Nitrosative Stress in the ER: A New Role for S-Nitrosylation in Neurodegenerative Diseases
S-Nitrosylation, the covalent addition of a nitrogen monoxide group to a cysteine thiol, has been shown to modify the function of a broad spectrum of mammalian, plant, and microbial proteins and thereby to convey the ubiquitous influence of nitric oxide on cellular signal transduction and host defen...
Saved in:
| Published in | ACS chemical biology Vol. 1; no. 6; pp. 355 - 358 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
21.07.2006
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | S-Nitrosylation, the covalent addition of a nitrogen monoxide group to a cysteine thiol, has been shown to modify the function of a broad spectrum of mammalian, plant, and microbial proteins and thereby to convey the ubiquitous influence of nitric oxide on cellular signal transduction and host defense. Accumulating evidence indicates that dysregulated, diminished, or excessive S-nitrosylation may be implicated in a wide range of pathophysiological conditions. A recent study establishes a functional relationship between inhibitory S-nitrosylation of the redox enzyme protein disulfide isomerase (PDI), defects in regulation of protein folding within the endoplasmic reticulum (ER), and neurodegeneration. Further, an examination of human brains afflicted with Parkinson’s or Alzheimer’s disease supports a causal role for the S-nitrosylation of PDI and consequent ER stress in these prevalent neurodegenerative disorders. |
|---|---|
| AbstractList | S-Nitrosylation, the covalent addition of a nitrogen monoxide group to a cysteine thiol, has been shown to modify the function of a broad spectrum of mammalian, plant, and microbial proteins and thereby to convey the ubiquitous influence of nitric oxide on cellular signal transduction and host defense. Accumulating evidence indicates that dysregulated, diminished, or excessive S-nitrosylation may be implicated in a wide range of pathophysiological conditions. A recent study establishes a functional relationship between inhibitory S-nitrosylation of the redox enzyme protein disulfide isomerase (PDI), defects in regulation of protein folding within the endoplasmic reticulum (ER), and neurodegeneration. Further, an examination of human brains afflicted with Parkinson’s or Alzheimer’s disease supports a causal role for the S-nitrosylation of PDI and consequent ER stress in these prevalent neurodegenerative disorders. |
| Author | Benhar, Moran Forrester, Michael T Stamler, Jonathan S |
| Author_xml | – sequence: 1 givenname: Michael T surname: Forrester fullname: Forrester, Michael T – sequence: 2 givenname: Moran surname: Benhar fullname: Benhar, Moran – sequence: 3 givenname: Jonathan S surname: Stamler fullname: Stamler, Jonathan S email: staml001@mc.duke.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17163772$$D View this record in MEDLINE/PubMed |
| BookMark | eNpt0D1PwzAQBmALFdEPGPgDyAtIDAHbseOErSrlQ6qK1MLCEjnOGVKlcbETUP89qVKVhelueO6V7h2iXmUrQOickhtKGL3VWUQI41wfoQEVggdxEsreYWdJHw29XxHCwyhOTlCfShqFUrIBep8XtbNe1cU34GXtwHtcVLj-BDxd3OExnsMPXtgSsLEOL4OOb8v2wFY7OYfG2Rw-oALXpdwXHpQHf4qOjSo9nO3nCL09TF8nT8Hs5fF5Mp4FKqRhHRiT8RA4gVhopVTGaBZCLjihUgGRTBstBDGMQU6yRNJYJZSzRMU5N0pIGo7QVZe7cfarAV-n68JrKEtVgW18GsWMR4LzFl53ULcveAcm3bhirdw2pSTdFZkeimztxT60ydaQ_8l9cy247IDSPl3ZxlXtj_8E_QKjMXtm |
