Hyperpolarized 13C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of l‑Lactate in Vivo - Takado, Yuhei; Cheng, Tian; Bastiaansen, Jessica A. M; Yoshihara, Hikari A. I; Lanz, Bernard; Mishkovsky, Mor; Lengacher, Sylvain; Comment, Arnaud (ACS Chemical Neuroscience, 2018)
Keywords: Animals; Blood-Brain Barrier/metabolism; Blood-Brain Barrier/radiation effects; Brain/metabolism; Brain/radiation effects; Carbon-13 Magnetic Resonance Spectroscopy; L-Lactate Dehydrogenase/genetics; L-Lactate Dehydrogenase/metabolism; Lactic Acid/metabolism; Lactic Acid/radiation effects; Male; Mice; Mice, Inbred C57BL; Pyruvic Acid/metabolism; Pyruvic Acid/radiation effects; Ultrasonic Waves; Hyperpolarization; bicarbonate; dynamic nuclear polarization; magnetic resonance spectroscopy; pyruvate; ultrasound; bicarbonate; CIBM-AIT; dynamic nuclear polarization; exchange; hyperpolarization; infusion; inhibition; ldh; magnetic resonance spectroscopy; mrs; pyruvate; substrate; ultrasound; magnetic resonance spectroscopy; dynamic nuclear polarization; bicarbonate; pyruvate; Hyperpolarization; ultrasound