Multiple-dose efficacy comparison of the two topical carbonic anhydrase inhibitors sezolamide and MK-927

• Published in: Archives of ophthalmology (1960) Vol. 109; no. 1; p. 50
• Main Authors: Bron, A, Lippa, E A, Gunning, F, Bénichou, C, Lesure, P, Sirbat, D, Royer, J, Flament, J, Clineschmidt, C, Panebianco, D
• Format: Journal Article
• Language: English
• Published: United States 01.01.1991
• Subjects: Administration, Topical; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors - administration & dosage; Carbonic Anhydrase Inhibitors - therapeutic use; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glaucoma, Open-Angle - drug therapy; Humans; Intraocular Pressure - drug effects; Male; Middle Aged; Ocular Hypertension - drug therapy; Stereoisomerism; Sulfonamides - therapeutic use; Thiophenes - therapeutic use

The multiple-dose twice-daily efficacy of the topical carbonic anhydrase inhibitor MK-927, a racemic compound, was compared with that of its pharmacologically more active S-enantiomer in a four-center, double-masked, randomized, placebo-controlled, parallel study of 1.8% sezolamide hydrochloride (MK...