Cu(II)-Mediated Ortho C–H Alkynylation of (Hetero)Arenes with Terminal Alkynes

Cu(II)-promoted ortho alkynylation of arenes and heteroarenes with terminal alkynes has been developed to prepare aryl alkynes. A variety of arenes and terminal alkynes bearing different substituents are compatible with this reaction, thus providing an alternative disconnection to Sonogashira coupli...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 136; no. 33; pp. 11590 - 11593
Main Authors Shang, Ming, Wang, Hong-Li, Sun, Shang-Zheng, Dai, Hui-Xiong, Yu, Jin-Quan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 20.08.2014
Amer Chemical Soc
Subjects
Alkylation
Alkynes - chemical synthesis
Alkynes - chemistry
Benzene Derivatives - chemistry
Chemistry
Chemistry, Multidisciplinary
Copper - chemistry
Molecular Structure
Physical Sciences
Science & Technology
CATALYZED DIRECT ALKYNYLATION
ACETYLENES
CROSS-COUPLING REACTIONS
ACTIVATION
ETHYNYLATION
HETEROCYCLES
ARENES
CHEMISTRY
BOND FORMATION
CARBOXYLIC-ACIDS
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Summary:Cu(II)-promoted ortho alkynylation of arenes and heteroarenes with terminal alkynes has been developed to prepare aryl alkynes. A variety of arenes and terminal alkynes bearing different substituents are compatible with this reaction, thus providing an alternative disconnection to Sonogashira coupling.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja507704b