Cyclocarbopalladation/Cross-Coupling Cascade Reactions in Sulfide Series: Access to Sulfur Heterocycles

• Published in: Organic letters Vol. 16; no. 11; pp. 3060 - 3063
• Main Authors: Castanheiro, Thomas, Donnard, Morgan, Gulea, Mihaela, Suffert, Jean
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 06.06.2014; Amer Chemical Soc
• Subjects: Catalysis; Chemistry; Chemistry, Organic; Coordination Complexes - chemistry; Heterocyclic Compounds - chemical synthesis; Heterocyclic Compounds - chemistry; Molecular Structure; Palladium - chemistry; Physical Sciences; Science & Technology; Stereoisomerism; Sulfhydryl Compounds - chemical synthesis; Sulfhydryl Compounds - chemistry; Sulfides - chemistry; CATALYZED C-S; ARYLATION; EFFICIENT SYNTHESIS; BOND FORMATION; CARBOPALLADATION; ARYL IODIDES; ALKYNES; TETRASUBSTITUTED OLEFINS; SUZUKI-MIYAURA; CYCLIZATION

Cyclocarbopalladation/cross-coupling cascade reactions were applied for the first time in a sulfur series and represent an efficient route to access sulfur heterocycles. Stille or Suzuki–Miyaura cross-coupling was successfully used as the final reaction. The products are original benzothiolane and i...