A Multiscale TiO2 Nanorod Array for Ultrasensitive Capture of Circulating Tumor Cells
In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a “multi-scale interacting platform” for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying th...
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Published in | ACS applied materials & interfaces Vol. 8; no. 20; pp. 12638 - 12643 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
25.05.2016
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Subjects | |
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Abstract | In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a “multi-scale interacting platform” for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying the capture performance of the BSA-aptamer TiO2 nanorod substrates and other nanostructured substrates, we can conclude that the multisacle TiO2 nanorod substrates could indeed effectively enhance the capture yields of target cancer cells. The capture yield of artificial blood samples on the BSA-aptamer TiO2 nanorod substrates is up to 85%–95%, revealing the potential application of the TiO2 nanorods on efficient and sensitive capture of rare circulating tumor cells. |
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AbstractList | In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a "multi-scale interacting platform" for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying the capture performance of the BSA-aptamer TiO2 nanorod substrates and other nanostructured substrates, we can conclude that the multisacle TiO2 nanorod substrates could indeed effectively enhance the capture yields of target cancer cells. The capture yield of artificial blood samples on the BSA-aptamer TiO2 nanorod substrates is up to 85%-95%, revealing the potential application of the TiO2 nanorods on efficient and sensitive capture of rare circulating tumor cells. |
Author | Li, Xinpan Wang, Kewei Zhang, Ruihua Sun, Na Wang, Zhili Pei, Renjun Wang, Jine |
AuthorAffiliation | State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, School of Pharmacy University of Chinese Academy of Sciences, Chinese Academy of Sciences Xi’an Jiaotong University Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics |
AuthorAffiliation_xml | – name: Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics – name: State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, School of Pharmacy – name: University of Chinese Academy of Sciences, Chinese Academy of Sciences – name: Xi’an Jiaotong University |
Author_xml | – sequence: 1 givenname: Na surname: Sun fullname: Sun, Na – sequence: 2 givenname: Xinpan surname: Li fullname: Li, Xinpan – sequence: 3 givenname: Zhili surname: Wang fullname: Wang, Zhili – sequence: 4 givenname: Ruihua surname: Zhang fullname: Zhang, Ruihua – sequence: 5 givenname: Jine surname: Wang fullname: Wang, Jine – sequence: 6 givenname: Kewei surname: Wang fullname: Wang, Kewei – sequence: 7 givenname: Renjun surname: Pei fullname: Pei, Renjun email: rjpei2011@sinano.ac.cn |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27176724$$D View this record in MEDLINE/PubMed |
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Title | A Multiscale TiO2 Nanorod Array for Ultrasensitive Capture of Circulating Tumor Cells |
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