| CitedBy_id | crossref_primary_10_1080_14728222_2016_1254197 crossref_primary_10_1016_j_ccr_2012_05_007 crossref_primary_10_1021_acsomega_0c01819 crossref_primary_10_1016_j_cellsig_2018_10_019 crossref_primary_10_1089_ars_2012_4716 crossref_primary_10_1089_ars_2010_3570 crossref_primary_10_1021_acs_inorgchem_7b02333 crossref_primary_10_1186_s13578_022_00868_6 crossref_primary_10_1038_cddis_2013_113 crossref_primary_10_1038_nrd2755 crossref_primary_10_1007_s12013_016_0726_9 crossref_primary_10_1038_onc_2008_307 crossref_primary_10_1016_j_bbrc_2010_11_117 crossref_primary_10_1016_j_brainres_2023_148742 crossref_primary_10_1016_j_brainres_2016_04_010 crossref_primary_10_1002_ange_202102589 crossref_primary_10_1007_s10571_015_0312_5 crossref_primary_10_1007_s12035_010_8113_9 crossref_primary_10_1155_2013_797914 crossref_primary_10_4161_psb_3_5_5277 crossref_primary_10_18097_pbmc20105602209 crossref_primary_10_1016_j_biomag_2014_03_006 crossref_primary_10_1096_fj_08_128330 crossref_primary_10_3390_ph15060649 crossref_primary_10_1016_j_tplants_2007_08_013 crossref_primary_10_4161_psb_4_10_9466 crossref_primary_10_1111_j_1474_9726_2007_00284_x crossref_primary_10_3892_ijmm_2013_1241 crossref_primary_10_1016_j_arr_2021_101336 crossref_primary_10_1016_j_bbrc_2010_01_071 crossref_primary_10_1152_ajpendo_00510_2010 crossref_primary_10_1016_j_bbagen_2011_08_012 crossref_primary_10_1007_s10495_008_0301_y crossref_primary_10_1038_sj_cdd_4402138 crossref_primary_10_1038_s12276_021_00560_8 crossref_primary_10_3390_antiox11020416 crossref_primary_10_1021_ic902181e crossref_primary_10_1089_ars_2007_1858 crossref_primary_10_3389_fcell_2015_00080 crossref_primary_10_3389_fnmol_2017_00005 crossref_primary_10_1016_j_redox_2018_10_002 crossref_primary_10_1002_rcm_5219 crossref_primary_10_1007_s12035_018_1028_6 crossref_primary_10_3390_biomedicines11112925 crossref_primary_10_1021_acs_chemrev_1c00253 crossref_primary_10_1038_srep24227 crossref_primary_10_4161_psb_6_6_15161 crossref_primary_10_1016_j_neuint_2022_105281 crossref_primary_10_1021_bi801805h crossref_primary_10_1021_cn500214k crossref_primary_10_1007_s12035_013_8562_z crossref_primary_10_1016_j_freeradbiomed_2011_03_032 crossref_primary_10_1134_S1990750809030056 crossref_primary_10_1021_acschemneuro_6b00159 crossref_primary_10_1002_anie_202102589 crossref_primary_10_3389_fcell_2015_00030 crossref_primary_10_1089_ars_2012_5099_test |
| Cites_doi | 10.1038/nm1314 10.1038/ncb1188 10.1038/35040009 10.1038/ncb1268 10.1073/pnas.95.13.7631 10.1021/bi0603064 10.1172/JCI4890 10.1038/ncb1080 10.1093/emboj/20.22.6288 10.1016/S1367-5931(02)00383-6 10.1172/JCI200419267 10.1172/JCI26373 10.1038/nrm1052 10.1038/sj.onc.1207108 10.1021/ja029655l 10.1146/annurev.ph.57.030195.003343 10.1038/nature04782 10.1073/pnas.0600729103 10.1126/science.1073634 10.1073/pnas.171180998 10.1021/ja0529135 10.1038/nchembio720 10.1016/j.brainres.2004.04.022 10.1038/nrn1868 10.1038/sj.embor.7400311 10.1126/science.1093891 10.1023/A:1007604414773 10.1046/j.1471-4159.2003.01938.x 10.1074/jbc.M408080200 10.1038/35055104 10.1074/jbc.M404992200 10.1016/j.pharmthera.2005.05.007 10.1038/sj.cdd.4401778 10.1021/bi00077a018 10.1212/01.wnl.0000192306.98198.ec 10.1161/01.ATV.0000223900.67024.15 10.1016/S0014-5793(99)00788-7 10.1006/abbi.1995.1231 10.1073/pnas.88.14.6368 10.1073/pnas.0503723102 |
