Palladium-Catalyzed α‑Arylation of Sultams with Aryl and Heteroaryl Iodides

• Published in: Organic letters Vol. 16; no. 13; pp. 3468 - 3471
• Main Authors: René, Olivier, Fauber, Benjamin P, Malhotra, Sushant, Yajima, Herbert
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 03.07.2014; Amer Chemical Soc
• Subjects: Catalysis; Chemistry; Chemistry, Organic; Hydrocarbons, Iodinated - chemistry; Magnetic Resonance Spectroscopy; Molecular Structure; Palladium - chemistry; Physical Sciences; Science & Technology; Sulfonamides - chemical synthesis; Sulfonamides - chemistry; BORANE ADDUCTS; HALIDES; DESIGN; STRATEGY; ESTERS; SULFONAMIDES; INHIBITORS; MOLECULAR ADDITION-COMPOUNDS; AMIDES

Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadl...