Direct C-Arylation of β-Enamino Esters and Ketones with Arynes

An efficient, mild, and general method for the C-arylation of β-enamino esters and ketones with arynes has been developed. This methodology provides a facile and direct access to a variety of substituted aromatic β-enamino compounds in moderate to excellent yield.

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Bibliographic Details
Published inOrganic letters Vol. 9; no. 6; pp. 1029 - 1032
Main Authors Ramtohul, Yeeman K, Chartrand, Anik
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.03.2007
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Combinatorial Chemistry Techniques
Esters - chemistry
Hydrocarbons, Aromatic - chemistry
Ketones - chemistry
Molecular Structure
Physical Sciences
Science & Technology
Trimethylsilyl Compounds - chemistry
FACILE N-ARYLATION
INSERTION
ENANTIOSELECTIVE SYNTHESIS
AMINES
ACCESS
ENE REACTION
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Summary:An efficient, mild, and general method for the C-arylation of β-enamino esters and ketones with arynes has been developed. This methodology provides a facile and direct access to a variety of substituted aromatic β-enamino compounds in moderate to excellent yield.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol063057k