Equilibrium Study of Protein Denaturation by Urea

• Published in: Journal of the American Chemical Society Vol. 132; no. 7; pp. 2338 - 2344
• Main Authors: Canchi, Deepak R, Paschek, Dietmar, García, Angel E
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.02.2010
• Subjects: Computer Simulation; Kinetics; Models, Molecular; Peptides - chemistry; Protein Denaturation; Protein Folding; Thermodynamics; Urea - chemistry; Water - chemistry

Though urea is commonly used to denature proteins, the molecular mechanism of its denaturing ability is still a subject of considerable debate. Previous molecular dynamics simulation studies have sought to elucidate the mechanism of urea denaturation by focusing on the pathway of denaturation rather...