cit3a) 2006; 6 Kabanov A. V. (ref13/cit13a) 2009; 48 Torchilin V. P. (ref6/cit6d) 2005; 4 Lavasanifar A. (ref8/cit8a) 2002; 54 Raemdonck K. (ref13/cit13b) 2009; 5 Mackay M. E. (ref15/cit15c) 2003; 2 Kadlubowski S. (ref15/cit15a) 2003; 36 van der Poll D. G. (ref4/cit4c) 2010; 21 Yin H. (ref7/cit7f) 2008; 131 Bae K. H. (ref22/cit22e) 2008; 29 Koo O. M. (ref1/cit1e) 2005; 1 Sivakumar S. (ref21/cit21b) 2009; 21 Gaucher G. (ref8/cit8b) 2005; 109 Allen T. M. (ref1/cit1c) 2004; 303 Lutz J.-F. (ref16/cit16c) 2007; 40 Maeda H. (ref2/cit2a) 2000; 65 Liu S. (ref7/cit7a) 2009; 42 Greco F. (ref3/cit3b) 2009; 61 Bernkop-Schnürch A. (ref21/cit21a) 2005; 57 Jiwpanich S. (ref11/cit11) 2010; 132 Aathimanikandan S. V. (ref16/cit16d) 2005; 127 Miller K. (ref3/cit3e) 2009; 48 Abu Lila A. S. (ref6/cit6a) 2009; 6 Ryu J.-H. (ref12/cit12) 2010; 132 Oh J. K. (ref20/cit20c) 2007; 8 Gillies E. R. (ref2/cit2d) 2005; 10 Ihre H. R. (ref4/cit4e) 2002; 13 Chong S.-F. (ref21/cit21d) 2009; 5 Chen H. (ref10/cit10b) 2008; 24 Lee C. C. (ref1/cit1i) 2005; 23 Kataoka K. (ref8/cit8c) 2001; 47 Jia Z. (ref22/cit22a) 2008; 9 Lee C. C. (ref4/cit4f) 2006; 103 Zhang L. (ref20/cit20d) 2008; 9 Mrkvan T. (ref3/cit3d) 2005; 110 Li Y. (ref22/cit22b) 2006; 39 Haag R. (ref1/cit1b) 2004; 43 |
| References_xml | – volume: 2 start-page: 347 year: 2003 ident: ref2/cit2c publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd1088 – volume: 8 start-page: 3326 year: 2007 ident: ref20/cit20c publication-title: Biomacromolecules doi: 10.1021/bm070381+ – volume: 103 start-page: 16649 year: 2006 ident: ref4/cit4f publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0607705103 – volume: 132 start-page: 10683 year: 2010 ident: ref11/cit11 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja105059g – volume: 1 start-page: 193 year: 2005 ident: ref1/cit1e publication-title: Nanomedicine: NBM doi: 10.1016/j.nano.2005.06.004 – start-page: 2632 year: 2010 ident: ref4/cit4d publication-title: Chem. Commun. doi: 10.1039/b927215c – volume: 9 start-page: 3106 year: 2008 ident: ref22/cit22a publication-title: Biomacromolecules doi: 10.1021/bm800657e – volume: 10 start-page: 35 year: 2005 ident: ref2/cit2d publication-title: Drug Discovery Today doi: 10.1016/S1359-6446(04)03276-3 – volume: 43 start-page: 278 year: 2004 ident: ref1/cit1b publication-title: Angew. Chem., Int. Ed. doi: 10.1002/anie.200301694 – volume: 5 start-page: 2601 year: 2009 ident: ref21/cit21d publication-title: Small doi: 10.1002/smll.200900906 – volume: 130 start-page: 10494 year: 2008 ident: ref1/cit1h publication-title: J. Am. Chem. Soc. doi: 10.1021/ja803947s – volume: 128 start-page: 13046 year: 2006 ident: ref16/cit16b publication-title: J. Am. Chem. Soc. doi: 10.1021/ja065324n – volume: 23 start-page: 1137 year: 2005 ident: ref22/cit22d publication-title: Nat. Biotechnol. doi: 10.1038/nbt1141 – volume: 54 start-page: 169 year: 2002 ident: ref8/cit8a publication-title: Adv. Drug Delivery Rev. doi: 10.1016/S0169-409X(02)00015-7 – volume: 34 start-page: 109 year: 1998 ident: ref2/cit2b publication-title: Adv. Drug Delivery Rev. doi: 10.1016/S0169-409X(98)00003-9 – volume: 9 start-page: 4467 year: 2009 ident: ref24/cit24a publication-title: Nano Lett. doi: 10.1021/nl902789s – volume: 2 start-page: 123 year: 2005 ident: ref1/cit1g publication-title: Curr. Drug Discovery Technol. doi: 10.2174/1570163054866882 – volume: 129 start-page: 5939 year: 2007 ident: ref14/cit14b publication-title: J. Am. Chem. Soc. doi: 10.1021/ja069150l – volume: 262 start-page: 10339 year: 1987 ident: ref23/cit23 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)61118-4 – volume: 48 start-page: 5418 year: 2009 ident: ref13/cit13a publication-title: Angew. Chem., Int. Ed. doi: 10.1002/anie.200900441 – volume: 17 start-page: 685 year: 1976 ident: ref16/cit16a publication-title: Polymer doi: 10.1016/0032-3861(76)90208-1 – volume: 7 start-page: 771 year: 2008 ident: ref7/cit7b publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd2614 – volume: 129 start-page: 11350 year: 2007 ident: ref15/cit15d publication-title: J. Am. Chem. Soc. doi: 10.1021/ja074301l – volume: 131 start-page: 5728 year: 2009 ident: ref5/cit5b publication-title: J. Am. Chem. Soc. doi: 10.1021/ja900591t – volume: 57 start-page: 2203 year: 2005 ident: ref4/cit4b publication-title: Adv. Drug Delivery Rev. doi: 10.1016/j.addr.2005.09.014 – volume: 48 start-page: 9914 year: 2009 ident: ref22/cit22f publication-title: Angew. Chem., Int. Ed. doi: 10.1002/anie.200904260 – volume: 48 start-page: 2949 year: 2009 ident: ref3/cit3e publication-title: Angew. Chem., Int. Ed. doi: 10.1002/anie.200805133 – volume: 6 start-page: 1297 year: 2009 ident: ref6/cit6a publication-title: Expert Opin. Drug Delivery doi: 10.1517/17425240903289928 – volume: 6 start-page: 190 year: 2009 ident: ref10/cit10c publication-title: Mol. Pharmaceutics doi: 10.1021/mp800137z – volume: 124 start-page: 12398 year: 2002 ident: ref20/cit20a publication-title: J. Am. Chem. Soc. doi: 10.1021/ja026925r – volume: 39 start-page: 2726 year: 2006 ident: ref22/cit22b publication-title: Macromolecules doi: 10.1021/ma0604035 – volume: 4 start-page: 145 year: 2005 ident: ref6/cit6d publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd1632 – volume: 131 start-page: 2 year: 2008 ident: ref7/cit7f publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2008.06.015 – volume: 47 start-page: 113 year: 2001 ident: ref7/cit7c publication-title: Adv. Drug Delivery Rev. doi: 10.1016/S0169-409X(00)00124-1 – volume: 40 start-page: 790 year: 2007 ident: ref20/cit20e publication-title: Macromolecules doi: 10.1021/ma062493j – volume: 57 start-page: 1569 year: 2005 ident: ref21/cit21a publication-title: Adv. Drug Delivery Rev. doi: 10.1016/j.addr.2005.07.002 – volume: 110 start-page: 119 year: 2005 ident: ref3/cit3d publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2005.09.028 – volume: 21 start-page: 3286 year: 2009 ident: ref22/cit22c publication-title: Adv. Mater. doi: 10.1002/adma.200802453 – volume: 44 start-page: 68 year: 2005 ident: ref6/cit6c publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2004.12.001 – volume: 96 start-page: 273 year: 2004 ident: ref7/cit7e publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2004.02.003 – volume: 2 start-page: 751 year: 2007 ident: ref1/cit1a publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2007.387 – volume: 132 start-page: 8246 year: 2010 ident: ref12/cit12 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja102316a – volume: 23 start-page: 1517 year: 2005 ident: ref1/cit1i publication-title: Nat. Biotechnol. doi: 10.1038/nbt1171 – volume: 65 start-page: 271 year: 2000 ident: ref2/cit2a publication-title: J. Controlled Release doi: 10.1016/S0168-3659(99)00248-5 – volume: 1 start-page: 61 year: 2009 ident: ref5/cit5a publication-title: Nanoscale doi: 10.1039/b9nr00112c – volume: 48 start-page: 7540 year: 2009 ident: ref14/cit14a publication-title: Angew. Chem., Int. Ed. doi: 10.1002/anie.200901583 – volume: 33 start-page: 448 year: 2008 ident: ref1/cit1f publication-title: Prog. Polym. Sci. doi: 10.1016/j.progpolymsci.2008.01.002 – volume: 109 start-page: 169 year: 2005 ident: ref8/cit8b publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2005.09.034 – volume: 13 start-page: 443 year: 2002 ident: ref4/cit4e publication-title: Bioconjugate Chem. doi: 10.1021/bc010102u – volume: 40 start-page: 2503 year: 2007 ident: ref16/cit16c publication-title: Macromolecules doi: 10.1021/ma062925q – volume: 131 start-page: 4830 year: 2009 ident: ref18/cit18 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja809475a – volume: 5 start-page: 707 year: 2009 ident: ref13/cit13b publication-title: Soft Matter doi: 10.1039/B811923F – volume: 24 start-page: 5213 year: 2008 ident: ref10/cit10b publication-title: Langmuir doi: 10.1021/la703570m – volume: 131 start-page: 2 year: 2008 ident: ref9/cit9 publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2008.06.015 – volume: 103 start-page: 13872 year: 2006 ident: ref21/cit21c publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0601455103 – volume: 47 start-page: 113 year: 2001 ident: ref8/cit8c publication-title: Adv. Drug Delivery Rev. doi: 10.1016/S0169-409X(00)00124-1 – volume: 280 start-page: 400 year: 2002 ident: ref17/cit17 publication-title: Colloid Polym. Sci. doi: 10.1007/s003960100559 – volume: 29 start-page: 3376 year: 2008 ident: ref22/cit22e publication-title: Biomaterials doi: 10.1016/j.biomaterials.2008.04.035 – volume: 25 start-page: 9660 year: 2009 ident: ref1/cit1d publication-title: Langmuir doi: 10.1021/la900734d – volume: 42 start-page: 3 year: 2009 ident: ref7/cit7a publication-title: Macromolecules doi: 10.1021/ma801782q – volume: 115 start-page: 849 year: 2002 ident: ref24/cit24b publication-title: J. Cell Sci. doi: 10.1242/jcs.115.4.849 – volume: 388 start-page: 860 year: 1997 ident: ref1/cit1j publication-title: Nature doi: 10.1038/42218 – volume: 2 start-page: 762 year: 2003 ident: ref15/cit15c publication-title: Nat. Mater. doi: 10.1038/nmat999 – volume: 21 start-page: 1820 year: 2009 ident: ref21/cit21b publication-title: Adv. Mater. doi: 10.1002/adma.200802475 – volume: 61 start-page: 1203 year: 2009 ident: ref3/cit3b publication-title: Adv. Drug Delivery Rev. doi: 10.1016/j.addr.2009.05.006 – volume: 303 start-page: 1818 year: 2004 ident: ref1/cit1c publication-title: Science doi: 10.1126/science.1095833 – volume: 105 start-page: 6596 year: 2008 ident: ref10/cit10a publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0707046105 – volume: 38 start-page: 5886 year: 2005 ident: ref15/cit15b publication-title: Macromolecules doi: 10.1021/ma0507286 – volume: 9 start-page: 1826 year: 2008 ident: ref20/cit20b publication-title: Biomacromolecules doi: 10.1021/bm800043n – volume: 127 start-page: 14922 year: 2005 ident: ref16/cit16d publication-title: J. Am. Chem. Soc. doi: 10.1021/ja054542y – volume: 21 start-page: 764 year: 2010 ident: ref4/cit4c publication-title: Bioconjugate Chem. doi: 10.1021/bc900553n – volume: 8 start-page: 993 year: 2009 ident: ref3/cit3c publication-title: Nat. Mater. doi: 10.1038/nmat2569 – volume: 64 start-page: 711 year: 2004 ident: ref6/cit6b publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-03-0654 – volume: 6 start-page: 1562 year: 2009 ident: ref4/cit4a publication-title: Mol. Pharmaceutics doi: 10.1021/mp9001206 – volume: 36 start-page: 2484 year: 2003 ident: ref15/cit15a publication-title: Macromolecules doi: 10.1021/ma021628s – volume: 300 start-page: 615 year: 2003 ident: ref7/cit7d publication-title: Science doi: 10.1126/science.1078192 – volume: 6 start-page: 688 year: 2006 ident: ref3/cit3a publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1958 – volume: 9 start-page: 3321 year: 2008 ident: ref20/cit20d publication-title: Biomacromolecules doi: 10.1021/bm800867n – volume: 42 start-page: 3026 year: 2009 ident: ref19/cit19 publication-title: Macromolecules doi: 10.1021/ma900288t |