| ContentType | Journal Article |
| Copyright | Copyright © 2006 American Chemical Society |
| Copyright_xml | – notice: Copyright © 2006 American Chemical Society |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1021/cb600244c |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1554-8937 |
| EndPage | 358 |
| ExternalDocumentID | 10_1021_cb600244c 17163772 b666610880 |
| Genre | Journal Article Review |
| GroupedDBID | - 23M 4.4 53G 55A 5GY 5VS 7~N AABXI ABMVS ABUCX ACGFS ACS AEESW AENEX AFEFF ALMA_UNASSIGNED_HOLDINGS AQSVZ BAANH CS3 D0L EBS ED ED~ EJD F5P GNL GX1 IH9 IHE JG JG~ LG6 P2P RNS ROL UI2 VF5 VG9 W1F --- 5ZA 6J9 ABJNI ABQRX ACGFO ADHLV AHGAQ CGR CUPRZ CUY CVF ECM EIF GGK NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-a313t-ffb43e40e85caaab21b3ed54017ae072cfc550f22ed0b9718a91429a8d4fa5713 |
| IEDL.DBID | ACS |
| ISSN | 1554-8929 |
| IngestDate | Fri Aug 16 07:06:41 EDT 2024 Fri Aug 23 02:30:14 EDT 2024 Sat Sep 28 07:54:30 EDT 2024 Thu Aug 27 13:42:08 EDT 2020 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a313t-ffb43e40e85caaab21b3ed54017ae072cfc550f22ed0b9718a91429a8d4fa5713 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| PMID | 17163772 |
| PQID | 68246544 |
| PQPubID | 23479 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_68246544 crossref_primary_10_1021_cb600244c pubmed_primary_17163772 acs_journals_10_1021_cb600244c |
| ProviderPackageCode | JG~ 55A AABXI GNL VF5 7~N VG9 W1F ACS AEESW AFEFF ABMVS ABUCX IH9 BAANH AQSVZ ED~ UI2 |
| PublicationCentury | 2000 |
| PublicationDate | 2006-Jul-21 |
| PublicationDateYYYYMMDD | 2006-07-21 |
| PublicationDate_xml | – month: 07 year: 2006 text: 2006-Jul-21 day: 21 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | ACS chemical biology |
| PublicationTitleAlternate | ACS Chem. Biol |
| PublicationYear | 2006 |
| Publisher | American Chemical Society |
| Publisher_xml | – name: American Chemical Society |
| References | Lundstrom J. (cb-2006-00244c-ref38/cb-2006-00244c-ref38_1) 1993; 32 Clementi E. (cb-2006-00244c-ref18/cb-2006-00244c-ref18_1) 1998; 95 Xu C. (cb-2006-00244c-ref19/cb-2006-00244c-ref19_1) 2005; 115 Gotoh T. (cb-2006-00244c-ref25/cb-2006-00244c-ref25_1) 2006; 26 Breckenridge D. G. (cb-2006-00244c-ref22/cb-2006-00244c-ref22_1) 2003; 22 Zhang K. (cb-2006-00244c-ref21/cb-2006-00244c-ref21_1) 2006; 66 Ellgaard L. (cb-2006-00244c-ref27/cb-2006-00244c-ref27_1) 2005; 6 Almeida A. (cb-2006-00244c-ref12/cb-2006-00244c-ref12_1) 2004; 6 Kozlov A. V. (cb-2006-00244c-ref17/cb-2006-00244c-ref17_1) 1999; 454 Ramachandran N. (cb-2006-00244c-ref33/cb-2006-00244c-ref33_1) 2001; 98 Houk K. N. (cb-2006-00244c-ref28/cb-2006-00244c-ref28_1) 2003; 125 Mezghrani A. (cb-2006-00244c-ref30/cb-2006-00244c-ref30_1) 2001; 20 Garthwaite J. (cb-2006-00244c-ref1/cb-2006-00244c-ref1_1) 1995; 57 Zhang L. (cb-2006-00244c-ref11/cb-2006-00244c-ref11_1) 2006; 109 Uehara