Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus - Nomura, Sumihiro; Sakamaki, Shigeki; Hongu, Mitsuya; Kawanishi, Eiji; Koga, Yuichi; Sakamoto, Toshiaki; Yamamoto, Yasuo; Ueta, Kiichiro; Kimata, Hirotaka; Nakayama, Keiko; Tsuda-Tsukimoto, Minoru (Journal of medicinal chemistry, 2010)
Keywords: Animals; Biological Availability; Canagliflozin; Carbonates - pharmacology; Chemistry, Medicinal; Diabetes Mellitus, Type 2 - drug therapy; Glucosides - chemical synthesis; Glucosides - pharmacokinetics; Glucosides - pharmacology; Humans; Hypoglycemic Agents - chemical synthesis; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - pharmacology; Life Sciences & Biomedicine; Male; Mice; Pharmacology & Pharmacy; Rats; Rats, Sprague-Dawley; Science & Technology; Sodium-Glucose Transporter 2 - antagonists & inhibitors; Stereoisomerism; Structure-Activity Relationship; Thiophenes - chemical synthesis; Thiophenes - pharmacokinetics; Thiophenes - pharmacology; ANTIDIABETIC AGENTS; PREVALENCE; REDUCTION; MECHANISM; SGLT2 INHIBITORS; DERIVATIVES