Mechanism of the Antioxidant Action of Silybin and 2,3-Dehydrosilybin Flavonolignans: A Joint Experimental and Theoretical Study

• Published in: The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory Vol. 112; no. 5; pp. 1054 - 1063
• Main Authors: Trouillas, Patrick, Marsal, Philippe, Svobodová, Alena, Vostálová, Jitka, Gažák, Radek, Hrbáč, Jan, Sedmera, Petr, Křen, Vladimír, Lazzaroni, Roberto, Duroux, Jean-Luc, Walterová, Daniela
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.02.2008
• Subjects: Antioxidants - chemistry; Flavonolignans - chemistry; Hydrogen - chemistry; Ions - chemistry; Models, Chemical; Models, Molecular; Molecular Structure; Silymarin - chemistry; Thermodynamics

Flavonolignans from silymarin, the standardized plant extract obtained from thistle, exhibit various antioxidant activities, which correlate with the other biological and therapeutic properties of that extract. To highlight the mode of action of flavonolignans as free radical scavengers and antioxid...