Biphenyl-Substituted Oxazolidinones as Cholesteryl Ester Transfer Protein Inhibitors: Modifications of the Oxazolidinone Ring Leading to the Discovery of Anacetrapib - Smith, Cameron J; Ali, Amjad; Hammond, Milton L; Li, Hong; Lu, Zhijian; Napolitano, Joann; Taylor, Gayle E; Thompson, Christopher F; Anderson, Matt S; Chen, Ying; Eveland, Suzanne S; Guo, Qiu; et al. (Journal of medicinal chemistry, 2011)
Keywords: Animals; Chemistry, Medicinal; Cholesterol Ester Transfer Proteins - antagonists & inhibitors; Cholesterol Ester Transfer Proteins - chemistry; Cholesterol, HDL - blood; Humans; Life Sciences & Biomedicine; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxazolidinones - chemical synthesis; Oxazolidinones - pharmacokinetics; Oxazolidinones - pharmacology; Pharmacology & Pharmacy; Recombinant Proteins - chemistry; Science & Technology; Stereoisomerism; Structure-Activity Relationship; HEALTHY-SUBJECTS; HIGH-RISK; THERAPEUTIC TARGET; DOUBLE-BLIND; HDL CHOLESTEROL; CETP INHIBITOR; CORONARY-HEART-DISEASE; 14 RANDOMIZED-TRIALS; BLOOD-PRESSURE; HIGH-DENSITY-LIPOPROTEIN