Whole-blood serotonin and cognitive functioning in autistic individuals and their first-degree relatives

The relationship between cognitive-intellectual abilities and whole- blood serotonin (5-hydroxytryptamine; 5-HT) in 18 autistic probands and their first-degree relatives (n = 21 parents, n = 13 siblings) was investigated. Whole-blood 5-HT was significantly negatively associated with verbal-expressiv...

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Published inThe journal of neuropsychiatry and clinical neurosciences Vol. 5; no. 1; pp. 94 - 101
Main Authors Cuccaro, M L, Wright, H H, Abramson, R K, Marsteller, F A, Valentine, J
Format Journal Article
LanguageEnglish
Published United States American Psychiatric Publishing 1993
Subjects
Adolescent
Adult
Autistic Disorder - blood
Autistic Disorder - complications
Autistic Disorder - diagnosis
Cognition Disorders - blood
Cognition Disorders - complications
Cognition Disorders - diagnosis
Family Health
Female
Humans
Male
Middle Aged
Serotonin - blood
Verbal Behavior
Wechsler Scales
Online AccessGet full text

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Abstract The relationship between cognitive-intellectual abilities and whole- blood serotonin (5-hydroxytryptamine; 5-HT) in 18 autistic probands and their first-degree relatives (n = 21 parents, n = 13 siblings) was investigated. Whole-blood 5-HT was significantly negatively associated with verbal-expressive/symbolic abilities for the entire sample. The proportion of variance in cognitive-intellectual performances attributable to whole-blood 5-HT was substantial in the context of variance attributable to familial classification. The relationship between verbal-expressive abilities and whole-blood 5-HT, adjusted for race and familial classification, was noteworthy. Simple correlations between 5-HT and cognitive-intellectual performances were conducted. However, bias related to covariance attributable to race seriously limits such findings. The issue of bias and its relevance to previous research is discussed further.
AbstractList The relationship between cognitive-intellectual abilities and whole-blood serotonin (5-hydroxytryptamine; 5-HT) in 18 autistic probands and their first-degree relatives (n = 21 parents, n = 13 siblings) was investigated. Whole-blood 5-HT was significantly negatively associated with verbal-expressive/symbolic abilities for the entire sample. The proportion of variance in cognitive-intellectual performances attributable to whole-blood 5-HT was substantial in the context of variance attributable to familial classification. The relationship between verbal-expressive abilities and whole-blood 5-HT, adjusted for race and familial classification, was noteworthy. Simple correlations between 5-HT and cognitive-intellectual performances were conducted. However, bias related to covariance attributable to race seriously limits such findings. The issue of bias and its relevance to previous research is discussed further.
The relationship between cognitive-intellectual abilities and whole- blood serotonin (5-hydroxytryptamine; 5-HT) in 18 autistic probands and their first-degree relatives (n = 21 parents, n = 13 siblings) was investigated. Whole-blood 5-HT was significantly negatively associated with verbal-expressive/symbolic abilities for the entire sample. The proportion of variance in cognitive-intellectual performances attributable to whole-blood 5-HT was substantial in the context of variance attributable to familial classification. The relationship between verbal-expressive abilities and whole-blood 5-HT, adjusted for race and familial classification, was noteworthy. Simple correlations between 5-HT and cognitive-intellectual performances were conducted. However, bias related to covariance attributable to race seriously limits such findings. The issue of bias and its relevance to previous research is discussed further.
Author Marsteller, F A
Wright, H H
Abramson, R K
Cuccaro, M L
Valentine, J
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Snippet The relationship between cognitive-intellectual abilities and whole- blood serotonin (5-hydroxytryptamine; 5-HT) in 18 autistic probands and their first-degree...
The relationship between cognitive-intellectual abilities and whole-blood serotonin (5-hydroxytryptamine; 5-HT) in 18 autistic probands and their first-degree...
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SubjectTerms Adolescent
Adult
Autistic Disorder - blood
Autistic Disorder - complications
Autistic Disorder - diagnosis
Cognition Disorders - blood
Cognition Disorders - complications
Cognition Disorders - diagnosis
Family Health
Female
Humans
Male
Middle Aged
Serotonin - blood
Verbal Behavior
Wechsler Scales
Title Whole-blood serotonin and cognitive functioning in autistic individuals and their first-degree relatives
URI http://dx.doi.org/10.1176/jnp.5.1.94
https://www.ncbi.nlm.nih.gov/pubmed/8428142
https://search.proquest.com/docview/75574481
Volume 5
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