Novel Glycobiomarker for Ovarian Cancer That Detects Clear Cell Carcinoma

• Published in: Journal of proteome research Vol. 13; no. 3; pp. 1624 - 1635
• Main Authors: Sogabe, Maki, Nozaki, Hirofumi, Tanaka, Nana, Kubota, Tomomi, Kaji, Hiroyuki, Kuno, Atsushi, Togayachi, Akira, Gotoh, Masanori, Nakanishi, Hayao, Nakanishi, Toru, Mikami, Mikio, Suzuki, Nao, Kiguchi, Kazushige, Ikehara, Yuzuru, Narimatsu, Hisashi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.03.2014
• Subjects: Adenocarcinoma, Clear Cell - chemistry; Adenocarcinoma, Clear Cell - diagnosis; Ascitic Fluid - chemistry; Biomarkers, Tumor - analysis; CA-125 Antigen - analysis; Carcinoma, Ovarian Epithelial; Ceruloplasmin - analysis; Ceruloplasmin - chemistry; Chromatography, Liquid; Female; Glycoproteins - analysis; Humans; Mass Spectrometry; Neoplasms, Glandular and Epithelial - chemistry; Neoplasms, Glandular and Epithelial - diagnosis; Ovarian Neoplasms - chemistry; Ovarian Neoplasms - diagnosis; Plant Lectins - chemistry; Polysaccharides - analysis; Polysaccharides - chemistry; Protein Array Analysis; Receptors, N-Acetylglucosamine - chemistry; glycan alteration; glycoproteomics; ceruloplasmin; WFA; clear cell carcinoma; lectin microarray; glycoprotein; epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is often asymptomatic and thus diagnosed at advanced stages with a poor prognosis. False-negative results for the conventional marker CA125 frequently occur in cases of clear cell carcinoma (CCC), a type of EOC; therefore, it is necessary to develop biomarkers with gr...