T. (cb-2006-00244c-ref4/cb-2006-00244c-ref4_1) 2006; 441 Xu W. (cb-2006-00244c-ref23/cb-2006-00244c-ref23_1) 2004; 6 Stamler J. S. (cb-2006-00244c-ref40/cb-2006-00244c-ref40_1) 2002; 6 He Y. (cb-2006-00244c-ref15/cb-2006-00244c-ref15_1) 2003; 86 Hara M. R. (cb-2006-00244c-ref7/cb-2006-00244c-ref7_1) 2005; 7 Gu Z. (cb-2006-00244c-ref8/cb-2006-00244c-ref8_1) 2002; 297 Sliskovic I. (cb-2006-00244c-ref32/cb-2006-00244c-ref32_1) 2005; 280 Sydow K. (cb-2006-00244c-ref10/cb-2006-00244c-ref10_1) 2004; 113 Mitchell D. A. (cb-2006-00244c-ref35/cb-2006-00244c-ref35_1) 2005; 1 He J. (cb-2006-00244c-ref26/cb-2006-00244c-ref26_1) 2004; 1015 Stoyanovsky D. A. (cb-2006-00244c-ref36/cb-2006-00244c-ref36_1) 2005; 127 Dawson V. L. (cb-2006-00244c-ref5/cb-2006-00244c-ref5_1) 1991; 88 LaVoie M. J. (cb-2006-00244c-ref13/cb-2006-00244c-ref13_1) 2005; 11 Calabrese V. (cb-2006-00244c-ref2/cb-2006-00244c-ref2_1) 2000; 25 Ellgaard L. (cb-2006-00244c-ref20/cb-2006-00244c-ref20_1) 2003; 4 Greco T. M. (cb-2006-00244c-ref29/cb-2006-00244c-ref29_1) 2006; 103 Molteni S. N. (cb-2006-00244c-ref31/cb-2006-00244c-ref31_1) 2004; 279 Zai A. (cb-2006-00244c-ref34/cb-2006-00244c-ref34_1) 1999; 103 Jaffrey S. R. (cb-2006-00244c-ref6/cb-2006-00244c-ref6_1) 2001; 3 Abou-Sleiman P. M. (cb-2006-00244c-ref16/cb-2006-00244c-ref16_1) 2006; 7 Lindholm D. (cb-2006-00244c-ref24/cb-2006-00244c-ref24_1) 2006; 13 Mattson M. P. (cb-2006-00244c-ref3/cb-2006-00244c-ref3_1) 2000; 1 Arnelle D. R. (cb-2006-00244c-ref37/cb-2006-00244c-ref37_1) 1995; 318 Chen Z. (cb-2006-00244c-ref9/cb-2006-00244c-ref9_1) 2005; 102 Chung K. K. (cb-2006-00244c-ref14/cb-2006-00244c-ref14_1) 2004; 304 Schmidt B. (cb-2006-00244c-ref39/cb-2006-00244c-ref39_1) 2006; 45 |
| References_xml | – volume: 11 start-page: 1214 year: 2005 ident: cb-2006-00244c-ref13/cb-2006-00244c-ref13_1 publication-title: Nat. Med. doi: 10.1038/nm1314 contributor: fullname: LaVoie M. J. – volume: 6 start-page: 1129 year: 2004 ident: cb-2006-00244c-ref23/cb-2006-00244c-ref23_1 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1188 contributor: fullname: Xu W. – volume: 1 start-page: 120 year: 2000 ident: cb-2006-00244c-ref3/cb-2006-00244c-ref3_1 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/35040009 contributor: fullname: Mattson M. P. – volume: 7 start-page: 665 year: 2005 ident: cb-2006-00244c-ref7/cb-2006-00244c-ref7_1 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1268 contributor: fullname: Hara M. R. – volume: 95 start-page: 7631 year: 1998 ident: cb-2006-00244c-ref18/cb-2006-00244c-ref18_1 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.95.13.7631 contributor: fullname: Clementi E. – volume: 45 start-page: 7429 year: 2006 ident: cb-2006-00244c-ref39/cb-2006-00244c-ref39_1 publication-title: Biochemistry doi: 10.1021/bi0603064 contributor: fullname: Schmidt B. – volume: 103 start-page: 393 year: 1999 ident: cb-2006-00244c-ref34/cb-2006-00244c-ref34_1 publication-title: J. Clin. Invest. doi: 10.1172/JCI4890 contributor: fullname: Zai A. – volume: 6 start-page: 45 year: 2004 ident: cb-2006-00244c-ref12/cb-2006-00244c-ref12_1 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1080 contributor: fullname: Almeida A. – volume: 20 start-page: 