A Sensing Platform Based on Electrodissolution of a Ag Bipolar Electrode
Here we report a new type of sensing platform that is based on electrodissolution of a metallic bipolar electrode (BPE). When the target DNA binds to the capture probe at the cathodic pole of the BPE, it triggers the oxidation and dissolution of Ag metal present at the anodic pole. The loss of Ag is...
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Published in | Journal of the American Chemical Society Vol. 132; no. 27; pp. 9228 - 9229 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
American Chemical Society
14.07.2010
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Abstract | Here we report a new type of sensing platform that is based on electrodissolution of a metallic bipolar electrode (BPE). When the target DNA binds to the capture probe at the cathodic pole of the BPE, it triggers the oxidation and dissolution of Ag metal present at the anodic pole. The loss of Ag is easily detectable with the naked eye or a magnifying glass and provides a permanent record of the electrochemical history of the electrode. More importantly, the decrease in the length of the BPE can be directly correlated to the number of electrons passing through the BPE and hence to the sensing reaction at the cathode. |
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AbstractList | Here we report a new type of sensing platform that is based on electrodissolution of a metallic bipolar electrode (BPE). When the target DNA binds to the capture probe at the cathodic pole of the BPE, it triggers the oxidation and dissolution of Ag metal present at the anodic pole. The loss of Ag is easily detectable with the naked eye or a magnifying glass and provides a permanent record of the electrochemical history of the electrode. More importantly, the decrease in the length of the BPE can be directly correlated to the number of electrons passing through the BPE and hence to the sensing reaction at the cathode. |
Author | Crooks, Richard M Mavré, François Zaccheo, Brian A Chow, Kwok-Fan Chang, Byoung-Yong |
Author_xml | – sequence: 1 givenname: Kwok-Fan surname: Chow fullname: Chow, Kwok-Fan – sequence: 2 givenname: Byoung-Yong surname: Chang fullname: Chang, Byoung-Yong – sequence: 3 givenname: Brian A surname: Zaccheo fullname: Zaccheo, Brian A – sequence: 4 givenname: François surname: Mavré fullname: Mavré, François – sequence: 5 givenname: Richard M surname: Crooks fullname: Crooks, Richard M email: crooks@cm.utexas.edu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20557051$$D View this record in MEDLINE/PubMed |
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