Delivery of Lipid Micelles into Infarcted Myocardium Using a Lipid-Linked Matrix Metalloproteinase Targeting Peptide

• Published in: Molecular pharmaceutics Vol. 12; no. 4; pp. 1150 - 1157
• Main Authors: Nguyen, Juliane, Sievers, Richard, Motion, J. P. Michael, Kivimäe, Saul, Fang, Qizhi, Lee, Randall J
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.04.2015
• Subjects: Animals; Cell Separation; Drug Carriers; Drug Delivery Systems; Flow Cytometry; Heart - drug effects; Humans; Immunohistochemistry; Lipids - chemistry; Macrophages - drug effects; Male; Matrix Metalloproteinases - chemistry; Mice; Mice, Inbred C57BL; Micelles; Myocardial Infarction - drug therapy; Necrosis; Peptides - chemistry; Regeneration; U937 Cells; drug targeting; matrix metalloproteinase; targeted micellar vehicles; myocardial infarction

There is a great need for delivery strategies capable of efficiently localizing drugs to the damaged myocardium that do not require direct intramyocardial injection of therapeutic molecules. In the work discussed here, we exploited the myocardium-specific upregulation of matrix metalloproteinases (M...