6288 year: 2001 ident: cb-2006-00244c-ref30/cb-2006-00244c-ref30_1 publication-title: EMBO J. doi: 10.1093/emboj/20.22.6288 contributor: fullname: Mezghrani A. – volume: 6 start-page: 779 year: 2002 ident: cb-2006-00244c-ref40/cb-2006-00244c-ref40_1 publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/S1367-5931(02)00383-6 contributor: fullname: Stamler J. S. – volume: 113 start-page: 482 year: 2004 ident: cb-2006-00244c-ref10/cb-2006-00244c-ref10_1 publication-title: J. Clin. Invest. doi: 10.1172/JCI200419267 contributor: fullname: Sydow K. – volume: 115 start-page: 2656 year: 2005 ident: cb-2006-00244c-ref19/cb-2006-00244c-ref19_1 publication-title: J. Clin. Invest. doi: 10.1172/JCI26373 contributor: fullname: Xu C. – volume: 4 start-page: 181 year: 2003 ident: cb-2006-00244c-ref20/cb-2006-00244c-ref20_1 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1052 contributor: fullname: Ellgaard L. – volume: 22 start-page: 8608 year: 2003 ident: cb-2006-00244c-ref22/cb-2006-00244c-ref22_1 publication-title: Oncogene doi: 10.1038/sj.onc.1207108 contributor: fullname: Breckenridge D. G. – volume: 125 start-page: 6972 year: 2003 ident: cb-2006-00244c-ref28/cb-2006-00244c-ref28_1 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja029655l contributor: fullname: Houk K. N. – volume: 57 start-page: 683 year: 1995 ident: cb-2006-00244c-ref1/cb-2006-00244c-ref1_1 publication-title: Annu. Rev. Physiol. doi: 10.1146/annurev.ph.57.030195.003343 contributor: fullname: Garthwaite J. – volume: 441 start-page: 513 year: 2006 ident: cb-2006-00244c-ref4/cb-2006-00244c-ref4_1 publication-title: Nature doi: 10.1038/nature04782 contributor: fullname: Uehara T. – volume: 103 start-page: 7420 year: 2006 ident: cb-2006-00244c-ref29/cb-2006-00244c-ref29_1 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0600729103 contributor: fullname: Greco T. M. – volume: 297 start-page: 1186 year: 2002 ident: cb-2006-00244c-ref8/cb-2006-00244c-ref8_1 publication-title: Science doi: 10.1126/science.1073634 contributor: fullname: Gu Z. – volume: 98 start-page: 9539 year: 2001 ident: cb-2006-00244c-ref33/cb-2006-00244c-ref33_1 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.171180998 contributor: fullname: Ramachandran N. – volume: 127 start-page: 15815 year: 2005 ident: cb-2006-00244c-ref36/cb-2006-00244c-ref36_1 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja0529135 contributor: fullname: Stoyanovsky D. A. – volume: 1 start-page: 154 year: 2005 ident: cb-2006-00244c-ref35/cb-2006-00244c-ref35_1 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio720 contributor: fullname: Mitchell D. A. – volume: 1015 start-page: 25 year: 2004 ident: cb-2006-00244c-ref26/cb-2006-00244c-ref26_1 publication-title: Brain Res. doi: 10.1016/j.brainres.2004.04.022 contributor: fullname: He J. – volume: 7 start-page: 207 year: 2006 ident: cb-2006-00244c-ref16/cb-2006-00244c-ref16_1 publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn1868 contributor: fullname: Abou-Sleiman P. M. – volume: 6 start-page: 28 year: 2005 ident: cb-2006-00244c-ref27/cb-2006-00244c-ref27_1 publication-title: EMBO Rep. doi: 10.1038/sj.embor.7400311 contributor: fullname: Ellgaard L. – volume: 304 start-page: 1328 year: 2004 ident: cb-2006-00244c-ref14/cb-2006-00244c-ref14_1 publication-title: Science doi: 10.1126/science.1093891 contributor: fullname: Chung K. K. – volume: 25 start-page: 1315 year: 2000 ident: cb-2006-00244c-ref2/cb-2006-00244c-ref2_1 publication-title: Neurochem. Res. doi: 10.1023/A:1007604414773 contributor: fullname: Calabrese V. – volume: 86 start-page: 1338 year: 2003 ident: cb-2006-00244c-ref15/cb-2006-00244c-ref15_1 publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2003.01938.x contributor: fullname: He Y. – volume: 280 start-page: 8733 year: 2005 ident: cb-2006-00244c-ref32/cb-2006-00244c-ref32_1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M408080200 contributor: fullname: Sliskovic I. – volume: 3 start-page: 193 year: 2001 ident: cb-2006-00244c-ref6/cb-2006-00244c-ref6_1 publication-title: Nat. Cell Biol. doi: 10.1038/35055104 contributor: fullname: Jaffrey S. R. – volume: 279 start-page: 32667 year: 2004 ident: cb-2006-00244c-ref31/cb-2006-00244c-ref31_1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M404992200 contributor: fullname: Molteni S. N. – volume: 109 start-page: 33 year: 2006 ident: cb-2006-00244c-ref11/cb-2006-00244c-ref11_1 publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2005.05.007 contributor: fullname: Zhang L. – volume: 13 start-page: 385 year: 2006 ident: cb-2006-00244c-ref24/cb-2006-00244c-ref24_1 publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401778 contributor: fullname: Lindholm D. – volume: 32 start-page: 6649 year: 1993 ident: cb-2006-00244c-ref38/cb-2006-00244c-ref38_1 publication-title: Biochemistry doi: 10.1021/bi00077a018 contributor: fullname: Lundstrom J. – volume: 66 start-page: S102 year: 2006 ident: cb-2006-00244c-ref21/cb-2006-00244c-ref21_1 publication-title: Neurology doi: 10.1212/01.wnl.0000192306.98198.ec contributor: fullname: Zhang K. – volume: 26 start-page: 1439 year: 2006 ident: cb-2006-00244c-ref25/cb-2006-00244c-ref25_1 publication-title: Arterioscler. Thromb., Vasc. Biol. doi: 10.1161/01.ATV.0000223900.67024.15 contributor: fullname: Gotoh T. – volume: 454 start-page: 127 year: 1999 ident: cb-2006-00244c-ref17/cb-2006-00244c-ref17_1 publication-title: FEBS Lett. doi: 10.1016/S0014-5793(99)00788-7 contributor: fullname: Kozlov A. V. – volume: 318 start-page: 279 year: 1995 ident: cb-2006-00244c-ref37/cb-2006-00244c-ref37_1 publication-title: Arch. Biochem. Biophys. doi: 10.1006/abbi.1995.1231 contributor: fullname: Arnelle D. R. – volume: 88 start-page: 6368 year: 1991 ident: cb-2006-00244c-ref5/cb-2006-00244c-ref5_1 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.88.14.6368 contributor: fullname: Dawson V. L. – volume: 102 start-page: 12159 year: 2005 ident: cb-2006-00244c-ref9/cb-2006-00244c-ref9_1 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0503723102 contributor: fullname: Chen Z. |
| SSID | ssj0043689 |
| Score | 2.1030066 |
| SecondaryResourceType | review_article |
| Snippet | S-Nitrosylation, the covalent addition of a nitrogen monoxide group to a cysteine thiol, has been shown to modify the function of a broad spectrum of... |
| SourceID | proquest crossref pubmed acs |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 355 |
