A Multiscale TiO2 Nanorod Array for Ultrasensitive Capture of Circulating Tumor Cells

In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a “multi-scale interacting platform” for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying th...

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Published inACS applied materials & interfaces Vol. 8; no. 20; pp. 12638 - 12643
Main Authors Sun, Na, Li, Xinpan, Wang, Zhili, Zhang, Ruihua, Wang, Jine, Wang, Kewei, Pei, Renjun
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 25.05.2016
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Abstract In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a “multi-scale interacting platform” for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying the capture performance of the BSA-aptamer TiO2 nanorod substrates and other nanostructured substrates, we can conclude that the multisacle TiO2 nanorod substrates could indeed effectively enhance the capture yields of target cancer cells. The capture yield of artificial blood samples on the BSA-aptamer TiO2 nanorod substrates is up to 85%–95%, revealing the potential application of the TiO2 nanorods on efficient and sensitive capture of rare circulating tumor cells.
AbstractList In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a "multi-scale interacting platform" for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying the capture performance of the BSA-aptamer TiO2 nanorod substrates and other nanostructured substrates, we can conclude that the multisacle TiO2 nanorod substrates could indeed effectively enhance the capture yields of target cancer cells. The capture yield of artificial blood samples on the BSA-aptamer TiO2 nanorod substrates is up to 85%-95%, revealing the potential application of the TiO2 nanorods on efficient and sensitive capture of rare circulating tumor cells.
Author Li, Xinpan
Wang, Kewei
Zhang, Ruihua
Sun, Na
Wang, Zhili
Pei, Renjun
Wang, Jine
AuthorAffiliation State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, School of Pharmacy
University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xi’an Jiaotong University
Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics
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  email: rjpei2011@sinano.ac.cn
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27176724$$D View this record in MEDLINE/PubMed
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TiO2 nanorod array
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Snippet In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a “multi-scale interacting platform” for cell capture, which exhibits excellent...
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Title A Multiscale TiO2 Nanorod Array for Ultrasensitive Capture of Circulating Tumor Cells
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