| SSID | ssj0004281 |
| Score | 2.5349715 |
| Snippet | Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in... |
| SourceID | proquest pubmed crossref acs |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 17227 |
| SubjectTerms | Capsules Disulfides - chemistry Doxorubicin - metabolism Drug Carriers - chemistry Drug Design Humans Hydrophobic and Hydrophilic Interactions Intracellular Space - metabolism Kinetics MCF-7 Cells Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polyethyleneimine - chemical synthesis Polyethyleneimine - chemistry |
| Title | Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform |
| URI | http://dx.doi.org/10.1021/ja1069932 https://www.ncbi.nlm.nih.gov/pubmed/21077674 https://www.proquest.com/docview/1319625059 |
| Volume | 132 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV07T8MwELaqMsDC-1FeMo-BJRWJk9hhq1qqigEVlUrdIsc5V4iQoDYdyq_nnDYFRAtjIic5-Wzf98Xn7wi5xpAUOYETW6aKDxIUj1mSg0Qgx4WUWkqQRZbvo9_puw8Db1AhVyt28B2jD4SsBaMorrNrjo-T1-CfZu_r8KMj7BLjcuGzUj7o-6Mm9Kjxz9CzAk8WcaW9RVrl6ZxZOslrfZJHdfXxW6zxL5O3yeYcV9LGbCDskAqku2S9WZZz2yNPPUi01TSWWYaAQky7WTJ9gxHFFTYbYoy8ow1q_p-hsxIo7pozKy-KtkaTIW1BYnI4prSbyNxA3X3Sb98_NzvWvJ6CJZnt5ZYWYHMljQIZVx4EDOJYuEpL3-exx5lknPm-iCOJHA9soZDNBHjh-tIGoQN2QKpplsIRoTYgrowRHTCuXB4jI9eB5lLcao38RAc1co4dHs7nwzgstrodpBplz9TITemLUM3VyE1RjGRZ08tF0_eZBMeyRhelQ0PsWLPrIVPIJvhps8gYoIdGHc48vXgN8t1Czej4P3NPyIZT5rGIU1LNRxM4QzSSR-fFaPwEJ5fVrQ |
| linkProvider | American Chemical Society |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3JTsMwELVQOZQL-74ZxIFLKhI3scOtKlRlq4raSr1FrjOuEKFFbXqAr2fsJmVRERwTOc7I43jei8dvCDnDkNTzQi92TBUfJCg-cyQHiUCOCym1lCBtlm8jqHfKt12_m8nkmLMwaMQYexrbTfxPdQEjE4TkBYMpLreLCEI8M5sr1dbnGUhPuDnU5SJguYrQ10dNBFLj7xHoF1hpw0ttZVqnyBpms0qeS5O0V1LvPzQb_2f5KlnOUCatTKfFGlmAwTopVvPibhvksQWJdqrGQMfQUYhpc5i8vcCI4no77GPEvKQVav6moesSsHfNCZYnRa9Gkz69gsRkdLzRZiJTA3w3Sad23a7Wnay6giOZ66eOFuByJY0eGVc-hAziWJSVlkHAY58zyTgLAhH3JDI-cIVCbhPiRTmQLggdsi1SGAwHsEOoC4gyY8QKjKsyj5Gf61BzKS60Rraiw11yhAMTZV_HOLIb3x4Sj3xkdsl57pJIZdrkpkRGMq_p6azp61SQY16jk9yvEQ6s2QORAxhO8NVmyTGwD43anjp81g2yX6tttPeXucekWG8_3Ef3N427fbLk5Rku4oAU0tEEDhGnpL0jO0E_ALiY3g4 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3JTsMwELUQSMCFfd8M4sAliMRN7HCrWio2QREgcYtce1whQova9ABfz0yalEUgOCZykpHH9rwXj98wto8hqRXEgfWoig8SlFB4WoJGICeV1k5r0HmW71V0el85fwgfCqJIZ2HQiD6-qZ9v4tOsfrGuUBggqSAkMBhQccmdoO06GtHV2u3HOchA-SXclSoSpZLQ50cpCpn-1yj0C7TMQ0xjll2PjMszS54OB1nr0Lx90238v_VzbKZAm7w6HB7zbAw6C2yqVhZ5W2Q3t5A6r0ZGekRLwfJmN319hh7Hdbfbxsh5zKuc_qqhC1PI79JJlkfD671Bm9chpcyOV95MdUYAeIndN07uaqdeUWXB08IPM88p8KXRpEsmTQixAGtVxTgdRdKGUmghRRQp29LI_MBXBjlOjBeVSPugXCyW2Xin24FVxn1AtGkRMwhpKtIiT3exk1odOYesxcVrbBs7JylmST_JN8ADJCBlz6yxg9ItiSk0yqlURvpT071R05ehMMdPjXZL3ybYsbQXojvQHeCnaekh-IdGrQydPnoNsuBc42j9L3N32GSz3kguz64uNth0UCa6qE02nvUGsIVwJWtt52P0HSda4JE |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Self-cross-linked+polymer+nanogels%3A+a+versatile+nanoscopic+drug+delivery+platform&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.au=Ryu%2C+Ja-Hyoung&rft.au=Chacko%2C+Reuben+T&rft.au=Jiwpanich%2C+Siriporn&rft.au=Bickerton%2C+Sean&rft.date=2010-12-08&rft.issn=1520-5126&rft.eissn=1520-5126&rft.volume=132&rft.issue=48&rft.spage=17227&rft_id=info:doi/10.1021%2Fja1069932&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-7863&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-7863&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-7863&client=summon |