2‘-O-[2-(Amino)-2-oxoethyl] Oligonucleotides

• Published in: Organic letters Vol. 5; no. 4; pp. 403 - 406
• Main Authors: Prakash, Thazha P, Kawasaki, Andrew M, Lesnik, Elena A, Owens, Stephen R, Manoharan, Muthiah
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.02.2003; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Drug Stability; Oligonucleotides, Antisense - chemical synthesis; Oligonucleotides, Antisense - chemistry; Oligonucleotides, Antisense - metabolism; Phosphodiesterase I; Phosphoric Diester Hydrolases - metabolism; Physical Sciences; RNA, Complementary - metabolism; Science & Technology; Structure-Activity Relationship; RIBONUCLEOTIDES; HYBRIDIZATION; ANTISENSE

Oligonucleotides with novel modifications, 2‘-O-[2-(amino)-2-oxoethyl] (2‘-O-NAc), 2‘-O-[2-(methylamino)-2-oxoethyl] (2‘-O-NMAc), 2‘-O-[2-(dimethylamino)-2-oxoethyl] (2‘-O-DMAc), and 2‘-O-[2-[[2-(dimethylamino)ethyl]amino]-2-oxoethyl] (2‘-O-DMAEAc), have been synthesized. These modified oligonucleot...