| SubjectTerms | Animals Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - metabolism Humans Neurodegenerative Diseases - metabolism Nitric Oxide - chemistry Nitric Oxide - physiology Nitrosation Protein Folding |
| Title | Nitrosative Stress in the ER: A New Role for S-Nitrosylation in Neurodegenerative Diseases |
| URI | http://dx.doi.org/10.1021/cb600244c https://www.ncbi.nlm.nih.gov/pubmed/17163772 https://search.proquest.com/docview/68246544 |
| Volume | 1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3JTsMwEB0VOMCFfSmrBVwNseMs5lYVKoQEBwoS4hI5XhACpYimB_h6Jk7DIrZLTrY1mrH9ZjIzzwD7gUEQT1JBIxkZKgx-VMwF1TZMgtQoqVnVnHx-EZ9ei7Ob6KYFe79k8Dk71HmVOhJCT8AUx_lV3Van22-u24pBXXpS1EjQFMG-oQ_6PLWCHj38Cj2_-JMeV3pzcNx059TlJA8HozI_0K_fyRr_EnkeZsd-JenUG2EBWrZYhOlu85zbEtxe3Jcoluf5Jn3fIULuC4L-Hzm5PCIdgtcduRw8WoJuLOnTevhLXSpXjfQ0HsbeeZ5qv8pxndwZLsN17-Sqe0rHDytQFbKwpM7lIrQisGmklVI5Z3loDfpuLFE2SLh2GgMXx7k1QS4RvZRkiFsqNcKpCMPaFZgsBoVdA6KsNpFzscm1E8wZGTMtpbaBYtxIFbdhGzWfjQ_GMPM5b86ydxW1YbcxSvZUE2z8NGinMVeGaqtyGqqwg9Ewi1NeMcKJNqzWVvxYBCPBEGOH9f8k2ICZ-r9KQjnbhMnyeWS30NMo822_094ApC7MdQ |
| link.rule.ids | 315,783,787,2772,27088,27936,27937,57066,57116 |
| linkProvider | American Chemical Society |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV25TsQwELU4Cmi4j-W0EK0hdpzDdGgBLdcWLEiIJnJ8oBUoi0i2gK9n7Gy4BIImlTMajR2_NxnPM0K7gQYQT1JOIhFpwjU8ZMw4USZMglRLoahrTr7sxp0bfnYb3Y5kclwvDDhRgqXSF_E_1AXovspdBYlzNY4mowSA0tGgdq_ZdZ2QuvDaqBEnKWB-oyL0-VWHQKr8ikC_0EoPLyez9T1F3jF_quRhb1jle-r1m2bj_zyfQzMjlokP62Uxj8ZMsYCm2s3lbovortuvwDuv-o17vl8E9wsMbBAfXx3gQwybH74aPBoMpBb3SD38pT4450Z6UQ9t7r1qtbdyVJd6yiV0c3J83e6Q0TULRIY0rIi1OQ8ND0waKSllzmgeGg1MjibSBAlTVkEaYxkzOsgFYJkUFFBMpppbGUGSu4wmikFhVhGWRunI2ljnynJqtYipEkKZQFKmhYxbaAsilI0-kzLzFXBGs_cQtdBOMzfZUy238dOg7WbWMgibq3DIwgyGZRanzOnD8RZaqSfzwwjkhSFkEmt_ebCNpjrXlxfZxWn3fB1N139cEsLoBpqonodmEzhIlW_5xfcGC-bU2g |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT9wwEB61VKJcaKGUbh9gIa6G2HEe7m21sOLRLogtEuISOX5UCJRFTfZAf33HTkIpKmovOU2s0Yztb8bj-QywHRkE8SwXNJGJocLgR6VcUG3jLMqNkpr55uSvk_TgXBxdJBddouh7YVCJGkeqQxHfr-pb4zqGAbarS19FEkI_hxdJxkJZdjia9juvJ1OXgR81ETRH3O-ZhB7-6lFI13-i0BOhZYCY8Ss4uVcu3Cy53pk35Y7--Yi38f-1fw3LXbRJhu30WIFntlqFl6P-kbc3cDm5alDDwP5NpqFvhFxVBKNCsn_2mQwJboLkbHZjCQa3ZEpb8bv2Ap2XDOQexn4P7NVhlL225FOvwfl4_9vogHbPLVAVs7ihzpUitiKyeaKVUiVnZWwNRnQsUzbKuHYa0xnHuTVRKRHTlGSIZio3wil0R_wWFqpZZd8BUVabxLnUlNoJ5oxMmZZS20gxbqRKB7CBViq65VIXoRLOWXFvogFs9f4pblvajb8JbfaeK9BsvtKhKjub10Wac88TJwaw3jr09yCYH8aYUbz_lwabsHi6Ny6-HE6OP8BSe_CSUc4-wkLzY24_YSjSlBth_v0CBdbXVA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nitrosative+Stress+in+the+ER%3A+A+New+Role+for+S+-Nitrosylation+in+Neurodegenerative+Diseases&rft.jtitle=ACS+chemical+biology&rft.au=Forrester%2C+Michael+T.&rft.au=Benhar%2C+Moran&rft.au=Stamler%2C+Jonathan+S.&rft.date=2006-07-21&rft.issn=1554-8929&rft.eissn=1554-8937&rft.volume=1&rft.issue=6&rft.spage=355&rft.epage=358&rft_id=info:doi/10.1021%2Fcb600244c&rft.externalDBID=n%2Fa&rft.externalDocID=10_1021_cb600244c |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1554-8929&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1554-8929&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1554-8929&client=summon |